• Official Full Name

    mitogen-activated protein kinase kinase kinase kinase 1

  • Background

    Hematopoietic progenitor kinase 1(HPK1) is a member of the germinal center kinases that is predominantly expressed in hematopoietic cells. HPK1 is a key component linking T or B cell receptors to SAPK/JNK and IkappaB kinase pathways in lymphocytes. Throug
  • Synonyms

    MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; hematopoietic progenitor kinase 1; HPK1; MEKKK 1; MEK kinase kinase 1; MAPK/ERK kinase kinase kinase 1;
    • Type:
    • Recombinant Proteins
    • Species :
    • Dog
    • Human
    • Monkey
    • Mouse
    • Source :
    • Insect cell
    • Insect cells
    • Sf9 Insect Cell
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Dog MAP4K1-04D Recombinant Dog MAP4K-1 Protein Insect cell N/A
    Human MAP4K1-27602TH Recombinant Human MAP4K1 Sf9 Insect Cell N/A
    Human MAP4K1-1041H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged Sf9 Insect Cell GST
    Human MAP4K1-79H Recombinant Human MAP4K1 Protein, GST-tagged Insect cells GST
    Monkey MAP4K1-03M Recombinant Monkey MAP4K-1 Protein Insect cell N/A
    Mouse Map4k1-9520M Recombinant Mouse Map4k1 Protein, GST-tagged Insect cells GST
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    MAP4K1 involved in several pathways and played different roles in them. We selected most pathways MAP4K1 participated on our site, such as B Cell Receptor Signaling Pathway, BCR signaling pathway, Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling PathwayCD79B;BLK;GRB2;PIK3R2;LCP2A;LYN;IFITM1;ARPC4;PPP3CB
    BCR signaling pathwayCSNK2A1;CSK;PAG1;IBTK;DOK1;POU2F2;MAP4K1;MALT1;NETO2
    JNK signaling in the CD4+ TCR pathwayDBNL;MAP4K1
    Signaling events mediated by Stem cell factor receptor (c-Kit)SH2B3;STAP1;PTPRO;EVLA;MAP4K1
    Signaling of Hepatocyte Growth Factor Receptor

    MAP4K1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K1 itself. We selected most functions MAP4K1 had, and list some proteins which have the same functions with MAP4K1. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase kinase activityMAP4K3;ALPK2;MAP4K5;MAP4K1;MAP4K6;MAP4K2
    protein bindingKIF5A;RBP5;GRB10;TNNT1;SLC48A1;HAT1;BAZ1A;APPL1;CBLB
    protein kinase activityGSG2;PIK3CG;CSNK1G2B;CSNK1G3;BMPR1BA;ARAF;TLK1B;MAP3K11;FGFR1A
    protein serine/threonine kinase activityRPS6KA3A;MAP2K2A;RPS6KA2;OXSR1B;PAK2A;CDC42BPB;PAK4;CDC42BPA;Aatk

    MAP4K1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K1.

    GRB2; PLCG1; NCK1; CRK

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