JAK1 Protein


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Official Full Name Janus kinase 1
Background Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a
Synonyms JAK1; Janus kinase 1; JAK1B; tyrosine-protein kinase JAK1; JAK1A; JTK3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human cells
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • Flag
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human JAK1-159H Recombinant Human JAK1 protein, His/MBP-tagged E.coli His/MBP
    Human JAK1-160H Recombinant Human JAK1 protein, His/MBP-tagged E.coli His/MBP
    Human JAK1-18H Recombinant Human JAK1 protein, GST-tagged Insect Cell GST
    Human JAK1-249H Recombinant Human JAK1 Mammalian Cell His
    Human JAK1-28H Recombinant Human JAK1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human JAK1-56H Recombinant Human JAK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human JAK1-670H Recombinant Human JAK1, GST-tagged Sf9 Insect Cell GST
    Human JAK1-674H Recombinant Human Janus Kinase 1, GST-tagged Insect Cell GST
    Mouse Jak1-7876M Recombinant Mouse Jak1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque JAK1-2326R Recombinant Rhesus monkey JAK1 Protein, His-tagged Mammalian Cell His
    Chicken JAK1-6433C Recombinant Chicken JAK1 Mammalian Cell His
    Zebrafish JAK1-8699Z Recombinant Zebrafish JAK1 Mammalian Cell His
    Human JAK1-5107HCL Recombinant Human JAK1 293 Cell Lysate HEK293 N/A
    Human JAK1-151H Recombinant Human JAK1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human JAK1-2667H Recombinant Human JAK1 protein, His-tagged E.coli His
    Human JAK1-3126H Recombinant Human JAK1 protein, His-tagged E.coli His
    Mouse Jak1-3127M Recombinant Mouse Jak1 protein, His-tagged E.coli His
    Human JAK1-1941H Recombinant Human JAK1 Protein (850-1154 aa), His-tagged Yeast His
    Human JAK1-938H Recombinant Human JAK1 protein, His-tagged Insect cells His
    Mouse Jak1-3626M Recombinant Mouse Jak1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    JAK1 involved in several pathways and played different roles in them. We selected most pathways JAK1 participated on our site, such as ARMS-mediated activation, Antiviral mechanism by IFN-stimulated genes, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation HBEGF; RASGRP4; PEA15A; MARK3; DUSP2; IL17RD; NRG4; FGFR1B; FGF18B; NTF7
    Antiviral mechanism by IFN-stimulated genes MX2; NUP35; ARIH1L; KPNA3; IFIT11; JAK1; HERC5; EIF4EB; NUPL2; IFIT14
    Axon guidance SEMA5A; EZRA; NTNG1; SPTBN2; RGMA; UNC5C; EFNB3B; COL4A3; CSNK2A2; PHB
    Cytokine Signaling in Immune system FGF8B; TRIM3; USP18; EIF4EB; EDA; FRS3; TRIM68; IFITM2; TRIM62; RASGRP1
    DAP12 interactions FGF8B; PAQR3A; FGFR1B; AGO3; FRS2; HBEGF; SPTBN1; PEA15; SPRED2; NEFLB
    DAP12 signaling AGO2; FRS2; SPNA1; PEA15; GRAP2A; DUSP1; AGO3; JAK3; PEBP1; DUSP10
    Developmental Biology PEBP1; COL6A3; AP2A1; MEF2B; RND1L; CDK5R1B; ARPC2; CNTN1; COL4A5; SPTBN2
    Downstream signal transduction AGO3; TRAT1; DUSP2; SPRED1; KBTBD7; PTPRA; AGO1; FGF20A; DAB2IPB; FGF10B

    JAK1 has several biochemical functions, for example, ATP binding, CCR5 chemokine receptor binding, growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK1 itself. We selected most functions JAK1 had, and list some proteins which have the same functions with JAK1. You can find most of the proteins on our site.

    Function Related Protein
    CCR5 chemokine receptor binding CCL5; JAK1; CCL4; STAT3; CNIH4; CCL3
    growth hormone receptor binding SOCS2; JAK2; GH1; TYK2; Gh; JAK1
    non-membrane spanning protein tyrosine kinase activity CSK; YES1; PTK2B; FYN; ABL2; PTK2AA; JAK2; JAK2B; TXK; MELK
    protein binding TBX24; KRTAP4-2; CCNF; BRD3; ZNF276; CTSL2; RPN1; PPP2R1A; FAM109A; C17orf59
    protein phosphatase binding STAT3; MVP; DLG4; EGFR; CDH5; ROS1; RPA3; DLG3; ITPR1; PPARG
    protein tyrosine kinase activity BCR; FGFR3; MAP2K2; TEK; PTK2AB; HCK; TNK2; SYK; IGF1RB; FGFR1A
    ubiquitin protein ligase binding UBE2V1; FHIT; MC1R; SMAD7; LC3; MAGEA2B; RELA; PRDX6; ARRB2; TRIM37

    JAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK1.

    IFNAR2; STAM2; ERBB2; Dlg4; P; v_rindsa; HSP90AB1; IL6R; PRKCA; BRCA1; P/V; V

    Cianciulli, A; Dragone, T; et al. IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. INTERNATIONAL IMMUNOPHARMACOLOGY 24:369-376(2015).
    Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).

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