PRKDC
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Official Full Name
protein kinase, DNA-activated, catalytic polypeptide
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Overview
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010] -
Synonyms
PRKDC; protein kinase, DNA-activated, catalytic polypeptide; HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; p460; DNA-PK catalytic subunit; hyper-radiosensitivity of murine scid mutation, complementing 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- E.coli
- HEK293
- HeLa
- Insect Cell
- Mammalian Cell
- Mammalian cell line.
- Wheat Germ
- Flag
- His
- His (Fc)
- Avi
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PRKDC-64HFL | Active Recombinant Full Length Human PRKDC Protein, Flag-tagged | Mammalian cell line. | Flag | Full Length |
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| Human | PRKDC-860H | Recombinant Human PRKDC Protein | HeLa | N/A |
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| Human | PRKDC-28357TH | Recombinant Human PRKDC | Wheat Germ | N/A | 110 amino acids |
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| Human | PRKDC-859H | Recombinant Human PRKDC Protein | Insect Cell | N/A |
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| Human | PRKDC-3252H | Recombinant Human PRKDC protein, His-tagged | E.coli | His | 3979-4128 aa | |
| Mouse | PRKDC-13375M | Recombinant Mouse PRKDC Protein | Mammalian Cell | His |
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| Mouse | Prkdc-3370M | Recombinant Mouse Prkdc protein, His-tagged | E.coli | His | 3747-4015aa |
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| Mouse | PRKDC-7100M | Recombinant Mouse PRKDC Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | PRKDC-7100M-B | Recombinant Mouse PRKDC Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Prkdc-1774M | Recombinant Mouse Prkdc protein, His & T7-tagged | E.coli | His/T7 | Ala3899~Met4128 (Accession # P97313) |
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| Chicken | PRKDC-6226C | Recombinant Chicken PRKDC | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PRKDC Related Articles
- PRKDC Related Research Area
PRKDC involved in several pathways and played different roles in them. We selected most pathways PRKDC participated on our site, such as Non-homologous end-joining, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-homologous end-joining | XRCC5;PRKDC;DNTT;NHEJ1;XRCC6;MRE11A;POLM;FEN1;DCLRE1C |
| Cell cycle | CDC27;CENPQ;CCND3;CDC6;MIS12;MCPH1;MCM2;CCNB2;SMARCA5 |
PRKDC has several biochemical functions, for example, ATP binding, DNA-dependent protein kinase activity, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKDC itself. We selected most functions PRKDC had, and list some proteins which have the same functions with PRKDC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TNK1;P2RX3B;PKM2;BTK;MYO15;ABCC12;AK7;ENTPD3;NDUFA13 |
| DNA-dependent protein kinase activity | PRKDC;ALPK2;ATM;XRCC6BP1;HMGA2 |
| double-stranded DNA binding | MTERFD2;SAFB;MTERF2;MEN1;PNKP;RAD51L1;MTERF;SETMAR;NEIL3 |
| enzyme binding | ERN1;CREB1;APBA3;ATP6AP2;IL6R;HDAC10;BACE1;DAOA;GSTM4 |
| poly(A) RNA binding | RPS23;RBM47;FRG1;STRAP;SAMSN1;EIF5;DHX37;SART3;SRSF7 |
| protein binding | PRR13;MKNK1;STX18;ZNF511;Ar;OSBPL3;SPINK1;ATL1;LCP2 |
| protein kinase activity | GRK1B;PAK4;ZNF143B;SNRKB;NTRK2B;PRKACBA;PTK7A;EIF2AK2;NPR2 |
| protein serine/threonine kinase activity | MAP3K12;ULK3;HIPK1;TGFBR1;TESK2;PAK4;PRKAA2;NEK5;SLK |
| transcription factor binding | PITX2;TRERF1;EPN1;RBFOX2;UBN1;MLXIPL;PYDC3;PARP1;CTNNB1 |
PRKDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKDC here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKDC.
XRCC6; XRCC5; PIDD1; CASP2
- Q&As
- Reviews
Q&As (5)
Ask a questionPRKDC consists of an N-terminal helical domain, a circular cradle domain containing multiple HEAT repeats and a large number of conserved phosphorylation clusters, and a C-terminal domain containing a highly conserved kinase architecture.
PRKDC is involved in lymphocyte development, antibody V(D)J recombination, immunoglobulin and T-cell receptor gene assembly, and the establishment of the central immune tolerance system.
PRKDC is relevant to the study of breast cancer, gastric cancer, liver cancer and other diseases.
Lack of PRKDC gene function will lead to symptoms of immunodeficiency.
PRKDC is usually connected to His, and we will adapt it to your needs!
Customer Reviews (3)
Write a reviewThe product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.
The purchased antibodies were very sensitive and helped me to get satisfactory experimental results.
Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.
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