• Official Full Name

    S100 calcium binding protein B

  • Overview

    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
  • Synonyms

    S100B; S100 calcium binding protein B; NEF; S100; S100-B; S100beta; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Zebrafish
  • Bovine Brain
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • Human brain tissue
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc|DDK
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human S100B-31009TH Recombinant Human S100B E.coli N/A
Human S100B-4571H Recombinant Human S100 Calcium Binding Protein B, GST-tagged Human GST
Human S100B-68H Active Recombinant Human S100B protein(Ser2-Glu92), hFc-tagged HEK293 N-hFc Ser2-Glu92
Human S100B-2493H Recombinant Human S100B, GST-tagged E.coli GST 1-92aa
Human S100B-323H Recombinant Human S100B protein, His/MBP-tagged E.coli His/MBP
Human S100B-2724H Recombinant Human S100 Calcium Binding Protein B, His-tagged E.coli His
Human S100B-7016H Recombinant Human S100B protein, His-tagged E.coli His Met1-Glu92
Human S100B-31010TH Active Recombinant Human S100B protein(Ser2-Glu92), His-tagged E.coli N-His Ser2-Glu92
Human S100B-34H Recombinant Human S100B protein E.coli N/A
Human S100B-2858HCL Recombinant Human S100B cell lysate Human Cell N/A
Human S100B-0052H Recombinant Human S100B Protein HEK293 cells
Human S100B-2542H Recombinant Human S100B protein(11-80 aa), C-His-tagged E.coli C-His 11-80 aa
Human S100B-374HFL Recombinant Full Length Human S100B Protein, C-Flag-tagged Mammalian cells Flag
Human S100B-3633H Recombinant Human S100B protein, GST-tagged E.coli GST 50 - 92 aa
Human S100B-1945H Recombinant Human S100B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human S100B-64H Recombinant Human S100B Protein, His-tagged E.coli His Met1-Glu92
Human S100B-227H Recombinant Human S100B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human S100B-1116H Native Human S100B Protein Human brain tissue N/A
Human S100B-1945H-B Recombinant Human S100B Protein Pre-coupled Magnetic Beads HEK293
Human S100B-042H Recombinant Human S100B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse S100b-2571M Recombinant Mouse S100b, His-tagged E.coli His
Mouse S100b-2570M Recombinant Mouse S100b protein, His-tagged E.coli His Met1-Glu92
Mouse S100b-7412M Recombinant Mouse S100b protein(Ser2-Glu92), hFc-tagged HEK293 N-hFc Ser2-Glu92
Mouse S100B-1418MCL Recombinant Mouse S100B cell lysate Human Cell N/A
Mouse S100b-7332M Recombinant Mouse S100b Protein, His-tagged E.coli His 1-92
Mouse S100b-5673M Recombinant Mouse S100b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse S100B-65M Recombinant Mouse S101B Protein, His-tagged E.coli His
Rat S100B-5217R Recombinant Rat S100B Protein Mammalian Cell His
Rat S100b-566R Recombinant Rat S100b protein, His-tagged E.coli His Met1~Glu92
Rat S100B-4876R-B Recombinant Rat S100B Protein Pre-coupled Magnetic Beads HEK293
Rat S100B-4876R Recombinant Rat S100B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit S100B-2579R Recombinant Rabbit S100B protein, His-tagged E.coli His Met1~Glu92 (Accession # Q6YNR6)
Bovine S100B-256B Native Bovine S-100 Protein Bovine Brain N/A
Bovine S100B-257B Native Bovine S-100b Protein Bovine Brain N/A
Bovine S100B-3543B Recombinant Bovine S100B protein, His-Avi-tagged E.coli N-His-Avi 2-92aa
Cattle S100B-2578C Recombinant Cattle S100B protein, His & GST-tagged E.coli His/GST Met1~Glu92 (Accession # P02638)
Rhesus S100B-544R Recombinant Rhesus S100B protein E.coli N/A 91
Rhesus Macaque S100B-5482R Recombinant Rhesus Macaque S100 Calcium Binding Protein B E.coli N/A
Rhesus Macaque S100B-4065R Recombinant Rhesus monkey S100B Protein, His-tagged Mammalian Cell His
Rhesus Macaque S100B-3882R-B Recombinant Rhesus Macaque S100B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque S100B-3882R Recombinant Rhesus Macaque S100B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish S100B-673Z Recombinant Zebrafish S100B Mammalian Cell His
Chicken S100B-5623C Recombinant Chicken S100B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

