NFATC2

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an

  • Synonyms

    NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;nuclear factor of activated T-cells, cytoplasmic 2;NF ATP;NFAT1;NFATp;NF-ATc2;NFAT pre-existing subunit;T cell transcription factor NFAT1;T-cell transcription factor

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • E.coli
  • Insect Cells
  • Mammalian Cells
  • DDK
  • Myc
  • His
  • Flag

    Involved Pathway

    NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway,Wnt signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway PDK2B, Cd79b,IGHM,DUSP4,CDK7,MAPK3,CDK2,RAF1,PIK3R3,CD19
    cGMP-PKG signaling pathway NPR1,MAPK1,PLCB3,RHOA,GUCY1B3,CALM3,PLCB2,MAP2K2,ATP1B3,INSR
    T cell receptor signaling pathway NFATC3,Il2,GRAP2,PIK3CD,MAPK3,PIK3R3,PPP3CB,NFKBIE,DBNLB,RAF1
    Oxytocin signaling pathway CACNG1,RYR1,PPP1CA,ITPR3,CACNG4,PLA2G4A,PRKAG3,MYLK4,GNAO1,CACNG7
    HTLV-I infection PDGFRB,HLA-B,PPP3R1,BUB1B,ZFP36,KAT2A,WNT5A,POLE4,TSPO,MAP3K14
    Hepatitis B IKBKB,IFNB1,RB1,MAPK9,CREB3L3,MAP3K1,TGFB3,TGFBR1,MAPK1,IKBKG
    Wnt signaling pathway PRKACB,LEF1,SFRP1,WNT7A,TCF7,FZD7A,CAMK2D,SFRP2,MAPK8,DVL3A
    Osteoclast differentiation NFKB1,SIRPG,FOSL1,IL1B,SIRP-BETA,IFNGR2,MAP2K6,CYLD,PIK3CG,SOCS3
    Axon guidance DNM1,RHOA,SEMA3B,SPTB,RAC1,PPP3CB,CXCR4,Unc5b,NTN4,RASGRP4

    Protein Function

    NFATC2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding RAX,NEUROD1,NEUROD6,ATF3,NFKB2,TCF3B,ZNF680,TFAP4,ISL1,DPF2
    transcription factor binding STAT3,SIRT2,HMGB1,PARK7,GCM1,MDFIC,TCF12,KAT2B,FIGLA,CAMTA2
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RELA,HAND1,ZKSCAN3,ZBTB7A,PYDC3,ESRRA,BCL11A,NFIL3-6,MXD1,JDP2
    DNA binding POLA1,CEBPA,IRF7,MSL3,PHOX2BA,POLR3F,JUNB,AHR2,RBM5,H2AFB1
    chromatin binding JDP2,URI1,GATA2B,NFIA,SUPT5H,ZEB1,PHF13,PPARGC1A,SOX15,BRD2
    protein binding TXNIP,AAGAB,RPSA,TRAM1,UBXN8,RAB11B,GPSM2,OTUB1,MGARP,ATCAY
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ATF2,NCOA3,ETV2,PATZ1,MTF1,EPAS1,GLI3,POU4F3,MEF2A,TCF21
    transcription factor activity, sequence-specific DNA binding MYRFL,ZNF668,ZNF577,PRDM15,TCF7,NFE2L2A,SIM1A,TADA2A,MAFGA,IRF6

    Interacting Protein

    NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.

    VRK2;VRK2;arre2_element_mouse_il2_promoter;LRRK2;il2_human_gene;ccl5-derived_putative-nfat-site_dna-probe

    NFATC2 Related Signal Pathway

    Resources

    Research Area

    References

    • Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
    • Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).

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