| Description : |
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
47.9 kDa |
| Protein Length : |
455 |
| AA Sequence : |
MGLSTVPDLLLPLVLLELLVGIYPS GVIGLVPHLGDREKRDSVCPQGKYI HPQNNSICCTKCHKGTYLYNDCPGP GQDTDCRECESGSFTASENHLRHCL SCSKCRKEMGQVEISSCTVDRDTVC GCRKNQYRHYWSENLFQCFNCSLCL NGTVHLSCQEKQNTVCTCHAGFFLR ENECVSCSNCKKSLECTKLCLPQIE NVKGTEDSGTTVLLPLVIFFGLCLL SLLFIGLMYRYQRWKSKLYSIVCGK STPEKEGELEGTTTKPLAPNPSFSP TPGFTPTLGFSPVPSSTFTSSSTYT PGDCPNFAAPRREVAPPYQGADPIL ATALASDPIPNPLQKWEDSAHKPQS LDTDDPATLYAVVENVPPLRWKEFV RRLGLSDHEIDRLELQNGRCLREAQ YSMLATWRRRTPRREATLELLGRVL RDMDLLGCLEDIEEALCGPAALPPA PSLLR |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
