Recombinant Human matrix metallopeptidase 13 (collagenase 3), His-tagged
Cat.No. : | MMP13-443H |
Product Overview : | MMP13, 104- 471aa, Human, His tag, E.coli |
- Specification
- Gene Information
- Related Products
Description : | MMP13 of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Recombinant human MMP13 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.15M NaCl, 1mM DTT |
Molecular Mass : | 44.7 kDa (391aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSYNVFPRT LKWSKMNLTY RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR GRKFWALNGY DILEGYPKKI SELGLPKEVK KISAAVHFED TGKTLLFSGN QVWRYDDTNH IMDKDYPRLI EEDFPGIGDK VDAVYEKNGY IYFFNGPIQF EYSIWSNRIV RVMPANSILW C |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Bradford assay) |
Gene Name : | MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens ] |
Official Symbol : | MMP13 |
Synonyms : | MMP13; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); collagenase 3; CLG3; MMP-13; MANDP1; |
Gene ID : | 4322 |
mRNA Refseq : | NM_002427 |
Protein Refseq : | NP_002418 |
MIM : | 600108 |
UniProt ID : | P45452 |
Chromosome Location : | 11q22.3 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; |
Function : | calcium ion binding; calcium-dependent protein binding; fibronectin binding; low-density lipoprotein particle receptor binding; metalloendopeptidase activity; peptidase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP13-0832H | Recombinant Human MMP13 Protein (E103-N274), Tag Free | +Inquiry |
MMP13-01H | Active Recombinant Human MMP13 (F175D) Protein | +Inquiry |
MMP13-2448H | Recombinant Human MMP13 Protein, His-tagged | +Inquiry |
MMP13-4451H | Recombinant Human MMP13 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP13-0833H | Recombinant Human MMP13 Protein (E103-N274), His tagged | +Inquiry |
◆ Lysates | ||
MMP13-4280HCL | Recombinant Human MMP13 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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