KAT2A
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Official Full Name
K(lysine) acetyltransferase 2A -
Overview
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also;functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA;(MIM 164014) in a HAT-independent manner (Mao et al., 2009 (PubMed 19339690)). -
Synonyms
KAT2A;K(lysine) acetyltransferase 2A;GCN5 general control of amino acid synthesis 5 like 2 (yeast) , GCN5L2;histone acetyltransferase KAT2A;GCN5;PCAF b;STAF97;hsGCN5;lysine acetyltransferase 2A;histone acetyltransferase GCN5;general control of a
Recombinant Proteins
- Human
- Sf9 Cells
- Sf21 Cells
- Human
- E.coli
- Insect Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- DDK
- Myc
Involved Pathway
KAT2A involved in several pathways and played different roles in them. We selected most pathways KAT2A participated on our site, such as Notch signaling pathway,Thyroid hormone signaling pathway,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | MED27,PRKCA,PLCD1,MED24,ITGB3,GATA4,MED12L,NCOA3,TRP53,MED13 |
| HTLV-I infection | IKBKG,POLD2,NFKB2,VAC14,HLA-DPB1,NFATC2,TBP,TCF3,IL2RG,HLA-F |
| Notch signaling pathway | PSEN2,ADAM12,CNTN6,HDAC2,MAML2,NOTCH3,DTX1,NUMBL,DLK1,DLL4 |
| Viral carcinogenesis | RB1,IKBKG,RHOA,DDX3X,TBPL1,HNRNPK,HIST1H4B,SP100,PRKACA,EGR3 |
Protein Function
KAT2A has several biochemical functions, for example, H3 histone acetyltransferase activity,chromatin binding,histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT2A itself. We selected most functions KAT2A had, and list some proteins which have the same functions with KAT2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | IGHMBP2,ESR1,PRICKLE1,PSMD4,CREG1,PER1,DDIT3,E2F1,UBE2I,NFIA |
| protein binding | PAPOLA,GAST,C7orf25,SYNE3,NELL1,FOSL2,TSEN2,BUD13,SDCCAG3,UNC119 |
| chromatin binding | PPARGC1A,NKAP,ANKRD17,SIX1,CALCOCO1,CHAF1A,RBMX,STAG2,BAHCC1,TOX2 |
| transcription coactivator activity | RNF4,RB1,TRIM24,NCOA3,CD3D,ZEB1,RBPMS,ESRRB,MNT,TFAP2B |
| H3 histone acetyltransferase activity | BRCA2,ELP3 |
| histone acetyltransferase activity | HAT1,TAF1,CDYL,TAF1L,CREBBP,NCOA1,CSRP2BP,GTF3C4,HTATIP,NCOA2 |
| protein phosphatase binding | PPARG,GRB2,CSK,HSF4,VCAN,PPME1,ANAPC7,ITPR1,ANAPC4,Itga10&Itgb1 |
| histone deacetylase binding | GLI3,MAPK8,GMNN,TFAP4,HDAC5,KLF4,MYOCD,KPNA2,SOD3,BRMS1 |
| contributes_to histone acetyltransferase activity | KAT5,TAF12,TEX30,TADA2B,TADA1,ING3,SUPT3H,TAF5L,SAP130,TAF6L |
Interacting Protein
KAT2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT2A here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT2A.
TRRAP;WDHD1;ATXN7;BRCA1
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