NFATC2

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
  • Synonyms

    NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;nuclear factor of activated T-cells, cytoplasmic 2;NF ATP;NFAT1;NFATp;NF-ATc2;NFAT pre-existing subunit;T cell transcription factor NFAT1;T-cell transcription factor

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • E.coli
  • Mammalian Cells
  • DDK
  • Myc
  • His
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
NFATC2-181H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NFATC2-182H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NFATC2-18H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NFATC2-29251TH Recombinant Human NFATC2, His-tagged E.coli Human His 320-849 a.a.
NFATC2-2740HFL Recombinant Full Length Human NFATC2 protein, Flag-tagged Mammalian Cells Human Flag Full L.
NFATC2-3619H Recombinant Human NFATC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NFATC2-391H Recombinant Human NFATC2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Nfatc2-4388M Recombinant Mouse Nfatc2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway,Wnt signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity FCGR4,SAMD3,KLRK1,PTPN11,HLA-C,SHC1,NRAS,SHC2,IFNA2,IFNA16
    Hepatitis B TP53,CYCS,PIK3CA,TIRAP,TRP53,AKT2,TNF,IFNA4,IFNA7,MAP2K4
    cGMP-PKG signaling pathway RGS2,ROCK2,ATP1A3,MYLK3,SRF,PIK3R2,PDE3B,CALM2,MEF2B,PIK3R5
    HTLV-I infection ANAPC2,AKT1,XIAP,VDAC1,NFATC1,IL1R1,FDPS,VCAM1,RANBP3,PDGFRB
    Oxytocin signaling pathway RYR3,RHOA,PPP1CB,CAMK2A,CACNG8,EEF2K,PLCB3,CACNB2,TRPM2,PTGS2
    Osteoclast differentiation CALCR,PIK3R1,CYBA,LILRB3,FCGR1,FCGR1A,GRB2,IFNAR2,LILRB1,LILRA2
    B Cell Receptor Signaling Pathway BCL10,CD79A,PDPK1A,DUSP4,NRAS,PLCG2,RASGRP3,FOS,DOK3,NFKB1
    VEGF signaling pathway KRAS,MAPKAPK2,NOS3,PRKCA,MAPK11,RAC1,PIK3R5,PLA2G4AA,MAPK12,PIK3R2
    T cell receptor signaling pathway MAP2K7,HRAS,CD247,MAPK11,GRAP2,LCP2,CD8B1,EVLB,PIK3R5,MUC1

    Protein Function

    NFATC2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZFP536,TBX20,ARID3B,TCF12,MEF2B,TFAP2A,POU4F3,FOXA2,SALL1,NFE2L3
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HOXA7,MEIS3,EHF,ETV2,FOXJ1,PATZ1,FOXA1,HOXA10,GLI2,NPAS4
    transcription factor binding PIK3R1,RB1,CEBPA,PAX6,NFKB1,LMO4,NLK,ETS1,NAAA,SLC26A5
    chromatin binding MAZ,YBX2,SIRT6,TWIST2,RBMX,PARP1,TOX2,MTA3,PHF8,FOXC1A
    protein binding ZHX1,TMSB4X,SMAP2,RTP3,SNRNP70,HIRIP3,TP53,SLIT2,FAM125A,ZBED1
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NR2C1,BATF3,PPARA,HOXA2,TBX15,CTCF,BTG2,REST,YY1,OVOL1
    transcription factor activity, sequence-specific DNA binding ZSCAN4,ZNF691,LCOR,STAT5A,SIX1B,VED,ZNF354B,NKX6-1,NFIL3,ZNF133
    DNA binding POLR2EB,DTD1,HOXA13A,HOXB5A,ARID5A,LHX1A,Rhox5,FOXA1,NKX3-1,ZFP541

    Interacting Protein

    NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.

    VRK2;VRK2;arre2_element_mouse_il2_promoter;LRRK2;il2_human_gene;ccl5-derived_putative-nfat-site_dna-probe

    NFATC2 Related Signal Pathway

    Resources

    References

    • Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
    • Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).

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