Recombinant Human SFN Protein, His-tagged
Cat.No. : | SFN-149H |
Product Overview : | Recombinant Human SFN fused with His tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | 14-3-3 sigma or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents. The induction of 14-3-3 sigma is mediated by a p53 responsive element. Exogenous introduction of 14-3-3 sigma into cycling cells results in a G2 cell cycle arrest. Knockout of 14-3-3 sigma in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3sigma -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3sigma-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3 sigma plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol |
Molecular Mass : | 30 kDa |
Purity : | > 95% |
Applications : | Western Blot |
Stability : | 1 year at -70 centigrade from date of shipment. |
Storage : | Store product at –70centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.2 ug/ml |
Gene Name : | SFN stratifin [ Homo sapiens ] |
Official Symbol : | SFN |
Synonyms : | SFN; stratifin; 14-3-3 protein sigma; 14 3 3 sigma; YWHAS; 14-3-3 sigma; epithelial cell marker protein 1; |
Gene ID : | 2810 |
mRNA Refseq : | NM_006142 |
Protein Refseq : | NP_006133 |
MIM : | 601290 |
UniProt ID : | P31947 |
Products Types
◆ Recombinant Protein | ||
SFN-1991H | Recombinant Human SFN Protein, His (Fc)-Avi-tagged | +Inquiry |
Sfn-697M | Recombinant Mouse Sfn Protein, His-tagged | +Inquiry |
Sfn-5813M | Recombinant Mouse Sfn Protein, Myc/DDK-tagged | +Inquiry |
SFN-8081M | Recombinant Mouse SFN Protein, His (Fc)-Avi-tagged | +Inquiry |
Sfn-4045M | Recombinant Mouse Sfn protein(Met1-Ser248) | +Inquiry |
◆ Lysates | ||
SFN-1912HCL | Recombinant Human SFN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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