Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged
| Cat.No. : | MAP4K1-1041H |
| Product Overview : | Recombinant human MAP4K1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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| Cat. No. : | MAP4K1-1041H |
| Description : | MAP4K1 or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. MAP4K1 is also known as mitogen-activated protein kinase kinase kinase kinase 1(MAP4K1). MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76. |
| Applications : | Kinase Assay; Western Blot |
| Molecular Weight : | 65 kDa |
| Expression System : | Sf9 insect cells using baculovirus. |
| Species : | Human |
| Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Specific Activity: : | 125 nmol/min/mg |
| Purity : | > 75 % |
| Concentration : | 0.1 ug/ul |
| Sequences : | 1-346 |
| Storage : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : | Ceramide signaling pathway; Direct p53 effectors; EPHB forward signaling; Insulin Signaling; MAPK signaling pathway; TNF receptor signaling pathway |
| Gene Name : | MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Homo sapiens ] |
| Official Symbol : | MAP4K1 |
| Synonyms : | MAP4K1; HPK1; mitogen-activated protein kinase kinase kinase kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; EC 2.7.11.1; hematopoietic progenitor kinase 1; Hematopoietic progenitor kinase; EC 2.7.11 |
| Gene ID : | 11184 |
| mRNA Refseq : | NM_007181 |
| Protein Refseq : | NP_009112 |
| MIM : | 601983 |
| UniProt ID : | Q92918 |
| Chromosome Location : | 19q13.1-q13.4 |
| Function : | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity |
Products Types
| ◆ Recombinant Protein | ||
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| Map4k1-9520M | Active Recombinant Mouse Map4k1 Protein, GST-tagged | +Inquiry |
| MAP4K1-04D | Recombinant Dog MAP4K1 Protein, GST tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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