JAK1
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Official Full Name
Janus kinase 1
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Overview
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a -
Synonyms
JAK1; Janus kinase 1; JAK1B; tyrosine-protein kinase JAK1; JAK1A; JTK3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- Human cells
- Insect Cell
- Insect cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Yeast
- C
- His
- DYKDDDDK
- Flag
- GST
- His (Fc)
- Avi
- His|MBP
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- JAK1 Related Articles
- JAK1 Related Gene Family
- JAK1 Related Research Area
- JAK1 Related Signal Pathway
JAK1 involved in several pathways and played different roles in them. We selected most pathways JAK1 participated on our site, such as ARMS-mediated activation, Antiviral mechanism by IFN-stimulated genes, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | FRS3;KBTBD7;PAQR3B;PAQR3A;DUSP7;DUSP1;DUSP2;AKAP9;NETO2 |
| Antiviral mechanism by IFN-stimulated genes | NUP35;ARIH1L;DPF1;IFIT12;EIF4A2;NUPL2;KPNA3;EIF4G2A;EIF4E |
| Axon guidance | EFNB1;MYL12B;L1CAM;Plxna2;WDR83;FGF10B;DLG3;DNM1;LAMTOR2 |
| Cytokine Signaling in Immune system | PAQR3A;PHB;DPF1;NOD1;CRK;TRIM46;TRIM26;HBEGF;NUP50 |
| DAP12 interactions | CNKSR1;DUSP10;SIRPB1;PEA15A;JAK1;SIGLEC15;WDR83;KBTBD7;HBEGF |
| DAP12 signaling | FGF10B;CSF2RA;LAMTOR2;SPNA1;NEFLB;HBEGF;IL17RD;KLB;AGO1 |
| Developmental Biology | SEMA3A;FRS2A;SCN3A;CHL1;RGMA;MYOD1;ST8SIA2;CRMP1;KCNQ2 |
| Downstream signal transduction | AGO2;FRS2B;PEA15A;SPNA1;PAQR3B;SPTBN2;RASGEF1A;MARK3;WDR83 |
JAK1 has several biochemical functions, for example, ATP binding, CCR5 chemokine receptor binding, growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK1 itself. We selected most functions JAK1 had, and list some proteins which have the same functions with JAK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | OASL1;ITPKC;KIF16B;KIF20B;YME1L1;SPO11;PAPOLA;MAPKAPK2A;PHKG2 |
| CCR5 chemokine receptor binding | CCL4;STAT3;CNIH4;CCL5;JAK1;CCL3 |
| growth hormone receptor binding | Gh;JAK2;TYK2;JAK1;SOCS2;GH1 |
| non-membrane spanning protein tyrosine kinase activity | JAK2B;TNK2B;TYK2;ABL1;FER;FGR;BMX;ZNF143B;PTK6B |
| protein binding | CCL3;PPP2R5A;MEIS1B;SEPT3;ALKBH6;NAV1;UQCC1;DSG1A;SULT1A2 |
| protein phosphatase binding | ANAPC7;FGF19;ANAPC5;PPP6R1;TRP53;VRK3;STAT3;VCAN;KAT2A |
| protein tyrosine kinase activity | CLK2;ERBB2;RET;YES1;BLK;TEK;FGFR3;PDGFRB;AXL |
| ubiquitin protein ligase binding | PRKAR1A;TCP1;PA2G4;MAGEC2;GABARAP;JAK1;DERL1;CUL3;CDC34B |
JAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK1.
IFNAR2; STAM2; ERBB2; Dlg4; P; v_rindsa; HSP90AB1; IL6R; PRKCA; BRCA1; P/V; V
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Customer Reviews (3)
Write a reviewTop-notch purity, impressive results.
Excellent stability, very useful.
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