JAK1

  • Official Full Name

    Janus kinase 1

  • Overview

    Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a
  • Synonyms

    JAK1; Janus kinase 1; JAK1B; tyrosine-protein kinase JAK1; JAK1A; JTK3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Insect Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Yeast
  • C
  • His
  • DYKDDDDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAK1-670H Active Recombinant Human JAK1, GST-tagged Sf9 Insect Cell GST
Human JAK1-18H Active Recombinant Human JAK1 protein, GST-tagged Insect Cell GST
Human JAK1-115H Active Recombinant Human JAK1(866-end) Protein, N-GST-tagged Sf21 GST 866-end
Human JAK1-56H Recombinant Human JAK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human JAK1-28H Recombinant Human JAK1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human JAK1-249H Recombinant Human JAK1 Mammalian Cell His
Human JAK1-674H Recombinant Human Janus Kinase 1, GST-tagged Insect Cell GST
Human JAK1-159H Recombinant Human JAK1 protein, His/MBP-tagged E.coli His/MBP 450-618 aa
Human JAK1-160H Recombinant Human JAK1 protein, His/MBP-tagged E.coli His/MBP 1-189 aa
Human JAK1-5107HCL Recombinant Human JAK1 293 Cell Lysate HEK293 N/A
Human JAK1-151H Recombinant Human JAK1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human JAK1-938H Recombinant Human JAK1 protein, His-tagged Insect cells His Ala 561 - Asn 852
Human JAK1-1941H Recombinant Human JAK1 Protein (850-1154 aa), His-tagged Yeast His 850-1154 aa
Human JAK1-3126H Recombinant Human JAK1 protein, His-tagged E.coli His 850-1154aa
Human JAK1-151HFL Recombinant Full Length Human JAK1 Protein, C-Flag-tagged Mammalian cells Flag
Human JAK1-2667H Recombinant Human JAK1 protein, His-tagged E.coli His 1080-1151 aa
Human JAK1-0263H Recombinant Human JAK1 Protein (Ile841-Lys1154), C-His-tagged Baculovirus-Insect cells C-His Ile841-Lys1154
Human JAK1-1227H Recombinant Human JAK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human JAK1-3130H Recombinant Human JAK1 Protein (Pro32-Phe286), N-His tagged E.coli N-His Pro32-Phe286
Human JAK136418H Recombinant Human JAK1 (849-1154) Protein
Human JAK13406H Recombinant Human JAK1 (854-1154) Protein
Human JAK136170H Recombinant Human JAK1 (865-1154) Protein
Human JAK1-1227H-B Recombinant Human JAK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Jak1-7876M Recombinant Mouse Jak1 protein, His & T7-tagged E.coli His/T7 Gln833~Leu1074 (Accession # P52332)
Mouse Jak1-3626M Recombinant Mouse Jak1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Jak1-3127M Recombinant Mouse Jak1 protein, His-tagged E.coli His 848-1152aa
Rhesus Macaque JAK1-2326R Recombinant Rhesus monkey JAK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque JAK1-2147R Recombinant Rhesus Macaque JAK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque JAK1-2147R-B Recombinant Rhesus Macaque JAK1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish JAK1-8699Z Recombinant Zebrafish JAK1 Mammalian Cell His
Chicken JAK1-6433C Recombinant Chicken JAK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • JAK1 Related Signal Pathway

JAK1 involved in several pathways and played different roles in them. We selected most pathways JAK1 participated on our site, such as ARMS-mediated activation, Antiviral mechanism by IFN-stimulated genes, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationSPTBN1;NRG3;RASGRP4;KIDINS220B;SPNA1;CSF2;LAMTOR2;PSMD14;PSMD9
Antiviral mechanism by IFN-stimulated genesEIF4E3;EIF4G2;MX2;DPF1;NUP35;KPNA3;IFIT11;IFIT14;EIF4EB
Axon guidanceST8SIA2;SDCBP;AP2B1;DOCK1;SEMA4D;RHOAE;CLTB;RASGRP4;AGRN
Cytokine Signaling in Immune systemPEA15A;DUSP1;NUP35;SOCS3A;DUSP7;SPNA2;NUP50;IFI35;DUSP5
DAP12 interactionsGRAP2A;PEBP1;AGO3;DUSP4;CD300E;KIR3DS1;MARK3;AGO2;RASGEF1A
DAP12 signalingPEA15A;DUSP10;THEM4;FRS2A;AGO3;JAK3;WDR83;DAB2IPB;DUSP1
Developmental BiologySREBF2;EZRA;TRPC5;FGF18B;FGFR1B;RHOAE;NR2F2;ITGB1B.1;ARPC1B
Downstream signal transductionSPTB;JAK1;FGFR1B;FRS3;KBTBD7;SPTA1;DUSP2;PEA15;AGO2

JAK1 has several biochemical functions, for example, ATP binding, CCR5 chemokine receptor binding, growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK1 itself. We selected most functions JAK1 had, and list some proteins which have the same functions with JAK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTLK2;HSPE1;DHX9;KIF22;MADD;MSH5;MLH1;AK7;NLRC4
CCR5 chemokine receptor bindingCNIH4;STAT3;CCL3;CCL4;CCL5;JAK1
growth hormone receptor bindingJAK2;TYK2;GH1;SOCS2;JAK1;Gh
non-membrane spanning protein tyrosine kinase activitySTYK1;PTK2AA;SYK;JAK2B;ZAP70;DYRK1A;FGR;PTK6;EIF2AK2
protein bindingPRPF8;ZRANB1;PIH1D2;SNTB1;RNH1;RAB39B;SYNDIG1;RHOH;PTBP1
protein phosphatase bindingROS1;DRD1;RPA3;TRP53;CSF1R;MAP3K5;ITGA1;AP3B1;VCP
protein tyrosine kinase activityKDRL;LYN;MAP2K1;DSTYK;FGR;CLK3;TNK2B;ROS1;FGFR3
ubiquitin protein ligase bindingTRIB2;CASP8;UBE2B;CDKN1A;IKBKG;DLG3;UCHL1;WFS1;PPARGC1A

JAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK1.

IFNAR2; STAM2; ERBB2; Dlg4; P; v_rindsa; HSP90AB1; IL6R; PRKCA; BRCA1; P/V; V

Gene Family

TGF Cytokines

Research Area

Related articles

Cianciulli, A; Dragone, T; et al. IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. INTERNATIONAL IMMUNOPHARMACOLOGY 24:369-376(2015).
Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).
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Reviews
03/13/2022

    Top-notch purity, impressive results.

    09/30/2021

      Excellent stability, very useful.

      11/17/2020

        Fast and reliable delivery.

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