NFATC2

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
  • Synonyms

    NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;nuclear factor of activated T-cells, cytoplasmic 2;NF ATP;NFAT1;NFATp;NF-ATc2;NFAT pre-existing subunit;T cell transcription factor NFAT1;T-cell transcription factor

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • E.coli
  • Mammalian Cells
  • DDK
  • Myc
  • His
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
NFATC2-181H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NFATC2-182H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NFATC2-18H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NFATC2-29251TH Recombinant Human NFATC2, His-tagged E.coli Human His 320-849 a.a.
NFATC2-2740HFL Recombinant Full Length Human NFATC2 protein, Flag-tagged Mammalian Cells Human Flag Full L.
NFATC2-3619H Recombinant Human NFATC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NFATC2-391H Recombinant Human NFATC2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Nfatc2-4388M Recombinant Mouse Nfatc2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway,Wnt signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxytocin signaling pathway CACNG4,MYLK2,GNAI2,MAP2K5,PRKCA,CAMK4,CAMKK2,CAMK2D,HRAS,RAF1
    Hepatitis B IKBKE,RB1,TLR4,PIK3CD,IFNA5,Ifna15,TGFB1,IRF3,AKT2,MAP2K2
    Axon guidance SHB,Ntng2,MET,NRG2A,CLTC,Plxna2,FGFR1B,CSF2,PPP3R1,ACTR2B
    VEGF signaling pathway PPP3CC,NOS3,MAPKAPK2,PTK2AB,PLA2G4A,PIK3R5,VEGFAB,VEGFA,MAP2K2A,HRASA
    cGMP-PKG signaling pathway SLC8A1,CREB3L1,RHOA,ROCK2,KCNJ8,CALM1,PPP1CA,AKT1,ATF4,PIK3CB
    B Cell Receptor Signaling Pathway PPP3R1,DUSP4,MAP2K2,ITK,CDK6,HRAS,Cd79a,BLK,CD79A,RAC3
    Natural killer cell mediated cytotoxicity ICAM1,KLRC4-KLRK1,IFNA4,IFNA1,IFNA12,VAV3,NCR3,HLA-E,PIK3R1,ITGB2
    T cell receptor signaling pathway IL4,MAP2K1,LAT,MAP3K7,PTPRC,PIK3R2,DEF6A,VAV2,MAP2K2,IKBKB
    Wnt signaling pathway FOSL1,WNT5B,FBXW2,NLK1,SFRP1,WNT2BA,SFRP4,WNT2BB,PPARD,PRKACA

    Protein Function

    NFATC2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding CHD8,ZFAND5,DBX1B,ZFP410,ZFP131,ATOH7,XRCC6,ZNF461,NFYC,NFYAL
    chromatin binding MTA1,PRDM13,SP3,HDAC2,RUNX2,PPARGC1A,BAZ1B,HMG20A,HMGN5,RELB
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding FOSB,NPAS4,TLX1,RAX,MEIS3,ELF4,ZFP750,SRF,DDIT3,NR3C1
    transcription factor activity, sequence-specific DNA binding E2F1,SIX3,TBPL2,CREB3L3A,HOXA5A,TEFB,EOMESA,RUNX1T1,TFDP1,NFIL3
    transcription factor binding E2F2,DDX3X,NR0B2,HDAC7,MYBBP1A,TFDP1A,PPP1R13B,DIP2B,PAX2,ARID5A
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FOS,PER1,PHOX2B,CREB3L2,FOSL1,AKNA,MYF6,NKX6,SMAD4,ATF4
    protein binding HNF1B,BCKDHB,GALT,ELAVL1,CUL9,LYRM2,ICA1,FASTK,CCDC87,FAAH
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ZFPM2,ZGPAT,ZBTB20,EN1,SALL1,NR1D1,PROX1B,TBX3,NACC2,HSF1

    Interacting Protein

    NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.

    VRK2;VRK2;arre2_element_mouse_il2_promoter;LRRK2;il2_human_gene;ccl5-derived_putative-nfat-site_dna-probe

    NFATC2 Related Signal Pathway

    Resources

    References

    • Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
    • Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).

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