S100B involved in several pathways and played different roles in them. We selected most pathways S100B participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Advanced glycosylation endproduct receptor signalingAGER;S100A12;ALCAMB;DDOST;SAA1;LGALS3;APPB;APPA;S100B
Cytosolic sensors of pathogen-associated DNAS100A12;IFI16;AGER;NLRP4;S100B;ALCAMB;TICAM1;POLR3GLA;MB21D1
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionSAA1;S100A12;ALCAMB;APPB;APPA;CHST13;AGER;S100B;DHX9
MyD88 cascade initiated on plasma membraneS100A12;TNIP2;DHX9;CHST13;PELI3;ALCAMB;AGER;PELI2;S100B
MyD88 dependent cascade initiated on endosomeALCAMB;DHX9;S100B;CHST13;S100A12

S100B has several biochemical functions, for example, RAGE receptor binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100B itself. We selected most functions S100B had, and list some proteins which have the same functions with S100B. You can find most of the proteins on our site.

Function Related Protein
RAGE receptor bindingS100A9;S100A8;S100A7;S100P;S100B;HMGB2;FPR1;HMGB1;S100A12
S100 protein bindingFGF1A;S100A6;KCNK3;S100A11;ATP2A2;S100B;AGER;AHNAK;FGF1
calcium ion bindingRAB11FIP4A;TGM3;EFHC1;PVALB3;PCDH2G9;PCDHB10;S100A7A;ATP2C1;PCDH1G29
calcium-dependent protein bindingPDCD6IP;CALM2;SEC31A;CHP;CASQ2;TNNC1;DDX5;STMN2;MYO1D
identical protein bindingCD28;NDE1;RGMB;GRASP;MRAP2;CLDN23;RILPL2;STK4;CSK
protein bindingTRPV4;TREML2;EPHA7;PLN;MAD2L2;ZNF259;SNRPB;HMGB1;CT45A3
protein homodimerization activityATPIF1A;RENBP;PRDX4;GDF6;S100A16;IL6ST;BOKB;ID1;FIGF
zinc ion bindingMMP15;RNF144A;RNF11;APOBEC1;PJA1;FBXO40;OAS1;MMP14A;CAR7

S100B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100B here. Most of them are supplied by our site. Hope this information will be useful for your research of S100B.


Research Area

Related articles

Davydov, DM; Lobanov, AV; et al. Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study. PHYSIOLOGY & BEHAVIOR 140:188-196(2015).
Travis, TE; Ghassemi, P; et al. A Multimodal Assessment of Melanin and Melanocyte Activity in Abnormally Pigmented Hypertrophic Scar. JOURNAL OF BURN CARE & RESEARCH 36:77-86(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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    One major advantage of S100B protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.


      The S100B protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.


        The manufacturer of S100B protein plays a crucial role in supporting my research efforts.

        Q&As (5)

        Ask a question
        How does S100B help in the diagnosis of traumatic brain injury (TBI)? 01/29/2023

        Elevated S100B levels in the blood can indicate TBI, and its measurement can aid in TBI diagnosis and severity assessment.

        What conditions can S100B be used to diagnose? 01/11/2023

        S100B can be used to diagnose brain injuries, such as traumatic brain injury and stroke.

        How is S100B measured in clinical settings? 02/24/2020

        S100B levels are typically measured through a blood test.

        What precautions should be taken when interpreting S100B results? 02/02/2017

        Results should be interpreted in the context of the patient's clinical history and other diagnostic tests.

        How is S100B used in the context of neurodegenerative diseases? 02/07/2016

        S100B may help in monitoring disease progression and severity in conditions like Alzheimer's disease.

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