Active Recombinant Human MMP-13, activated
Cat.No. : | MMP13-43H |
Product Overview : | Recombinant full-length human MMP-13 (EC 3.4.24.--) expressed in Spodoptera frugiperda (471 amino acid residues [1-mhpgvlaaf ------ rvmpansilw c-471], molecular weight 53820 Da). Swiss Prot P45452. This product is APMA activated, which had been removed after activation employing SEC and dialysis. The actMMP-13 shows predominately the app. 48-kDa form and faint the 50-kDa and app. 30-kDa form. |
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Source : | Spodoptera frugiperda |
Species : | Human |
Form : | 50 mM Tris pH 6.5, 250 mM NaCl, 5 mM CaCl2, 1 μM ZnCl2 |
Bio-activity : | >200 munits/mg (international unit 1 μmole/min/mg) |
Purity : | >95%, homogenous by SDS-PAGE |
Storage : | The enzyme can be kept at -80°C for many month. Repeated freezing and thawing must be avoided. Dilute and activate only the amount of enzyme you need, do not store enzyme in reaction buffer. The active 48 kDa enzyme undergoes very fast changes into a 30 kDa form which still retains enzymatic characteristics of the 48 kDa enzyme. |
Tag : | Non |
Gene Name : | MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens ] |
Official Symbol : | MMP13 |
Synonyms : | MMP13; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); collagenase 3; CLG3; MMP-13; MANDP1; |
Gene ID : | 4322 |
mRNA Refseq : | NM_002427 |
Protein Refseq : | NP_002418 |
MIM : | 600108 |
UniProt ID : | P45452 |
Chromosome Location : | 11q22.3 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; |
Function : | calcium ion binding; calcium-dependent protein binding; fibronectin binding; low-density lipoprotein particle receptor binding; metalloendopeptidase activity; peptidase activity; zinc ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.
The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.
MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.
Q&As (5)
Ask a questionYes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.
Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.
MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.
Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.
Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.
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