Recombinant Human NRAS Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : NRAS-3519H
Product Overview : NRAS MS Standard C13 and N15-labeled recombinant protein (NP_002515) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 21.2 kDa
AA Sequence : MTEYKLVVVGAGGVGKSALTIQLIQ NHFVDEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQYMRTG EGFLCVFAINNSKSFADINLYREQI KRVKDSDDVPMVLVGNKCDLPTRTV DTKQAHELAKSYGIPFIETSAKTRQ GVEDAFYTLVREIRQYRMKKLNSSD DGTQGCMGLPCVVMTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : NRAS NRAS proto-oncogene, GTPase [ Homo sapiens (human) ]
Official Symbol : NRAS
Synonyms : NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog; GTPase NRas; N ras; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog; NS6; ALPS4; N-ras; NRAS1;
Gene ID : 4893
mRNA Refseq : NM_002524
Protein Refseq : NP_002515
MIM : 164790
UniProt ID : P01111

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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