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KLKB1

  • Official Full Name

    kallikrein B, plasma (Fletcher factor) 1

  • Overview

    Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
  • Synonyms

    KLKB1; kallikrein B, plasma (Fletcher factor) 1; PPK; KLK3; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Urine
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Porcine (pig) Pancreas
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLKB1-483H Active Recombinant Human Kallikrein B, Plasma (Fletcher factor) 1, His-tagged Mammalian cells His
Human KLKB1-210H Active Native Human Kallikrein Human Urine N/A
Human KLKB1-1815H Recombinant Human KLKB1 protein, His & T7-tagged E.coli His/T7 Thr156~Thr364 (Accession # P03952)
Human KLKB1-485H Recombinant Human KLKB1 protein, His-tagged HEK293 His Gly20-Ala638
Human KLKB1-4899HCL Recombinant Human KLKB1 293 Cell Lysate HEK293 N/A
Human KLKB1-3238H-B Recombinant Human KLKB1 Protein Pre-coupled Magnetic Beads HEK293
Human KLKB1-5870HF Recombinant Full Length Human KLKB1 Protein, GST-tagged In Vitro Cell Free System GST 638 amino acids
Human KLKB1-4925H Recombinant Human KLKB1 Protein, GST-tagged Wheat Germ GST
Human KLKB1-3238H Recombinant Human KLKB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KLKB1-4354H Recombinant Human KLKB1 Protein (Ala65-Phe348), N-His tagged E.coli N-His Ala65-Phe348
Human KLKB1-4355H Recombinant Human KLKB1 Protein (Met1-Ala638), C-His tagged Mammalian cells C-His Met1-Ala638
Human KLKB1-2202H Recombinant Human KLKB1 Protein (20-390 aa), His-tagged Yeast His 20-390 aa
Human KLKB1-27924TH Native Human KLKB1 N/A
Human KLKB1-5999H Recombinant Human KLKB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human KLKB1-4352H Recombinant Human KLKB1 Protein (Gly20-Ala638), C-His tagged Mammalian cells C-His Gly20-Ala638
Mouse Klkb1-606M Active Recombinant Mouse Klkb1 Protein, His-tagged Mammalian cells His Gly20-Ala638
Mouse KLKB1-8757M Recombinant Mouse KLKB1 Protein Mammalian Cell His
Mouse Klkb1-117M Recombinant Mouse Klkb1 Protein, His-tagged E.coli His His39~Pro261
Mouse Klkb1-4883M Recombinant Mouse Klkb1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Klkb1-4883M-B Recombinant Mouse Klkb1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Klkb1-1277M Recombinant Mouse Klkb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat KLKB1-1267R Recombinant Rat KLKB1 Protein, His-tagged Yeast His
Rat Klkb1-2757R Recombinant Rat Klkb1 Protein, His-tagged E.coli N-His Asn68-Pro255
Rat KLKB1-605R Recombinant Rat KLKB1 Protein (391-638 aa), His-tagged E.coli His 391-638 aa
Pig KLKB1-211S Active Native Porcine Kallikrein Porcine (pig) Pancreas N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KLKB1 Related Research Area

KLKB1 involved in several pathways and played different roles in them. We selected most pathways KLKB1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesCFD;F2;F13B;F11;CD59A;C4BPA;SERPINA1A;C1QC;F12

KLKB1 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLKB1 itself. We selected most functions KLKB1 had, and list some proteins which have the same functions with KLKB1. You can find most of the proteins on our site.

Function Related Protein
protein bindingTOP1;MAB21L2;NLK;PPARGC1A;GALR2;DHX8;CDPF1;IL2RB;SHFM1
serine-type endopeptidase activityPREP;PCSK2;PRSS46;HGF;ELANE;PRSS59.1;PRSS39;MCPT9;PRSS8

KLKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLKB1.

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