SORT1

  • Official Full Name

    sortilin 1

  • Overview

    This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008]
  • Synonyms

    SORT1; sortilin 1; NT3; Gp95; LDLCQ6; sortilin; NTR3; glycoprotein 95; 100 kDa NT receptor; neurotensin receptor 3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • GST
  • His
  • Avi
  • Fc
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SORT1-15H Active Recombinant Human Neurotensin Receptor 3/Sortilin Mammalian cells His
Human SORT1-8143H Recombinant Human SORT1 protein, His & GST-tagged E.coli His&GST Trp50~Asp320
Human SORT1-2879H Recombinant Human SORT1, GST-tagged E.coli GST C-term-351aa
Human SORT1-29618TH Recombinant Human SORT1 protein, GST-tagged Wheat Germ GST 203-299
Human SORT1-6212H Recombinant Human SORT1 Protein (Trp50-Asp320), N-GST tagged E.coli GST Trp50-Asp320
Human SORT1-1932H Recombinant Human SORT1 protein, His-tagged HEK293 His Ser 78 - Asn 755
Human SORT1-0722H Recombinant Human SORT1 protein, His-tagged HEK293 His Ser78-Asn755
Human SORT1-4105H Recombinant Human SORT1 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human SORT1-4105H-B Recombinant Human SORT1 Protein Pre-coupled Magnetic Beads HEK293
Human SORT1-0721H Recombinant Human SORT1 protein, His-Avi-tagged, Biotinylated HEK293 His&Avi Ser78-Asn755
Mouse Sort1-430M Recombinant Mouse Sort1 protein, His-tagged HEK293 His
Rat SORT1-5672R Recombinant Rat SORT1 Protein Mammalian Cell His
Rat Sort1-1374R Recombinant Rat Sort1 Protein, His-SUMO-tagged E.coli His&SUMO 610-754
Rat SORT1-1527R Recombinant Rat SORT1 Protein (610-754 aa), His-tagged Yeast His 610-754 aa
Rat Sort1-3517R Recombinant Rat Sort1 protein, His-tagged E.coli His 610-754aa
Rat SORT1-5331R Recombinant Rat SORT1 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat SORT1-5331R-B Recombinant Rat SORT1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SORT1 involved in several pathways and played different roles in them. We selected most pathways SORT1 participated on our site, such as Lysosome, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SORT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeCD164;PPT2;ATP6V0CB;AGA;NAGLU;Ctsl;SLC11A1;DNASE2A;SLC17A5
Neurotrophin signaling pathwayMAP3K1;MAPK11;RIPK2;PLCG2;NGF;TP73;SH2B2;SH2B1;TRP53

SORT1 has several biochemical functions, for example, enzyme binding, nerve growth factor binding, nerve growth factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SORT1 itself. We selected most functions SORT1 had, and list some proteins which have the same functions with SORT1. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingNOS1;TH;GSTM4;PRMT1;NPM2;CYP2C19;RPS2;HIST1H2AI;APOA5
nerve growth factor bindingNTRK1;NGFR;SORT1;NGFRB;PCSK6;FURIN
nerve growth factor receptor activitySORT1;NTRK1
neurotensin receptor activity, non-G-protein coupled
protein bindingPPP1R15A;FAS;TSEN54;EMP2;RBM42;RAD51C;UTP14A;RALGAPA1;NFATC3

SORT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORT1.

GGA2; GGA1; LPL; CDK2; NGF

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