Recombinant Human TNFRSF18, Fc tagged
Cat.No. : | TNFRSF18-554H |
Product Overview : | Recombinant Human TNFRSF18 (Q9Y5U5-1) (Met1-Glu161), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cells. |
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Source : | Human Cells |
Species : | Human |
Tag : | His&GST |
Predicted N Terminal : | Gln 26 |
Form : | Lyophilized from sterile PBS, pH 7.4Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human TNFRSF18/Fc is a disulfide-linked homodimer. The reduced monomer comprises 377 amino acids and has a predicted molecular mass of 41.5 kDa. The apparent molecular mass of the protein is approximately 96 and 45 kDa in SDS-PAGE under re |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >90 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70oC. |
Storage : | Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Protein length : | Met1-Glu161 |
Gene Name : | TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens ] |
Official Symbol : | TNFRSF18 |
Gene ID : | 8784 |
mRNA Refseq : | NM_004195 |
Protein Refseq : | NP_004186 |
MIM : | 603905 |
UniProt ID : | Q9Y5U5 |
Chromosome Location : | 1p36.3 |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThis flexibility enables researchers like myself to tailor TNFRSF18 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.
Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.
The TNFRSF18 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
Q&As (5)
Ask a questionClinical trials are investigating TNFRSF18 agonists, such as monoclonal antibodies, in combination with other cancer treatments in various cancer types.
As of my knowledge cutoff date in January 2022, there were no approved TNFRSF18-targeted therapies for cancer. However, this may have changed since then.
Side effects may include immune-related adverse events, similar to those seen with other immunotherapies, and can range from mild to severe.
TNFRSF18-targeted therapies may enhance the body's immune response against cancer cells, leading to better tumor control and improved patient outcomes.
Yes, combination therapies involving TNFRSF18 agonists and other immunotherapies are under investigation to improve treatment efficacy.
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