Recombinant Human MAP4K1

Cat.No. : MAP4K1-27602TH
Product Overview : Recombinant fragment corresponding to amino acids 1-346 of Human MAP4K1 with an N terminal proprietary tag, MWt 65 kDa.
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Description : Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).
Protein length : 346 amino acids
Molecular Weight : 65.000kDa inclusive of tags
Source : Baculovirus infected sf9 cells
Tissue specificity : Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.
Biological activity : The Specific activity of MAP4K1-27602TH was determined to be 125 nmol/min/mg.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CNH domain.Contains 1 protein kinase domain.
Gene Name : MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Homo sapiens ]
Official Symbol : MAP4K1
Synonyms : MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; hematopoietic progenitor kinase 1; HPK1;
Gene ID : 11184
mRNA Refseq : NM_001042600
Protein Refseq : NP_001036065
MIM : 601983
Uniprot ID : Q92918
Chromosome Location : 19q13.1-q13.4
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; JNK signaling in the CD4+ TCR pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function : ATP binding; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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