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NFATC2

Official Full Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Overview

The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
Synonyms

NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, cytoplasmic 2; NF ATP; NFAT1; NFATp; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor;

Type

Recombinant Proteins

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mamanlian cells

Tag

Flag
His
Myc
DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFATC2-18H	Recombinant Human NFATC2 protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	NFATC2-29251TH	Recombinant Human NFATC2, His-tagged	E.coli	His	320-849	Inquiry
Human	NFATC2-181H	Recombinant Human NFATC2 protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	NFATC2-182H	Recombinant Human NFATC2 protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	NFATC2-2740HFL	Recombinant Full Length Human NFATC2 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	NFATC2-3619H	Recombinant Human NFATC2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	NFATC2-391H	Recombinant Human NFATC2 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	Myc&DDK		Inquiry
Mouse	Nfatc2-4388M	Recombinant Mouse Nfatc2 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
NFATC2 Related Signal Pathway

NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway, Wnt signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	ROCK2;TRPC6;ITPR3;PPP3R2;PPIF;PRKG1;SLC25A31;PDE2A;LOC100328615
Wnt signaling pathway	WNT11R;TCF7L1A;WNT2;WNT10B;PRKACAB;NFATC1;MYCB;PORCN;WNT8A
Axon guidance	FYN;CREB1B;SEMA3E;LIMK1;ITSN1;SPNA1;SRGAP1;MAPK3;KIF4
VEGF signaling pathway	PIK3R3A;PIK3CB;PRKCBA;HRAS;PPP3CC;MAP2K1;PTK2AA;PLA2G4D;PRKCA
Osteoclast differentiation	PIK3R5;MAPK3;MAPK8;BTK;NCF4;MAPK13;IFNAR2;LILRB4;PLCG2
Natural killer cell mediated cytotoxicity	MICB;KIR2DL1;KLRA8;TYROBP;RAET1D;Ifna15;IFNA7;NFATC2;GRB2
T cell receptor signaling pathway	PIK3CB;NFATC3;PLCG1;IKBKB;NFKB1;CDC42;TNF;CABIN1;DBNLB
B cell receptor signaling pathway	NFKB1;SLA2;LYN;CD72;CD79A;CDK4;CTNNB2;BCL10;IGHM
Oxytocin signaling pathway	PPP3R2;GNAQ;PPP1CC;PPP1R12C;GNAS;PLCB1;GUCY1A3;ITPR1;MYLK2
Hepatitis B	CCNA2;CCND1;MAPK1;TBK1;ATP6AP1;MAP2K4;TGFBR1;CASP9;CCNA1
HTLV-I infection	FZD8;IKBKG;PRKACA;PIK3R5;SLC25A31;POLB;Fzd4;HLA-C;DLG1

NFATC2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	THRAA;MXD4;ZNF689;DNMT1;NR2F5;CTCFL;ADNPA;TXLNB;ZNF729
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GMEB2;NR3C1;MEF2A;IRF4;ETV6;CTCF;OTX2;STAT3;KCNIP3
chromatin binding	TOX3;ATAD2B;NR5A1B;HMGB3B;NFIA;PPARGC1A;HMGB3;SP140L;KAT2B
protein binding	TEX14;SGCA;PEBP1;SNX27;SIN3A;STARD13;PRKCI;SARM1;TBC1D23
transcription factor activity, sequence-specific DNA binding	FOXG1D;NR6A1B;RORA;ZNF354A;LHX1A;ATF4;GATA1A;RB1;NFYC
transcription factor binding	PPP1R13L;EPAS1;TAF7;CAMTA2;NFKBIA;HYAL1;APBB3;VDRA;TAF12
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	IRF4;KLF5;SPI1;PAX8;NDN;FOXK2;HOXA10;MEIS1;SOX1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	TBX15;NKX6-1;PROX1;CUX2;HOXA2;BATF3;GATA1;BHLHE40;TFAP2C

NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.

VRK2; VRK2; arre2_element_mouse_il2_promoter; LRRK2; il2_human_gene; ccl5-derived_putative-nfat-site_dna-probe

Research Area

Transcription Regulators in VSMC

T Cell Cytokine Signaling

Hematopoietic Stem Cell Transcription Factors and Regulators

Mesenchymal Stem Cell Transcription Factors

Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).

Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).