Recombinant Human MAP4K1

• Cat.No.: MAP4K1-27602TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-346 of Human MAP4K1 with an N terminal proprietary tag, MWt 65 kDa.

Specification

• Description: Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).
• Protein length: 346 amino acids
• Molecular Weight: 65.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.
• Biological activity: The Specific activity of MAP4K1-27602TH was determined to be 125 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CNH domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Homo sapiens ]
• Official Symbol: MAP4K1
• Synonyms: MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; hematopoietic progenitor kinase 1; HPK1
• Gene ID: 11184
• mRNA Refseq: NM_001042600
• Protein Refseq: NP_001036065
• MIM: 601983
• Uniprot ID: Q92918
• Chromosome Location: 19q13.1-q13.4
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; JNK signaling in the CD4+ TCR pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity