NLRP3

  • Official Full Name

    NLR family, pyrin domain containing 3

  • Overview

    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 UTR splice patterns are biologically valid.
  • Synonyms

    NLRP3; NLR family, pyrin domain containing 3; C1orf7, CIAS1, cold autoinflammatory syndrome 1; NACHT, LRR and PYD domains-containing protein 3; AGTAVPRL; AII; AVP; CLR1.1; Cryopyrin; FCAS; FCU; MWS; NALP3; nucleotide binding oligomerization domain; leuci;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • FLAG
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NLRP3-185H Recombinant Human NLRP3 protein, GST-tagged Wheat Germ GST
Human NLRP3-186H Recombinant Human NLRP3 protein, GST-tagged Wheat Germ GST
Human NLRP3-3799HCL Recombinant Human NLRP3 293 Cell Lysate HEK293 N/A
Human NLRP3-01H Recombinant Human NLRP3 Protein, His/FLAG-tagged Insect Cell His/FLAG 2-1036(end)
Human NLRP3-02H Recombinant Human NLRP3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human NLRP3-2493H Recombinant Human NLRP3 Protein, His-tagged E.coli N-His Cys770-Trp1036
Human NLRP3-01HE Recombinant Human NLRP3 Protein, His-tagged E.coli His
Human NLRP3-1518H-B Recombinant Human NLRP3 Protein Pre-coupled Magnetic Beads HEK293
Human NLRP3-3835H Recombinant Human NLRP3 protein, His-tagged E.coli His 937-1036 aa
Human NLRP3-3003H Recombinant Human NLRP3 protein, His-SUMO-tagged E.coli N-His-SUMO 733-1036aa
Human NLRP3-1422H Recombinant Human NLRP3 protein, His-tagged E.coli His 29-231aa
Human NLRP3-4645H Recombinant Human NLRP3 protein, His-tagged E.coli His 1-536aa
Human NLRP3-569HFL Recombinant Full Length Human NLRP3 Protein, C-Flag-tagged Mammalian cells Flag
Human NLRP3-1518H Recombinant Human NLRP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NLRP3-3987H Recombinant Human NLRP3 Protein (Met1-Arg157), N-His tagged E.coli N-His Met1-Arg157
Mouse NLRP3-10722M Recombinant Mouse NLRP3 Protein Mammalian Cell His
Mouse Nlrp3-1748M Recombinant Mouse Nlrp3 protein, His-tagged E.coli His Cys671~Trp1033
Mouse NLRP3-6097M Recombinant Mouse NLRP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nlrp3-4651M Recombinant Mouse Nlrp3 protein, His-SUMO-tagged E.coli His-SUMO 1-153aa
Mouse NLRP3-6097M-B Recombinant Mouse NLRP3 Protein Pre-coupled Magnetic Beads HEK293
Mouse NLRP3-10722ME Recombinant Mouse NLRP3 Protein, His tagged E.coli His
Rhesus Macaque NLRP3-3047R Recombinant Rhesus monkey NLRP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NLRP3-2866R Recombinant Rhesus Macaque NLRP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NLRP3-2866R-B Recombinant Rhesus Macaque NLRP3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

NLRP3 involved in several pathways and played different roles in them. We selected most pathways NLRP3 participated on our site, such as Immune System, Inflammasomes, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Immune SystemCD200R4;TPP2;CYLD;NLRP3;KLHL21;AP1G1;LILRA3;CLEC4A;IFIT2
InflammasomesBTR12;PANX1;TXN;SUGT1;Txn1;TXNIP;PANX1A;BTR22;BTR18
Influenza ATNFRSF10C;IFNGR2;IL1B;FAS;OAS3;IFNAR1;HLA-DPB1;H2-AA;HLA-DQA2
Innate Immune SystemDEFB4B;PANX1A;LGALS3;HERC5;WIPF2;POLR3F;LAT2;TXNIPA;DDX41
NOD pathwayNLRP2;PRDM1;SUGT1;AAMP;COPS6;NLRP3;NLRP12;NLRP4;NLRP7
NOD-like receptor signaling pathwayNAIP7;NFKBIA;TRIP6;MAPK12;TRAF6;CARD9;NFKBIAA;MAPK8;TNF
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysBTR30;BTR06;PANX1B;BTR29;BTR09;NLRP3;TXNIPB;TXNIPA;PANX1A
PertussisIl23a;CXCL6;C4BPB;ITGB2;C5;CALM2;MAPK1;C4BPA;NLRP3

NLRP3 has several biochemical functions, for example, ATP binding, peptidoglycan binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP3 itself. We selected most functions NLRP3 had, and list some proteins which have the same functions with NLRP3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSMYHC3;NLRP3;UBE2L3;MYO6B;ABCA8;ATP8B1;ADCK3;EGFR;EPHA10
peptidoglycan bindingRNASE7;PGLYRP3;NOD1;TREM2;PGLYRP1;PGLYRP4;TLR2;NLRP3;PGLYRP2
protein bindingNOP2;SOX9A;STBD1;PCSK2;SPTSSB;PTPLAD1;FBXO25;IRF5;RARRES2
sequence-specific DNA bindingRARGB;FOXE3;CENPB;Trl;ENG1B;BCL2;SIX4B;SIX9;OTPB
transcription factor bindingGATA6;TMEM173;ARID5A;PPRC1;GCM1;SUFU;FOXF2;HES6;KEAP1B

NLRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP3.

PYCARD; MAVS; PHRF1; AP3B1; GEMIN2; UQCRQ; SMARCA5; URB1

Research Area

Related articles

Santoni, G; Cardinali, C; et al. Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. JOURNAL OF NEUROINFLAMMATION 12:-(2015).
Beshir, S; Shaheen, WA; et al. Serum Autoantibodies in Silicosis and Non-Silicosis Cement Workers. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 58:238-244(2015).
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