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Recombinant Active Human MMP13 Protein, His-tagged(C-ter)

Cat.No. : MMP13-239H
Product Overview : Recombinant Active Human MMP13 Protein with His tag (C-ter) was expressed in HEK293.
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Description : This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Source : HEK293
Species : Human
Tag : His
Form : Powder
Bio-activity : Measured in a cell migration assay using A549 cells. 10 ng/mL of Recombinant Human MMP-13 can effectively induce A549 cells migration.
Protein length : Leu20-Cys471
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 95% (by SDS-PAGE)
Applications : FuncSt, SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 7.4)
Reconstitution : Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.
Gene Name : MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens ]
Official Symbol : MMP13
Synonyms : MMP13; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); collagenase 3; CLG3; MMP-13; MANDP1;
Gene ID : 4322
mRNA Refseq : NM_002427
Protein Refseq : NP_002418
MIM : 600108
UniProt ID : P45452

Not For Human Consumption!

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Reviews
12/05/2022

    Its reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.

    07/27/2020

      The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

      10/13/2016

        MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.

        Q&As (5)

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        Can MMP13 be a potential therapeutic target for cancer treatment? 04/17/2023

        Yes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.

        Is MMP13 involved in cardiovascular diseases? 05/29/2022

        Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.

        How does MMP13 contribute to cancer progression? 11/18/2021

        MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.

        How is genetic variation in MMP13 associated with disease susceptibility? 03/03/2019

        Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.

        Are there any clinical trials targeting MMP13? 08/30/2017

        Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.

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