LEPR

  • Official Full Name

    leptin receptor

  • Overview

    The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
  • Synonyms

    OBR; OB-R; CD295; LEP-R; LEPR; leptin receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • hFc
  • Fc
  • Fc|His
  • His(C
  • ter)
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LEPR-1249H Recombinant Human Leptin Receptor E.coli N/A
Human LEPR-669H Recombinant Human LEPR protein, His & T7-tagged E.coli His/T7 Gly310~Pro539 (Accession # P48357)
Human LEPR-29427TH Recombinant Human LEPR Wheat Germ N/A 100 amino acids
Human LEPR-799H Recombinant Human LEPR protein, Fc-tagged HEK293 human/IgG1/Fc Phe22-Asp839
Human LEPR-1662H Recombinant Human Leptin Receptor, Fc-His Mammalian cells Fc/His
Human LEPR-800H Recombinant Human LEPR protein(Met1-Asp839), His&hFc-tagged HEK293 C-His&hFc Met1-Asp839
Human LEPR-515H Recombinant Human LEPR protein, His-tagged HEK293F His Phe22~Asp839
Human LEPR-3160H Active Recombinant Human LEPR, His-tagged HEK293 His Met 1-Asp 839
Human LEPR-801H Recombinant Human LEPR Wheat Germ N/A
Human LEPR-505H Recombinant Human LEPR Mammalian Cell His
Human LEPR-2175HCL Recombinant Human LEPR cell lysate Human Cell N/A
Human LEPR-226H Recombinant Human LEPR Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Thr20-Asp839
Human LEPR-283HF Recombinant Full Length Human LEPR Protein In Vitro Cell Free System
Human LEPR-0357H Recombinant Human LEPR protein, Fc-tagged HEK293 Fc Phe22-Asp839
Human LEPR-059H Recombinant Human LEPR Protein E.coli 1165
Human LEPR-229H Recombinant Human LEPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LEPR-4434H Recombinant Human LEPR Protein (Thr20-Asp839), C-His tagged Mammalian cells C-His Thr20-Asp839
Human LEPR-1236H Recombinant Human LEPR Protein (Gly310-Leu538), N-His tagged E.coli N-His Gly310-Leu538
Human LEPR-350H Recombinant Human LEPR Protein, Fc-tagged HEK293 Fc 1165
Human LEPR-229H-B Recombinant Human LEPR Protein Pre-coupled Magnetic Beads HEK293
Mouse Lepr-670M Recombinant Mouse Lepr protein, His & T7-tagged E.coli His/T7 Leu22~Lys203 (Accession# P48356)
Mouse Lepr-1766M Recombinant Mouse Leptin Receptor Mammalian cells N/A
Mouse Lepr-01M Recombinant Mouse Lepr, His-tagged Human Cell His
Mouse LEPR-9049M Recombinant Mouse LEPR Protein Mammalian Cell His
Mouse Lepr-10589M Recombinant Mouse Lepr Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lepr-02M Recombinant Mouse Lepr(Leu22­Gly839) Protein, C-mFc-tagged HEK293 mFc
Mouse Lepr-10589M-B Recombinant Mouse Lepr Protein Pre-coupled Magnetic Beads HEK293
Mouse Lepr-03M Recombinant Mouse Lepr(Leu22-Gly839) Protein, C-Fc-tagged HEK293 Fc
Rat Lepr-671R Recombinant Rat Lepr protein, His & T7-tagged E.coli His/T7 Pro238~Pro375 (Accession# Q62959)
Rhesus monkey LEPR-1689R Recombinant Rhesus Monkey LEPR Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey LEPR-1688R Recombinant Rhesus Monkey LEPR Protein HEK293 N/A
Rhesus monkey LEPR-1690R Recombinant Rhesus Monkey LEPR Protein, hIgG4-tagged HEK293 hIgG4
Rhesus Macaque LEPR-2497R Recombinant Rhesus monkey LEPR Protein, His-tagged Mammalian Cell His
Rhesus Macaque LEPR-2318R Recombinant Rhesus Macaque LEPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LEPR-2318R-B Recombinant Rhesus Macaque LEPR Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LEPR-6284Z Recombinant Zebrafish LEPR Mammalian Cell His
Chicken LEPR-1250C Recombinant Chicken Leptin Receptor E.coli N/A
Chicken LEPR-5896C Recombinant Chicken LEPR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

LEPR involved in several pathways and played different roles in them. We selected most pathways LEPR participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL23;IL5RA;IL6;CCR6A;EDA2R;GM13304;IL2RGB;Ifna11;IL12RB2
Neuroactive ligand-receptor interactionP2RX1;NPBWR2;TSHR;CHRNA3;HTR1F;NPY5R;TAAR14G;LEP;CHRNA7
AMPK signaling pathwayMLYCD;TSC2;PFKFB3;PDPK1;RPS6KB1;STK11;FOXO1;PPP2R5E;CREB5
Jak-STAT signaling pathwayIL10RB;FHL1;PIK3R2;IL28A;IFNA16;IL12RB1;STAT1B;SOS1;IL3RA
Adipocytokine signaling pathwayIRS4;ADIPOR1;NFKBIAB;RELA;SLC2A1A;AGRP;RXRG;CHUK;PRKAB1
Non-alcoholic fatty liver disease (NAFLD)BID;SDHA;IKBKB;PIK3CA;COX6A2;NDUFA12;NDUFS3;NDUFA2;PRKAG2

LEPR has several biochemical functions, for example, cytokine receptor activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPR itself. We selected most functions LEPR had, and list some proteins which have the same functions with LEPR. You can find most of the proteins on our site.

Function Related Protein
cytokine receptor activityIL4R.1;IL1RL1;IL12B;IL17RB;F3;IL20RA;IL31RA;CRFB6;IL12RB1
identical protein bindingCLDN23;MCPH1;THG1L;LCK;ANXA4;KCNJ2;CHMP4B;CHMP4A;FUS
protein bindingRPS16;BMPR1B;NOXO1;FOXP3;LIMD1;UNKL;UTP3;SHC1;RBBP5
transmembrane signaling receptor activityFCAMR;BAI2;ICAM1;DNER;GHRHRL;SEMA4D;ENG;LGR5;FCGR2C

LEPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPR here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPR.

PTPN11; PTPRC; PTPRJ; GRB2; CSNK2B; PIN1; JAK2; JAK3

Gene Family

IL

Research Area

Related articles

Kapodistria, K; Tsilibary, EP; et al. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. MOLECULAR AND CELLULAR ENDOCRINOLOGY 400:112-128(2015).
Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).
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