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MAP4K1

Official Full Name

mitogen-activated protein kinase kinase kinase kinase 1
Overview

Hematopoietic progenitor kinase 1(HPK1) is a member of the germinal center kinases that is predominantly expressed in hematopoietic cells. HPK1 is a key component linking T or B cell receptors to SAPK/JNK and IkappaB kinase pathways in lymphocytes. Throug
Synonyms

MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; hematopoietic progenitor kinase 1; HPK1; MEKKK 1; MEK kinase kinase 1; MAPK/ERK kinase kinase kinase 1;

Type

Recombinant Proteins

Species

Dog
Human
Human
Monkey
Mouse
Rat

Source

Insect Cell
Insect cells
Sf21
Sf9 Insect Cell

Tag

GST
GST,His
His
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP4K1-103H	Active Recombinant Human MAP4K1(1-346) Protein, C-His,N-GST-tagged	Sf21	GST,His	1-346 aa	Inquiry
Human	MAP4K1-27602TH	Recombinant Human MAP4K1	Sf9 Insect Cell	Non	346 amino acids	Inquiry
Human	MAP4K1-1041H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged	Sf9 Insect Cell	GST	1-346	$623 / 5μg $758 / 10μg
Human	MAP4K1-79H	Recombinant Human MAP4K1 Protein, GST-tagged	Insect cells	GST		Inquiry
Mouse	Map4k1-9520M	Active Recombinant Mouse Map4k1 Protein, GST-tagged	Insect cells	GST	1-346	Inquiry
Rat	MAP4K1-05R	Recombinant Rat MAP4K1 Protein, C-His tagged	Insect Cell	His		$319 / 25μg
Monkey	MAP4K1-03M	Recombinant Monkey MAP4K1 Protein, C-His tagged	Insect Cell	His		$298 / 5μg $398 / 10μg $998 / 50μg
Dog	MAP4K1-04D	Recombinant Dog MAP4K1 Protein, GST tagged	Insect Cell	GST		$298 / 5μg $398 / 10μg $998 / 50μg

Involved Pathway
Protein Function
Interacting Protein

MAP4K1 involved in several pathways and played different roles in them. We selected most pathways MAP4K1 participated on our site, such as B Cell Receptor Signaling Pathway, BCR signaling pathway, Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
B Cell Receptor Signaling Pathway	INPP5D;RELA;BLK;PPP3CA;PTPN18;ITPR2;SLA2;PRKCB;PPP3CC
BCR signaling pathway	DOK1;NETO2;MAP4K1;IBTK;CSK;MALT1;POU2F2;PAG1;CSNK2A1
Insulin Signaling	FLOT1;MINK1;GSK3AB;MAP3K10;INPP4AA;STXBP2;MAP4K5;RHOJ;KIF5B
JNK signaling in the CD4+ TCR pathway	DBNL;MAP4K1
MAPK signaling pathway	ARR3A;HSP70L;ARRB2A;PLA2G4A;MAPK9;MOS;CACNG6;Fgf15;TGFBR2
Prostate Cancer	CASP9;ARID1A;MAPK3;KRAS;CCND1;RB1;PIK3CB;FOXO1;CCNE1
Signaling events mediated by Stem cell factor receptor (c-Kit)	SH2B3;MAP4K1;EVLA;PTPRO;STAP1
Signaling of Hepatocyte Growth Factor Receptor

MAP4K1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K1 itself. We selected most functions MAP4K1 had, and list some proteins which have the same functions with MAP4K1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TAOK1;HSP90B1;MKNK2A;EHD2;GUCY2F;UBE2H;PC;KIF5A;IRAK1
MAP kinase kinase kinase kinase activity	MAP4K1;ALPK2;MAP4K3;MAP4K6;MAP4K2;MAP4K5
protein binding	CBY1;SIGIRR;STX6;IL1RAPL1;ACP1;MXD1;SOX7;ASF1B;GTF2F1
protein kinase activity	MAP3K12;RPS6KB1B;PRKACAA;PIK3R4;AKT3A;CDK11A;BSK146;RASSF2;CASKB
protein serine/threonine kinase activity	MAP3K9;BMPR1BB;OXSR1B;ILK;TGFBR1;TTN;DCLK1;MINK1;STRC

MAP4K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K1.

GRB2; PLCG1; NCK1; CRK