S100A6
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Official Full Name
S100 calcium binding protein A6 -
Overview
Protein S100-A6 is a protein that in humans is encoded by the S100A6 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. -
Synonyms
S100A6;2A9;5B10;CABP;CACY;PRA;MLN 4;S100 calcium-binding protein A6 (calcyclin);calcyclin;growth factor-inducible protein 2A9;prolactin receptor-associated protein;protein S100-A6
Recombinant Proteins
- Human
- Mouse
- Rat
- Rabbit
- Rhesus macaque
- Chicken
- Insect Cells
- E.coli
- Mouse
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
- SUMO
Involved Pathway
S100A6 involved in several pathways and played different roles in them. We selected most pathways S100A6 participated on our site, such as Gastric cancer network 2,Prostaglandin Synthesis and Regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostaglandin Synthesis and Regulation | S100A10,ANXA6,CC10,ANXA3,ANXA5,ANXA2,ANXA4 |
| Gastric cancer network 2 | LBR,DSCC1,SNRPN,CHTF8,CEBPZ,RAD17,PLAC8,ATAD2,TOP2A,CHTF18 |
Protein Function
S100A6 has several biochemical functions, for example, S100 protein binding,calcium ion binding,calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A6 itself. We selected most functions S100A6 had, and list some proteins which have the same functions with S100A6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tropomyosin binding | PYCARD,TNNT2A,LMOD1,TNNT1,TMOD2,LMOD3,CALD1,NEBL,TMOD4,TMOD3 |
| calcium ion binding | MMP28,RASGRP1,ANXA11B,FSTL1A,SYT17,KCNIP1,MMP25,DOC2B,SPARCL1,CDH19 |
| S100 protein binding | S100A11,S100A1,S100B,EZR,DDX1,AHNAK,ANXA2,ANXA11,ATP2A2,AGER |
| calcium-dependent protein binding | SEC31A,CHP,SYT8,ALG2,CASQ2,MASP1,MYO1D,CALM2,ANXA3,ANXA1 |
| zinc ion binding | ZFAND2A,RABIF,ESR2B,BRAP,SAMHD1,ING1,MEP1A.2,NR3C2,RBM4B,TRIM59 |
| protein homodimerization activity | FZD1,MTMR2,LSM1,LGALS1,BHLHB9,USF2,NR2F2,RPE,PDCD6IP,HOMER2 |
| protein binding | PRKCZ,HINT2,PHF23,CDK5,NCK2,TMEM106B,C16orf53,THSD4,HK2,RABIF |
| ion transmembrane transporter activity | PLP2,LASP1,SFXN1,SFXN5B,SFXN5A,SFXN2,SFXN3,TRPV2,SFXN4,GJA1 |
Interacting Protein
S100A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A6.
KPNA2;PPID;FKBP4;PEX5;MDM2;S100B;TP53
Resources
Research Area
Renal MarkersInflammatory Mediators
Calcium-binding Proteins and Related Molecules
Glioma Biomarkers
Related Services
Related Products
References
- Meghnani, V; Wagh, A; et al. The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 57:54-62(2014).
- Jurewicz, E; Goral, A; et al. S100A6 is secreted from Wharton's jelly mesenchymal stem cells and interacts with integrin beta 1. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 55:298-303(2014).
