S100B Protein


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Official Full Name S100 calcium binding protein B
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
Synonyms S100B; S100 calcium binding protein B; NEF; S100; S100-B; S100beta; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural);
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Bovine Brain
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Human
    • Human brain tissue
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • C-Myc/DDK
    • Fc
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse S100b-2570M Recombinant Mouse S100b protein, His-tagged E.coli His Inquiry
    Human S100B-2493H Recombinant Human S100B, GST-tagged E.coli GST Inquiry
    Human S100B-2724H Recombinant Human S100 Calcium Binding Protein B, His-tagged E.coli His
    Human S100B-31009TH Recombinant Human S100B E.coli N/A Inquiry
    Human S100B-31010TH Recombinant Human S100B, His-tagged E.coli His Inquiry
    Human S100B-323H Recombinant Human S100B protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human S100B-34H Recombinant Human S100B protein E.coli N/A Inquiry
    Human S100B-4571H Recombinant Human S100 Calcium Binding Protein B, GST-tagged Human GST Inquiry
    Human S100B-68H Recombinant Human S100B, Fc tagged Human Cell Fc
    Human S100B-7016H Recombinant Human S100B protein, His-tagged E.coli His Inquiry
    Mouse S100b-2571M Recombinant Mouse S100b, His-tagged E.coli His Inquiry
    Mouse S100b-7412M Recombinant Mouse S100b, Fc tagged Human Cell Fc Inquiry
    Rat S100B-5217R Recombinant Rat S100B Protein Mammalian Cell His Inquiry
    Rat S100b-566R Recombinant Rat S100b protein, His-tagged E.coli His Inquiry
    Rhesus Macaque S100B-4065R Recombinant Rhesus monkey S100B Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus S100B-544R Recombinant Rhesus S100B protein E.coli N/A Inquiry
    Rhesus Macaque S100B-5482R Recombinant Rhesus Macaque S100 Calcium Binding Protein B E.coli N/A Inquiry
    Rabbit S100B-2579R Recombinant Rabbit S100B protein, His-tagged E.coli His Inquiry
    Chicken S100B-5623C Recombinant Chicken S100B Mammalian Cell His Inquiry
    Zebrafish S100B-673Z Recombinant Zebrafish S100B Mammalian Cell His Inquiry
    Cattle S100B-2578C Recombinant Cattle S100B protein, His & GST-tagged E.coli His/GST Inquiry
    Human S100B-2858HCL Recombinant Human S100B cell lysate Human Cell N/A Inquiry
    Mouse S100B-1418MCL Recombinant Mouse S100B cell lysate Human Cell N/A Inquiry
    Human S100B-0052H Recombinant Human S100B Protein HEK293 cells Inquiry
    Human S100B-1945H Recombinant Human S100B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human S100B-3633H Recombinant Human S100B protein, GST-tagged E.coli GST Inquiry
    Human S100B-374HFL Recombinant Full Length Human S100B Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Rhesus Macaque S100B-3882R Recombinant Rhesus Macaque S100B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rat S100B-4876R Recombinant Rat S100B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human S100B-64H Recombinant Human S100B Protein, His-tagged E.coli His Inquiry
    Mouse S100B-65M Recombinant Mouse S101B Protein, His-tagged E.coli His Inquiry
    Human S100B-042H Recombinant Human S100B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK Inquiry
    Human S100B-227H Recombinant Human S100B Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Mouse S100b-5673M Recombinant Mouse S100b Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Mouse S100b-7332M Recombinant Mouse S100b Protein, His-tagged E.coli His Inquiry
    Bovine S100B-256B Native Bovine S-100 Protein Bovine Brain N/A Inquiry
    Bovine S100B-257B Native Bovine S-100b Protein Bovine Brain N/A Inquiry
    Human S100B-1116H Native Human S100B Protein Human brain tissue N/A Inquiry

    S100B involved in several pathways and played different roles in them. We selected most pathways S100B participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling CHUK; ALCAMB; NOD1; JUN; TIRAP; IRAK3; DUSP3B; RIPK3; APPB; AGER
    Advanced glycosylation endproduct receptor signaling ALCAMB; S100A12; LGALS3; APPB; DDOST; AGER; SAA1; S100B; APPA
    Cytosolic sensors of pathogen-associated DNA MB21D1; DDX41; POLR3H; S100B; NLRP4; NLRP4E; SAA1; ALCAMB; CHST13; S100A12
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production S100B; APPA; CHST13; AGER; SAA1; DHX9; APPB; ALCAMB; S100A12
    Immune System ASB8; KPNA4; ALCAMB; ATP6V1G3; NA; CFD; TRIM45; DYNC1I1; TIRAP; GBP6
    Innate Immune System HERC5; BTR30; BFB; LGALS3; DUSP3B; IFI16; FCN1; CFHL2; DHX9; PANX1
    MyD88 cascade initiated on plasma membrane DHX9; S100A12; ALCAMB; CHST13; PELI2; PELI1; TLR10; TNIP2; DUSP3B; PELI3
    MyD88 dependent cascade initiated on endosome CHST13; DHX9; S100A12; S100B; ALCAMB

    S100B has several biochemical functions, for example, RAGE receptor binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100B itself. We selected most functions S100B had, and list some proteins which have the same functions with S100B. You can find most of the proteins on our site.

    Function Related Protein
    RAGE receptor binding S100A8; S100A13; S100A9; S100A4; HMGB2; HMGB1; S100B; S100A12; S100P; S100A7
    S100 protein binding DDX1; FGF1; AHNAK; ATP2A2; S100A11; S100B; ANXA2; S100A1; ANXA11; AGER
    calcium ion binding F9A; EYS; CDH8; RASGRP3; S100A3; PVALB9; CRP; NID1; MMP8; PCDHB7
    calcium-dependent protein binding STMN2; S100B; STX1A; S100A6; DMBT1; S100A11; S100PBP; SEC31A; PLSCR3; ANXA4
    identical protein binding COL7A1; TRAF6; APOE; PRMT8; MIEF1; BCL2; VIL1; TPRG1L; CDC42; RUVBL2
    protein binding SHISA5; TXLNG; KIF1B; KEAP1; ACVR2B; YTHDC1; DCLRE1C; PHAX; MAL; UTF1
    protein homodimerization activity UGT1A4; APOA1BP; NR4A2; PTPRE; ZHX3; RQCD1; CCBL1; PLEK; EVLA; RPL7
    tau protein binding BIN1; HDAC6; S100B; SERPINB1A; SNCA; PPP2R2A; APOE; AATF; DYRK1A; FKBP4
    zinc ion binding HLTF; MMP9; CBL; MEX3B; LTA4H; MMP19; MORC2B; GFI1AA; TRIM72; CPDB

    S100B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100B here. Most of them are supplied by our site. Hope this information will be useful for your research of S100B.


    Davydov, DM; Lobanov, AV; et al. Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study. PHYSIOLOGY & BEHAVIOR 140:188-196(2015).
    Travis, TE; Ghassemi, P; et al. A Multimodal Assessment of Melanin and Melanocyte Activity in Abnormally Pigmented Hypertrophic Scar. JOURNAL OF BURN CARE & RESEARCH 36:77-86(2015).

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