Recombinant Rat SORT1 Protein (610-754 aa), His-tagged

• Cat.No.: SORT1-1527R
• Product Overview: Recombinant Rat SORT1 Protein (610-754 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the Extracellular domain matrix during osteogenic differentiation by scavenging Extracellular domain LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
• Source: Yeast
• Species: Rat
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 18.5 kDa
• Protein length: 610-754 aa
• AA Sequence: CEENDYTTWLAHSTDPGDYKDGCIL GYKEQFLRLRKSSVCQNGRDYVVAK QPSICPCSLEDFLCDFGYFRPENAS ECVEQPELKGHELEFCLYGKEEHLT TNGYRKIPGDRCQGGMNPAREVKDL KKKCTSNFLNPKKQNSKSSS
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Sort1 sortilin 1 [ Rattus norvegicus ]
• Official Symbol: SORT1
• Synonyms: SORT1; sortilin 1; sortilin; NTR3; gp110; glycoprotein 110; Nt3; Nts3
• Gene ID: 83576
• mRNA Refseq: NM_031767
• Protein Refseq: NP_113955
• UniProt ID: O54861