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Official Full Name S100 calcium binding protein B
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
Synonyms S100B; S100 calcium binding protein B; NEF; S100; S100-B; S100beta; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural);
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Bovine Brain
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human brain tissue
    • Human Cell
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • Fc
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human S100B-042H Recombinant Human S100B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human S100B-1116H Native Human S100B Protein Human brain tissue N/A
    Human S100B-227H Recombinant Human S100B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human S100B-2493H Recombinant Human S100B, GST-tagged E.coli GST
    Human S100B-2724H Recombinant Human S100 Calcium Binding Protein B, His-tagged E.coli His
    Human S100B-2858HCL Recombinant Human S100B cell lysate Human Cell N/A
    Human S100B-31009TH Recombinant Human S100B E.coli N/A
    Human S100B-31010TH Recombinant Human S100B, His-tagged E.coli His
    Human S100B-323H Recombinant Human S100B protein, His/MBP-tagged E.coli His/MBP
    Human S100B-34H Recombinant Human S100B protein E.coli N/A
    Human S100B-4571H Recombinant Human S100 Calcium Binding Protein B, GST-tagged Human GST
    Human S100B-68H Recombinant Human S100B, Fc tagged Human Cell Fc
    Human S100B-7016H Recombinant Human S100B protein, His-tagged E.coli His
    Mouse S100B-1418MCL Recombinant Mouse S100B cell lysate Human Cell N/A
    Mouse S100b-2570M Recombinant Mouse S100b protein, His-tagged E.coli His
    Mouse S100b-2571M Recombinant Mouse S100b, His-tagged E.coli His
    Mouse S100b-5673M Recombinant Mouse S100b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse S100b-7332M Recombinant Mouse S100b Protein, His-tagged E.coli His
    Mouse S100b-7412M Recombinant Mouse S100b, Fc tagged Human Cell Fc
    Rat S100B-5217R Recombinant Rat S100B Protein Mammalian Cell His
    Rat S100b-566R Recombinant Rat S100b protein, His-tagged E.coli His
    Rhesus Macaque S100B-4065R Recombinant Rhesus monkey S100B Protein, His-tagged Mammalian Cell His
    Rhesus S100B-544R Recombinant Rhesus S100B protein E.coli N/A
    Rhesus Macaque S100B-5482R Recombinant Rhesus Macaque S100 Calcium Binding Protein B E.coli N/A
    Bovine S100B-256B Native Bovine S-100 Protein Bovine Brain N/A
    Bovine S100B-257B Native Bovine S-100b Protein Bovine Brain N/A
    Rabbit S100B-2579R Recombinant Rabbit S100B protein, His-tagged E.coli His
    Chicken S100B-5623C Recombinant Chicken S100B Mammalian Cell His
    Zebrafish S100B-673Z Recombinant Zebrafish S100B Mammalian Cell His
    Cattle S100B-2578C Recombinant Cattle S100B protein, His & GST-tagged E.coli His/GST

    s100b involved in several pathways and played different roles in them. We selected most pathways s100b participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with s100b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling S100A12; DUSP7; APPA; ATF2; IRAK3; PELI1; TAB1; ALCAMB; DUSP6; AGER
    Advanced glycosylation endproduct receptor signaling SAA1; LGALS3; DDOST; S100B; AGER; ALCAMB; APPB; APPA; S100A12
    Cytosolic sensors of pathogen-associated DNA AGER; POLR3C; NLRP4E; ALCAMB; TRIM56; POLR3G; LRRFIP1; IFI16; POLR3GLA; TREX1
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production ALCAMB; S100B; APPA; CHST13; APPB; S100A12; SAA1; AGER; DHX9
    Innate Immune System DEFA1; LRRFIP1; DDOST; ABI1A; SIRPB1; CD180; CD300LB; LAT2; MAP3K8; KIR3DS1
    MyD88 cascade initiated on plasma membrane TNIP2; PELI1; S100A12; DHX9; ALCAMB; PELI3; S100B; CHST13; TLR10; DUSP3B
    MyD88 dependent cascade initiated on endosome CHST13; S100A12; ALCAMB; DHX9; S100B

    s100b has several biochemical functions, for example, RAGE receptor binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by s100b itself. We selected most functions s100b had, and list some proteins which have the same functions with s100b. You can find most of the proteins on our site.

    Function Related Protein
    RAGE receptor binding HMGB1; HMGB2; S100A7; S100P; S100A4; S100A13; S100B; FPR1; S100A9; S100A8
    S100 protein binding ATP2A2; S100B; ANXA2; AGER; FGF1A; DDX1; S100A6; AHNAK; FGF1; KCNK3
    calcium ion binding SPOCK2; EGFL8; PCDH2G3; CANT1; SYT2; SYT5A; PCDHGA6; PKD1L2; S100G; LRP2
    calcium-dependent protein binding S100A11; TNNT3; ANXA11; SNAP25; S100P; CCDC167; ALG2; FCN2; SLC9A1; TNNC1
    identical protein binding HOOK1; INS2; GNPNAT1; RGMB; BNIP3; PKD2L1; PYDC3; HTT; CLDN10; SH2B2
    protein binding KRTAP4-2; HPRT1; SIAH1; S100A14; MIA3; HARS2; GJB6; CBX5; PDCD6; TP53RK
    protein homodimerization activity PRPS1L1; IKZF2; USH1G; COMMD1; CD200; PTPRE; GSTM3; CEBPB; SLC9A7; CCBL1
    tau protein binding BIN1; APOE; SERPINB1A; HDAC6; S100B; FKBP4; PPP2R2A; AATF; SNCA; DYRK1A
    zinc ion binding GATA3; ZFAND4; RBM20; ZNF34; GATA1A; LHX4; ABLIM1A; LMX1BA; KAT6A; NR2E1

    s100b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with s100b here. Most of them are supplied by our site. Hope this information will be useful for your research of s100b.


    Davydov, DM; Lobanov, AV; et al. Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study. PHYSIOLOGY & BEHAVIOR 140:188-196(2015).
    Travis, TE; Ghassemi, P; et al. A Multimodal Assessment of Melanin and Melanocyte Activity in Abnormally Pigmented Hypertrophic Scar. JOURNAL OF BURN CARE & RESEARCH 36:77-86(2015).

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