Recombinant Rhesus macaque Tnfrsf18 Protein, Fc-tagged
Cat.No. : | Tnfrsf18-666R |
Product Overview : | Recombinant Rhesus macaque Tnfrsf18 protein with Fc tag was expressed in HEK293. |
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Description : | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Source : | HEK293 |
Species : | Rhesus macaque |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | 41.3 kDa |
Protein length : | 234 |
AA Sequence : | VARHGAMCASGTLCCLALLCAASLG QRPTGGPGCGPGRLLLGTGKDARCC RVHPTRCCGDYQGEECCSEWDCVCV QPEFHCGNPCCTTCQHHPCPSGQGV QPQGKFSFGFRCVDCALGTFSRGHD GHCKPWTDCTQFGFLTVFPGNKTHN AVCVPGSPPAEPPGWLTIVLLAVAA CVLLLTSAQLGLHIWQLRKTQLLLE VPPSTEDASSCQFPEEERGERLAEE KGRLGDLWV |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | Tnfrsf18 |
Synonyms : | TNFRSF18; tumor necrosis factor receptor superfamily, member 18; tumor necrosis factor receptor superfamily member 18; |
Gene ID : | 699559 |
mRNA Refseq : | XM_015115547 |
Protein Refseq : | XP_014971033 |
UniProt ID : | F7DDV8 |
Products Types
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◆ Lysates | ||
TNFRSF18-1245RCL | Recombinant Rat TNFRSF18 cell lysate | +Inquiry |
TNFRSF18-1143HCL | Recombinant Human TNFRSF18 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThis flexibility enables researchers like myself to tailor TNFRSF18 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.
Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.
The TNFRSF18 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
Q&As (5)
Ask a questionClinical trials are investigating TNFRSF18 agonists, such as monoclonal antibodies, in combination with other cancer treatments in various cancer types.
As of my knowledge cutoff date in January 2022, there were no approved TNFRSF18-targeted therapies for cancer. However, this may have changed since then.
Side effects may include immune-related adverse events, similar to those seen with other immunotherapies, and can range from mild to severe.
TNFRSF18-targeted therapies may enhance the body's immune response against cancer cells, leading to better tumor control and improved patient outcomes.
Yes, combination therapies involving TNFRSF18 agonists and other immunotherapies are under investigation to improve treatment efficacy.
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