Recombinant Human SFN Protein, His-tagged

Cat.No. : SFN-149H
Product Overview : Recombinant Human SFN fused with His tag at N-terminal was expressed in Insect cells.
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Description : 14-3-3 sigma or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents. The induction of 14-3-3 sigma is mediated by a p53 responsive element. Exogenous introduction of 14-3-3 sigma into cycling cells results in a G2 cell cycle arrest. Knockout of 14-3-3 sigma in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3sigma -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3sigma-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3 sigma plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death.
Source : Insect cells
Species : Human
Tag : His
Form : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol
Molecular Mass : 30 kDa
Purity : > 95%
Applications : Western Blot
Stability : 1 year at -70 centigrade from date of shipment.
Storage : Store product at –70centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.2 ug/ml
Gene Name : SFN stratifin [ Homo sapiens ]
Official Symbol : SFN
Synonyms : SFN; stratifin; 14-3-3 protein sigma; 14 3 3 sigma; YWHAS; 14-3-3 sigma; epithelial cell marker protein 1;
Gene ID : 2810
mRNA Refseq : NM_006142
Protein Refseq : NP_006133
MIM : 601290
UniProt ID : P31947

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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