Recombinant Human Stratifin

Cat.No. : SFN-5121H
Product Overview : Recombinant human SFN was expressed in E. coli and purified by using conventional chromatography techniques.
  • Specification
  • Gene Information
  • Related Products
  • Download
Cat. No. : SFN-5121H
Description : 14-3-3 sigma, also known as Stratifin (SFN), belongs to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 50mM NaCl and 10% glycerol.
Purity : > 95% by SDS - PAGE
Sequence : 1-248 amino acids: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKD
Molecular Mass : 27.7 kDa (248aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
FACS:
Gene Name : SFN stratifin [ Homo sapiens ]
Official Symbol : SFN
Synonyms : SFN; stratifin; YWHAS; 14-3-3 protein sigma; 14-3-3 sigma; OTTHUMP00000004242; epithelial cell marker protein 1; HME1
Gene ID : 2810
mRNA Refseq : NM_006142
Protein Refseq : NP_006133
MIM : 601290
UniProt ID : P31947
Chromosome Location : 1p36.11
Pathway : Aldosterone-regulated sodium reabsorption; Alpha6-Beta4 Integrin Signaling Pathway; Calcium Regulation in the Cardiac Cell; Cell cycle; Class I PI3K signaling events mediated by Akt; Direct p53 effectors; ErbB1 downstream signaling; FoxO family signaling; Glucocorticoid receptor regulatory network; Insulin-mediated glucose transport; LKB1 signaling events; Myometrial Relaxation and Contraction Pathways; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Role of Calcineurin-dependent NFAT signaling in lymphocytes; Trk receptor signaling mediated by PI3K and PLC-gamma; a6b1 and a6b4 Integrin signaling; mTOR signaling pathway
Function : protein binding; protein domain specific binding; protein kinase C inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SFN Products

Required fields are marked with *

My Review for All SFN Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /
  • Service lnquiry:

Stay Updated on the Latest Bioscience Trends