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SIGLEC8

  • Official Full Name

    sialic acid binding Ig-like lectin 8

  • Overview

    Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1;transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of;the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic;tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif;homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an;association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 (PubMed;11095983)).
  • Synonyms

    SIGLEC8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; MGC59785; SAF2; SIGLEC 8; SIGLEC8L; SAF-2; CDw329; sialoadhesin family member 2; SIGLEC-8;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • C
  • Fc
  • Flag
  • hFc
  • His
  • His (Fc)
  • Avi
  • His|GST
  • mFc
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIGLEC8-1799H Recombinant Human SIGLEC8 protein, His & GST-tagged E.coli His/GST Gly70~Ser336 (Accession # Q9NYZ4)
Human SIGLEC8-2670H Recombinant Human SIGLEC8, His-tagged E.coli His 1-360aa
Human SIGLEC8-1776HFL Recombinant Full Length Human SIGLEC8 Protein, C-Flag-tagged Mammalian cells Flag
Human SIGLEC8-772H Recombinant Human SIGLEC8 protein, His-tagged HEK293 His Met17-Ala363
Human SIGLEC8-679H Recombinant Human SIGLEC8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SIGLEC8-1014H Recombinant Human SIGLEC8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SIGLEC8-143H-B Recombinant Human SIGLEC8 Protein Pre-coupled Magnetic Beads HEK293
Human SIGLEC8-197HB Recombinant Human SIGLEC8 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Met17-Ala363.
Human SIGLEC8-6584H Active Recombinant Human SIGLEC8 Protein, Fc-tagged Mammalian cells Fc
Human SIGLEC8-0693H Recombinant Human SIGLEC8 protein, Fc-tagged HEK293 Fc Met17-Ala363
Human SIGLEC8-137H Recombinant Human SIGLEC8 protein, His-Avi-tagged HEK293 His-Avi It contains Met17-Ala363.
Human SIGLEC8-139H Recombinant Human SIGLEC8(Met17-Ala363) Protein, C-mFc-tagged HEK293 mFc
Human SIGLEC8-138H Recombinant Human SIGLEC8 protein, hFc-tagged HEK293 hFc It contains Met17-Ala363.
Human SIGLEC8-143H Recombinant Human SIGLEC8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SIGLEC8-5809H Recombinant Human SIGLEC8 Protein (Met1-Ala363), C-Fc tagged Mammalian cells C-Fc Met1-Ala363
Mouse SIGLEC8-139M Recombinant Mouse SIGLEC8(Asp18-Thr437) Protein, C-6*His-tagged HEK293 His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIGLEC8 Related Research Area

SIGLEC8 involved in several pathways and played different roles in them. We selected most pathways SIGLEC8 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemDNM2;ARIH2;TRAF7;ARF1;ITK;UBR1;KLRF1;UBA5;SIGLEC10
Immune SystemMASP2;RNF19B;DUSP3;RIPK3;BTR30;CLEC5A;DYNC1I1;CRCP;CD300LB
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellCD160;CD200R3;SIGLEC5;SIGLEC8;AMICA1;CLEC2G;LILRB3;CD226;CLEC2D

SIGLEC8 has several biochemical functions, for example, carbohydrate binding, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC8 itself. We selected most functions SIGLEC8 had, and list some proteins which have the same functions with SIGLEC8. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingFCER2;Cd24a;CHIA;SELL;CLEC9A;KLRC1;LGALS4;PRPS1;GALNT4
protein bindingPRKCD;PRKDC;CRYBA2;SLC25A10;TERF1;NFIL3;MLF1IP;MAPRE1;BMPR1AA
transmembrane signaling receptor activityDNER;TLR3;SPN;KLRF1;FCGR2C;PTH1RB;CD5;OR103-4;FCAMR

SIGLEC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC8.

TFF1

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