KAT2A

  • Official Full Name

    K(lysine) acetyltransferase 2A
  • Overview

    KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also;functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA;(MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)).
  • Synonyms

    KAT2A;K(lysine) acetyltransferase 2A;GCN5 general control of amino acid synthesis 5 like 2 (yeast) , GCN5L2;histone acetyltransferase KAT2A;GCN5;PCAF b;STAF97;hsGCN5;lysine acetyltransferase 2A;histone acetyltransferase GCN5;general control of a

Recombinant Proteins

  • Human
  • Sf9 Cells
  • Sf21 Cells
  • Human
  • E.coli
  • Insect Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KAT2A-1392H Active Recombinant Human KAT2A, GST-tagged Sf9 Cells Human GST 323 aa-end
KAT2A-274H Active Recombinant Human KAT2A, His-tagged Sf21 Cells Human His
KAT2A-1017H Recombinant Human KAT2A, His-tagged Human Human His
KAT2A-120H Recombinant Human KAT2A Protein, GST-tagged E.coli Human GST 726-837
KAT2A-18H Recombinant Human KAT2A Protein, GST-tagged E.coli Human GST 721-837 a.a.
KAT2A-2129H Recombinant Human K(lysine) Acetyltransferase 2A, His-tagged Insect Cells Human His
KAT2A-2132H Recombinant Human KAT2A protein, GST-tagged Wheat Germ Human GST 1-837 a.a.
KAT2A-29886TH Recombinant Human KAT2A, His-tagged E.coli Human His 427 amino acids
KAT2A-005H Recombinant Human KAT2A Protein, His-tagged Insect Cells Human His 2-837
KAT2A-058H Recombinant Human KAT2A Protein, His-tagged Insect Cells Human His 2-837
KAT2A-080H Recombinant Human lysine acetyltransferase 2A Protein, His tagged E.coli Human His 497-662aa
KAT2A-2352H Recombinant Human KAT2A Protein, His-tagged E.coli Human His Ala648-Lys837
KAT2A-290HCL Recombinant Human KAT2A HEK293T cell lysate HEK293 Human DDK&Myc
KAT2A-5764H Recombinant Human KAT2A protein, His-tagged E.coli Human His
KAT2A-5765H Recombinant Human KAT2A protein, GST-tagged E.coli Human GST
KAT2A-679HF Recombinant Full Length Human KAT2A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 837 amino acids

    Involved Pathway

    KAT2A involved in several pathways and played different roles in them. We selected most pathways KAT2A participated on our site, such as Notch signaling pathway,Thyroid hormone signaling pathway,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway NOTCH1,SNW1,CTBP2,APH1B,JAG1A,CIR1,MIB1,MFAP5,APH1C,NOTCH1A
    Viral carcinogenesis CCND1,MAD1L1,GTF2H1,CCNA1,HIST1H2BE,MAPKAPK2,HLA-G,HIST1H2BQ,TRAF2,SRF
    HTLV-I infection PIK3CB,PIK3CA,PDGFB,WNT8A,ANAPC7,PIK3CD,SLC25A31,POLD1,TSPO,HRAS
    Thyroid hormone signaling pathway SIN3A,SRC,ATP1B3,KAT2B,ATP1B4,PLCG2,PLCB2,MED12,RCAN2,MAP2K2

    Protein Function

    KAT2A has several biochemical functions, for example, H3 histone acetyltransferase activity,chromatin binding,histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT2A itself. We selected most functions KAT2A had, and list some proteins which have the same functions with KAT2A. You can find most of the proteins on our site.

    Function Related Protein
    histone deacetylase binding HDAC9,SP2,USF1,TOP2A,RUNX2,HEY2,D7ERTD443E,BRMS1LA,NKX3,TRAF6
    transcription factor binding ZBTB49,HTT,BCL10,MLXIPL,PPARGC1A,DOT1L,SMARCD3,JUND,TRIB1,PRICKLE1
    chromatin binding PRKAA1,TWIST2,HMGB3A,BEND6,TP73,SUV39H1,PHF21A,YAP1,HMGN5,BARX2
    transcription coactivator activity NFYC,POU2AF1,GTF2A2,YY1,RFXAP,MED27,WWTR1,CCAR1,WNT3A,NCOA3
    histone acetyltransferase activity CREBBP,KAT5,TAF1L,KAT7A,TAF1,EP300,KAT7B,MED24,NCOA1,KAT8
    protein binding DNAJB4,ISCA2,DYNC1H1,RNF5,APPB,TIRAP,SHOX,PLP2,POC1B,DNAI1
    contributes_to histone acetyltransferase activity TAF6L,KAT5,EPC1,SAP130,TADA3,SUPT3H,TAF5L,SUPT7L,TEX30,ELP4
    H3 histone acetyltransferase activity BRCA2,ELP3
    protein phosphatase binding JUPA,CDH5,MAPK14,FLT4,DRD1A,STAT3,DRD1,SHOC2,PPP6R1,ROS1

    Interacting Protein

    KAT2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT2A here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT2A.

    TRRAP;WDHD1;ATXN7;BRCA1

    Resources

    References

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