Recombinant Mouse Tnfrsf18, Fc Chimera
Cat.No. : | Tnfrsf18-2087M |
Product Overview : | Recombinant MouseTnfrsf18 Produced inHEK 293 cells.The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1. MW=45kDa (SDS-PAGE). |
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Species : | Mouse |
Source : | HEK293 |
Tag : | Fc |
ProteinLength : | 20-152 a.a. |
Description : | GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies. |
Concentration : | 1mg/ml after reconstitution. |
Purity : | ≥90% (SDS-PAGE). |
Formulation : | Lyophilized. Contains PBS. |
Endotoxin Content : | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
Reconstitution : | Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. |
Specificity : | Binds mouse GITRL. |
Term Storage : | -20°C. |
Handling : | Stable for at least 6 months after receipt when stored at -20°C. |
Stability : | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
Gene Name | Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 [ Mus musculus ] |
Synonyms | Tnfrsf18; tumor necrosis factor receptor superfamily, member 18; AITR; Gitr;tumor necrosis factor receptor superfamily member 18; OTTMUSP00000011817; OTTMUSP00000011818; glucocorticoid-induced TNFR-related protein |
Gene ID | 21936 |
mRNA Refseq | NM_009400 |
Protein Refseq | NP_033426 |
UniProt ID | O35714 |
Chromosome Location | 4 E |
Pathway | Cytokine-cytokine receptor interaction |
Function | protein binding; receptor binding |
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Not For Human Consumption!
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