Recombinant Full Length Human TNFRSF18 Protein, C-Flag-tagged

• Cat.No.: TNFRSF18-1320HFL
• Product Overview: Recombinant Full Length Human TNFRSF18 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 23.5 kDa
• AA Sequence: MAQHGAMGAFRALCGLALLCALSLG QRPTGGPGCGPGRLLLGTGTDARCC RVHTTRCCRDYPGEECCSEW DCMCVQPEFHCGDPCCTTCRHHPCP PGQGVQSQGKFSFGFQCIDCASGTF SGGHEGHCKPWTDCTQFGFL TVFPGNKTHNAVCVPGSPPAEPLGW LTVVLLAVAACVLLLTSAQLGLHIW QLRSQCMWPRETQLLLEVPP
  STEDARSCQFPEEERGERSAEEKGR LGDLWVTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction

Gene Information

• Gene Name: TNFRSF18 TNF receptor superfamily member 18 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF18
• Synonyms: AITR; GITR; CD357; GITR-D; ENERGEN
• Gene ID: 8784
• mRNA Refseq: NM_004195.3
• Protein Refseq: NP_004186.1
• MIM: 603905
• UniProt ID: Q9Y5U5