SFN

  • Official Full Name

    SFN stratifin

  • Overview

    Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.
  • Synonyms

    SFN; stratifin; 14-3-3 protein sigma; 14 3 3 sigma; YWHAS; 14-3-3 sigma; epithelial cell marker protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SFN-1421H Recombinant Human Stratifin, GST-tagged E.coli GST
Human SFN-3857H Recombinant Human SFN protein, GST-tagged E.coli GST Met1-Ser248
Human SFN-149H Recombinant Human SFN Protein, His-tagged Insect Cell His
Human SFN-26013TH Recombinant Human SFN E.coli N/A
Human SFN-26015TH Recombinant Human SFN, His-tagged His
Human SFN-5121H Recombinant Human Stratifin Human N/A
Human SFN-855H Recombinant Human SFN protein E.coli N/A Met1-Ser248
Human SFN-008H Recombinant Human SFN Protein, His-tagged E.coli His
Human SFN-1912HCL Recombinant Human SFN 293 Cell Lysate HEK293 N/A
Human SFN-1991H-B Recombinant Human SFN Protein Pre-coupled Magnetic Beads HEK293
Human SFN-4511H Recombinant Human SFN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SFN-1991H Recombinant Human SFN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SFN-4643H Recombinant Human SFN protein(1-248aa), His-GST&Myc-tagged E. coli N-His-GST&C-Myc 1-248aa
Human SFN-5824H Recombinant Human SFN Protein (Met1-Ser248), N-His tagged E.coli N-His Met1-Ser248
Human SFN-942HFL Recombinant Full Length Human SFN Protein, C-Flag-tagged Mammalian cells Flag
Human SFN-4644H Recombinant Human SFN protein(1-248aa), His&Myc-tagged E. coli N-His&C-Myc 1-248aa
Mouse Sfn-4045M Recombinant Mouse Sfn protein(Met1-Ser248) E.coli N/A Met1-Ser248
Mouse SFN-15005M Recombinant Mouse SFN Protein Mammalian Cell His
Mouse SFN-8081M Recombinant Mouse SFN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sfn-5813M Recombinant Mouse Sfn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SFN-8081M-B Recombinant Mouse SFN Protein Pre-coupled Magnetic Beads HEK293
Mouse Sfn-697M Recombinant Mouse Sfn Protein, His-tagged E.coli His Met1~Ser249
Rhesus Macaque SFN-4172R Recombinant Rhesus monkey SFN Protein, His-tagged Mammalian Cell His
Rhesus Macaque SFN-3989R Recombinant Rhesus Macaque SFN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SFN-3989R-B Recombinant Rhesus Macaque SFN Protein Pre-coupled Magnetic Beads HEK293
Chicken SFN-5538C Recombinant Chicken SFN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SFN involved in several pathways and played different roles in them. We selected most pathways SFN participated on our site, such as Cell cycle, p signaling pathway, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleTGFB2;TMPO;ATM;TUBG2;CDC25A;CSNK2A1;GADD45BA;CLASP1A;NDC80
p signaling pathwayTP73;SIAH1A;CDK1;GTSE1;SERPINE1;RFWD2;CCNB2;CASP9;PPM1DA
Aldosterone-regulated sodium reabsorptionATP1A1;SCNN1B;IRS1;PIK3R5;INSR;PIK3R1;PIK3CB;ALPHA-ENAC;NR3C2

SFN has several biochemical functions, for example, phosphoprotein binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SFN itself. We selected most functions SFN had, and list some proteins which have the same functions with SFN. You can find most of the proteins on our site.

Function Related Protein
phosphoprotein bindingSFN;CSNK1D;MID1;SRC;TOX3;CACNB2;SERPINB1A;TBK1;LYN
protein bindingANKZF1;CHERP;ARNTL;IMPA2;TSSK1;ECE2;BST2;CCDC135;ACAD9
protein domain specific bindingRAP2B;CRB3;TFDP2;HIST1H4B;OCLN;ATP1A1;PPP3R1;ARRB2;TWIST2
protein kinase C inhibitor activitySFN;HSPB1;YWHAG
protein kinase bindingDNM1;GCSAM;SHC3;DNAJC3;PRKCZ;TP73;VDAC1;HDAC4;PRKAG3

SFN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFN here. Most of them are supplied by our site. Hope this information will be useful for your research of SFN.

EGFR; BAD; RFWD2; HDAC4

Research Area

Related articles

Wu, CC; Chuang, HY; et al. Inhibition of Epstein-Barr Virus Reactivation in Nasopharyngeal Carcinoma Cells by Dietary Sulforaphane. MOLECULAR CARCINOGENESIS 52:946-958(2013).
Sene, D; Cacoub, P; et al. Sjogren Syndrome-Associated Small Fiber Neuropathy Characterization From a Prospective Series of 40 Cases. MEDICINE 92:E10-E18(2013).
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