MAP4K1

  • Official Full Name

    mitogen-activated protein kinase kinase kinase kinase 1

  • Overview

    Hematopoietic progenitor kinase 1(HPK1) is a member of the germinal center kinases that is predominantly expressed in hematopoietic cells. HPK1 is a key component linking T or B cell receptors to SAPK/JNK and IkappaB kinase pathways in lymphocytes. Throug
  • Synonyms

    MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; hematopoietic progenitor kinase 1; HPK1; MEKKK 1; MEK kinase kinase 1; MAPK/ERK kinase kinase kinase 1;

  • Recombinant Proteins
  • Dog
  • Human
  • Human
  • Monkey
  • Mouse
  • Rat
  • Insect Cell
  • Insect cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • His
  • GST
  • GST,His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP4K1-103H Active Recombinant Human MAP4K1(1-346) Protein, C-His,N-GST-tagged Sf21 GST,His 1-346 aa
Human MAP4K1-27602TH Recombinant Human MAP4K1 Sf9 Insect Cell N/A 346 amino acids
Human MAP4K1-1041H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged Sf9 Insect Cell GST
Human MAP4K1-79H Recombinant Human MAP4K1 Protein, GST-tagged Insect cells GST
Mouse Map4k1-9520M Active Recombinant Mouse Map4k1 Protein, GST-tagged Insect cells GST
Rat MAP4K1-05R Recombinant Rat MAP4K1 Protein, C-His tagged Insect Cell C-His
Monkey MAP4K1-03M Recombinant Monkey MAP4K1 Protein, C-His tagged Insect Cell C-His
Dog MAP4K1-04D Recombinant Dog MAP4K1 Protein, GST tagged Insect Cell GST
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MAP4K1 involved in several pathways and played different roles in them. We selected most pathways MAP4K1 participated on our site, such as B Cell Receptor Signaling Pathway, BCR signaling pathway, Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B Cell Receptor Signaling PathwayCTNNB2;ITPR2;CDK2;KRAS;CR2;PDPK1A;DOK3;ARPC1B;MAPK4
BCR signaling pathwayIBTK;PAG1;CSNK2A1;MAP4K1;MALT1;POU2F2;NETO2;DOK1;CSK
Insulin SignalingMAPK6;MAP3K9;CAP1;STXBP2;FLOT1;MAPK4;MINK1;ARHGAP33;MAP4K5
JNK signaling in the CD4+ TCR pathwayDBNL;MAP4K1
MAPK signaling pathwayFGF20;AKT2;MYCB;MAPK8IP2;GADD45G;FGF5;MAPKAPK3;PRKACBA;MAP2K1
Prostate CancerINS2;MTOR;KRAS;ATF4;FOXO1;IKBKB;TCF7;PIK3CG;GSTP1
Signaling events mediated by Stem cell factor receptor (c-Kit)SH2B3;MAP4K1;PTPRO;EVLA;STAP1
Signaling of Hepatocyte Growth Factor Receptor

MAP4K1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K1 itself. We selected most functions MAP4K1 had, and list some proteins which have the same functions with MAP4K1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX39;EPHB1;TRPM6;GM711;PIK3CB;PAK1;EPHA5;EIF4A1B;KIF23
MAP kinase kinase kinase kinase activityALPK2;MAP4K1;MAP4K2;MAP4K3;MAP4K5;MAP4K6
protein bindingRP9;COL3A1;CDAN1;ZBTB26;RAG1;SRSF2;DYRK1B;KRTAP13-3;HIST1H4B
protein kinase activityLTK;PRKD2;FGFR1A;SRPK1A;VSIG8B;CDK11A;KALRN;MAP3K4;TRIM28
protein serine/threonine kinase activitySGK2;STK24;CAMK2A;STK38A;NEK2;TTBK2;MAPK13;TLK2;SBK3

MAP4K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K1.

GRB2; PLCG1; NCK1; CRK

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