NFATC2
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Official Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -
Overview
The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an -
Synonyms
NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;nuclear factor of activated T-cells, cytoplasmic 2;NF ATP;NFAT1;NFATp;NF-ATc2;NFAT pre-existing subunit;T cell transcription factor NFAT1;T-cell transcription factor
Recombinant Proteins
- Human
- Mouse
- HEK293
- E.coli
- Mammalian Cells
- DDK
- Myc
- His
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFATC2-181H | Recombinant Human NFATC2 protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| NFATC2-182H | Recombinant Human NFATC2 protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| NFATC2-18H | Recombinant Human NFATC2 protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| NFATC2-29251TH | Recombinant Human NFATC2, His-tagged | E.coli | Human | His | 320-849 a.a. |
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| NFATC2-2740HFL | Recombinant Full Length Human NFATC2 protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| NFATC2-3619H | Recombinant Human NFATC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| NFATC2-391H | Recombinant Human NFATC2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Nfatc2-4388M | Recombinant Mouse Nfatc2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway,Wnt signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | KCNJ8,GNA11,PIK3R1,KCNMB3,GATA4,ATP1A3,IRS2,ATF4,MEF2A,PLCB2 |
| T cell receptor signaling pathway | LAT,CD8B1,SOS1,CABIN1,MUC1,MAP3K14,CD40LG,EVLB,NCK2,PAK7 |
| Axon guidance | EPHB4A,ACTR3,SCN4A,GNAI2,AP2M1,NRG2A,MYL12B,SHB,SEMA4A,RHOGA |
| Hepatitis B | NFATC4,IKBKB,STAT5A,IFNA7,MAVS,IFIH1,NFATC3,PTK2B,EGR2,YWHAB |
| Osteoclast differentiation | IFNB1,FOSB,TGFB2,TYK2,SFPI1,SIRPG,RELB,MAP2K1,SPI1,ACP5 |
| HTLV-I infection | TGFB2,MAP2K4,ATF3,HLA-DOB,VDAC1,POLD1,POLD2,HLA-DMB,ETS1,CCNB2 |
| Wnt signaling pathway | MAPK10,BAMBIA,SOX17,MMP7,NKD2B,NLK2,PPP3CCA,GSK3AA,BTRC,LRP6 |
| Oxytocin signaling pathway | PRKAG3,EEF2K,MAPK3,NFATC3,PLCB1,KRAS,NPR2,PRKCA,PIK3CB,CAMK2B |
| Natural killer cell mediated cytotoxicity | NCR2,ULBP1,PIK3CA,PIK3CG,MICB,PPP3CA,IFNA1,IFNAR2,BRAF,IFNA16 |
Protein Function
NFATC2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MEF2A,RFX5,DLX5,GLI3,SP1,AKNA,MITFA,ELF1,HOXA7,TBX20 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PITX2,ONECUTL,RAX,NR3C1,NEUROD6,NKX2,Ar,PATZ1,RELA,NOBOX |
| chromatin binding | NR5A1A,TMPOA,TCF7L1B,SFPQ,POLA1,TRP53,DNMT3B,ING2,SETD7,CNBPA |
| transcription factor binding | PARD6A,ARRB1,PDX1,RNF222,MYC,TAF1,TP73,CTNNB1,STK4,SOST |
| transcription factor activity, sequence-specific DNA binding | FOXA1,MKL1,PPARD,MYCLB,TCF4,PBX1A,PTF1A,DMRTC2,NFE2L1,GATA2 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | POU4F2,AEBP2,ESRRA,SNAI1,NFIL3-2,PYDC3,NFIL3,PROX1B,NEUROG3,SP3 |
| protein binding | GABPB2,CRP,GEMIN4,PELI3,C16orf48,TRIB3,ZNF581,TAF1,CASP9,SLC1A2 |
| DNA binding | MESP1,SNAPC4,HOXA13A,MIER3,HOXA9A,SOX8,POLR1E,RUNX2B,ZFP1,POU3F3A |
Interacting Protein
NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.
VRK2;VRK2;arre2_element_mouse_il2_promoter;LRRK2;il2_human_gene;ccl5-derived_putative-nfat-site_dna-probe
NFATC2 Related Signal Pathway
Resources
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References
- Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
- Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).
