s100b
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  • Official Full Name
  • S100 calcium binding protein B
  • Background
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
  • Synonyms
  • S100B; S100 calcium binding protein B; NEF; S100; S100-B; S100beta; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural);
Cat.#:S100B-227HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human S100B Protein, MYC/DDK-tagged
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Cat.#:S100B-5482RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque S100 Calcium Binding Protein B
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Cat.#:S100B-2493HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100B, GST-tagged
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Cat.#:S100B-31009THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100B
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Cat.#:S100B-31010THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100B, His-tagged
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Cat.#:S100B-323HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100B protein, His/MBP-tagged
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Cat.#:S100B-34HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100B protein
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Cat.#:S100B-4571HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100 Calcium Binding Protein B, GST-tagged
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Cat.#:S100B-68HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human S100B, Fc tagged
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Cat.#:S100B-7016HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100B, His tagged
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Cat.#:S100b-2570MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse S100b protein, His-tagged
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Cat.#:S100b-2571MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse S100b, His-tagged
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Cat.#:S100b-7412MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse S100b, Fc tagged
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Cat.#:S100B-5217RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat S100B Protein
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Cat.#:S100b-566RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat S100b protein, His-tagged
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Cat.#:S100B-4065RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey S100B Protein, His-tagged
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Cat.#:S100B-544RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey S100B
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Cat.#:S100B-2579RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit S100B protein, His-tagged
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Cat.#:S100B-5623CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken S100B
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Cat.#:S100B-673ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish S100B
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Cat.#:S100B-2578CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle S100B protein, His & GST-tagged
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Cat.#:S100B-2724HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100 Calcium Binding Protein B, His-tagged
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Cat.#:S100B-1116HTag:
Source (Host):Human brain tissueSpecies:Human
Product nameNative Human S100B Protein
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Cat.#:S100B-256BTag:
Source (Host):Species:Bovine
Product nameNative Bovine S-100 Protein
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Cat.#:S100B-257BTag:
Source (Host):Species:Bovine
Product nameNative Bovine S-100b Protein
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Cat.#:S100B-2858HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human S100B cell lysate
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Cat.#:S100B-1418MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse S100B cell lysate
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Involved Pathway

S100B involved in several pathways and played different roles in them. We selected most pathways S100B participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
PELI3; DHX9; DUSP6; S100B; IRAK3; DUSP3B; TIRAP; ALCAMB; ATF2; AGER
Advanced glycosylation endproduct receptor signaling
APPA; AGER; APPB; DDOST; LGALS3; S100B; SAA1; ALCAMB; S100A12
Cytosolic sensors of pathogen-associated DNA
APPA; DHX9; NLRP4C; TRIM56; POLR3F; POLR3H; S100A12; CRCP; NLRP4; POLR3C
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
DHX9; APPA; APPB; CHST13; S100B; SAA1; S100A12; ALCAMB; AGER
Immune System
DEFB106A; IFI35; TRIM69; ASB6; S100B; LRR1; GRAP2A; SIGLEC15; TRIM46; KIF3B
Innate Immune System
RNF216; MGC174857; BTR06; DEFA6; PELI3; GZMM; ART1; CRP; DEFA5; CR1
MyD88 cascade initiated on plasma membrane
ALCAMB; TLR10; S100B; S100A12; AGER; DHX9; PELI1; TNIP2; DUSP3B; CHST13
MyD88 dependent cascade initiated on endosome
S100A12; DHX9; ALCAMB; CHST13; S100B

Protein Function

S100B has several biochemical functions, for example, RAGE receptor binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100B itself. We selected most functions S100B had, and list some proteins which have the same functions with S100B. You can find most of the proteins on our site.
Function
Related Protein
Function RAGE receptor binding
Related Protein S100A9; S100P; S100A12; FPR1; S100A13; S100A7; S100A8; S100B; HMGB1; S100A4
Function S100 protein binding
Related Protein DDX1; AGER; EZR; ATP2A2; AHNAK; FGF1A; S100A1; KCNK3; ANXA11; FGF1
Function calcium ion binding
Related Protein DSG2; S100T; PRRG1; THBD; CAMKK2; RPH3AL; PGS1; ITSN2; ANXA11B; PLA2G10
Function calcium-dependent protein binding
Related Protein NELF; SYT1; KCNIP3; C9orf9; KOP; MASP2; PDCD6IP; RAC3; S100PBP; STX1A
Function identical protein binding
Related Protein TTC32; PSME3; SNX33; PYCARD; CLDN17; MUL1A; APLP1; RASSF1; HOOK1; SOD1
Function protein binding
Related Protein C11orf68; FLG; RAB14; RBM12B; GLRB; PRAP1; ELF1; FKBP4; SOD1; NUP98
Function protein homodimerization activity
Related Protein CBX5; EVLA; CAV2; SDCBP2; TFAP4; NOG; ZBTB1; PON3; CHEK2; VPS24
Function tau protein binding
Related Protein SERPINB1A; FKBP4; APOE; BIN1; HDAC6; SNCA; S100B; PPP2R2A; AATF; DYRK1A
Function zinc ion binding
Related Protein TRAF4B; MMP26; USP5; S100A12; NSMCE1; CHD4A; CA6; ING1; LONRF1L; TRIM8A

Interacting Protein

S100B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100B here. Most of them are supplied by our site. Hope this information will be useful for your research of S100B.
S100A1

S100B Related Articles

Davydov, DM; Lobanov, AV; et al. Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study. PHYSIOLOGY & BEHAVIOR 140:188-196(2015).
Travis, TE; Ghassemi, P; et al. A Multimodal Assessment of Melanin and Melanocyte Activity in Abnormally Pigmented Hypertrophic Scar. JOURNAL OF BURN CARE & RESEARCH 36:77-86(2015).