Recombinant Human MMP13 Protein (Leu20-Cys471), N-His tagged

• Cat.No.: MMP13-4575H
• Product Overview: Recombinant human MMP13 (Leu20-Cys471) fused with the N-His tag was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 53.99 kDa
• Protein Length: Leu20-Cys471
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02% NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens (human) ]
• Official Symbol: MMP13
• Synonyms: MMP13; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); collagenase 3; CLG3; MMP-13; MANDP1
• Gene ID: 4322
• mRNA Refseq: NM_002427
• Protein Refseq: NP_002418
• MIM: 600108
• UniProt ID: P45452

Reviews

12/05/2022

Its reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.

07/27/2020

The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

10/13/2016

MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.

Q&As

Can MMP13 be a potential therapeutic target for cancer treatment?

Yes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.

Is MMP13 involved in cardiovascular diseases?

Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.

How does MMP13 contribute to cancer progression?

MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.

How is genetic variation in MMP13 associated with disease susceptibility?

Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.

Are there any clinical trials targeting MMP13?

Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.