Active Recombinant Mouse Map4k1 Protein, GST-tagged

Cat.No. : Map4k1-9520M
Product Overview : Recombinant mouse Map4k1 (1-346) protein with an N-terminal GST tag was expressed by baculovirus in Sf9 insect cells.
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Description : HPK1 or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. HPK1 is also known as mitogen-activated protein kinase kinase kinase kinase 1(MAP4K1). HPK1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76.
Source : Insect cells
Species : Mouse
Tag : GST
Bio-activity : The specific activity of HPK1 was determined to be 150.3 nmol/min/mg.
Molecular Mass : ~65 kDa
Purity : The purity of HPK1 was determined to be >90% by densitometry.
Applications : Kinase Assay, Western Blot
Stability : 1 year at -70 centigrade from date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.05 µg/µl
Storage Buffer : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, and 25% glycerol.
SDS-PAGE:
Gene Name : Map4k1
Official Symbol : Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 [ Mus musculus (house mouse) ]
Synonyms : Map4k1; mHPK1; MEKKK1; Hpk1; mitogen-activated protein kinase kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase kinase 1; HPK; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; hematopoietic progenitor kinase 1; EC 2.7.11.1
Gene ID : 26411
mRNA Refseq : NM_008279
Protein Refseq : NP_032305
UniProt ID : P70218

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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