Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1, GST-tagged

Cat.No. : MAP4K1-1041H
Product Overview : Recombinant human MAP4K1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : MAP4K1-1041H
Description : MAP4K1 or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. MAP4K1 is also known as mitogen-activated protein kinase kinase kinase kinase 1(MAP4K1). MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76.
Applications : Kinase Assay; Western Blot
Molecular Weight : 65 kDa
Expression System : Sf9 insect cells using baculovirus.
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Specific Activity: : 125 nmol/min/mg
Purity : > 75 %
Concentration : 0.1 ug/ul
Sequences : 1-346
Storage : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Ceramide signaling pathway; Direct p53 effectors; EPHB forward signaling; Insulin Signaling; MAPK signaling pathway; TNF receptor signaling pathway
Gene Name : MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Homo sapiens ]
Official Symbol : MAP4K1
Synonyms : MAP4K1; HPK1; mitogen-activated protein kinase kinase kinase kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; EC; hematopoietic progenitor kinase 1; Hematopoietic progenitor kinase; EC 2.7.11
Gene ID : 11184
mRNA Refseq : NM_007181
Protein Refseq : NP_009112
MIM : 601983
UniProt ID : Q92918
Chromosome Location : 19q13.1-q13.4
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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