Recombinant Human NFATC2 protein, MYC/DDK-tagged

Cat.No. : NFATC2-181H
Product Overview : Recombinant Human NFATC2, transcript variant D, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Source : HEK293
Species : Human
Tag : Myc&DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 97.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [ Homo sapiens ]
Official Symbol : NFATC2
Synonyms : NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, cytoplasmic 2; NF ATP; NFAT1; NFATp; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor NFAT1; NFAT transcription complex, preexisting component; preexisting nuclear factor of activated T-cells 2; nuclear factor of activated T-cells, preexisting component; NFATP;
Gene ID : 4773
mRNA Refseq : NM_001136021
Protein Refseq : NP_001129493
MIM : 600490
UniProt ID : Q13469
Chromosome Location : 20q13.2
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem;
Function : DNA binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding;

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