MAP4K1
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Official Full Name
mitogen-activated protein kinase kinase kinase kinase 1
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Background
Hematopoietic progenitor kinase 1(HPK1) is a member of the germinal center kinases that is predominantly expressed in hematopoietic cells. HPK1 is a key component linking T or B cell receptors to SAPK/JNK and IkappaB kinase pathways in lymphocytes. Throug -
Synonyms
MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; hematopoietic progenitor kinase 1; HPK1; MEKKK 1; MEK kinase kinase 1; MAPK/ERK kinase kinase kinase 1;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Dog | MAP4K1-04D | Recombinant Dog MAP4K-1 Protein | Insect cell | N/A |
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| Human | MAP4K1-27602TH | Recombinant Human MAP4K1 | Sf9 Insect Cell | N/A |
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| Human | MAP4K1-1041H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged | Sf9 Insect Cell | GST |
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| Human | MAP4K1-79H | Recombinant Human MAP4K1 Protein, GST-tagged | Insect cells | GST |
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| Monkey | MAP4K1-03M | Recombinant Monkey MAP4K-1 Protein | Insect cell | N/A |
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| Mouse | Map4k1-9520M | Recombinant Mouse Map4k1 Protein, GST-tagged | Insect cells | GST |
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- Involved Pathway
- Protein Function
- Interacting Protein
MAP4K1 involved in several pathways and played different roles in them. We selected most pathways MAP4K1 participated on our site, such as B Cell Receptor Signaling Pathway, BCR signaling pathway, Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | CD79B;BLK;GRB2;PIK3R2;LCP2A;LYN;IFITM1;ARPC4;PPP3CB |
| BCR signaling pathway | CSNK2A1;CSK;PAG1;IBTK;DOK1;POU2F2;MAP4K1;MALT1;NETO2 |
| Insulin Signaling | RHOJ;REG1A;MAPK6;GSK3AB;EHD1;ARHGAP33;STXBP1A;STXBP3;RRAD |
| JNK signaling in the CD4+ TCR pathway | DBNL;MAP4K1 |
| MAPK signaling pathway | GRB2A;DUSP3;MAP2K2A;MAPK8IP2;MAPK13;BRAF;RAC2;AKT1;PRKCG |
| Prostate Cancer | IKBKG;MAP2K1;IGF1;PIK3R5;SPRY1;MAPK3;PDGFRA;MAP4K1;NKX3 |
| Signaling events mediated by Stem cell factor receptor (c-Kit) | SH2B3;STAP1;PTPRO;EVLA;MAP4K1 |
| Signaling of Hepatocyte Growth Factor Receptor |
MAP4K1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K1 itself. We selected most functions MAP4K1 had, and list some proteins which have the same functions with MAP4K1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | LRRK2;RUNX3;RIPK1;EPHB4B;POMK;C9orf96;MYH11A;MTHFS;TRIO |
| MAP kinase kinase kinase kinase activity | MAP4K3;ALPK2;MAP4K5;MAP4K1;MAP4K6;MAP4K2 |
| protein binding | KIF5A;RBP5;GRB10;TNNT1;SLC48A1;HAT1;BAZ1A;APPL1;CBLB |
| protein kinase activity | GSG2;PIK3CG;CSNK1G2B;CSNK1G3;BMPR1BA;ARAF;TLK1B;MAP3K11;FGFR1A |
| protein serine/threonine kinase activity | RPS6KA3A;MAP2K2A;RPS6KA2;OXSR1B;PAK2A;CDC42BPB;PAK4;CDC42BPA;Aatk |
MAP4K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K1.
GRB2; PLCG1; NCK1; CRK
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