Recombinant Human TNFRSF1A Protein, Fc-tagged

Cat.No. : TNFRSF1A-457H
Product Overview : Recombinant human TNFRSF1A protein with Fc tag was expressed in HEK293.
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Description : This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized
Protein Length : 455
AA Sequence : MGLSTVPDLLLPLVLLELLVGIYPS GVIGLVPHLGDREKRDSVCPQGKYI HPQNNSICCTKCHKGTYLYNDCPGP GQDTDCRECESGSFTASENHLRHCL SCSKCRKEMGQVEISSCTVDRDTVC GCRKNQYRHYWSENLFQCFNCSLCL NGTVHLSCQEKQNTVCTCHAGFFLR ENECVSCSNCKKSLECTKLCLPQIE NVKGTEDSGTTVLLPLVIFFGLCLL SLLFIGLMYRYQRWKSKLYSIVCGK STPEKEGELEGTTTKPLAPNPSFSP TPGFTPTLGFSPVPSSTFTSSSTYT PGDCPNFAAPRREVAPPYQGADPIL ATALASDPIPNPLQKWEDSAHKPQS LDTDDPATLYAVVENVPPLRWKEFV RRLGLSDHEIDRLELQNGRCLREAQ YSMLATWRRRTPRREATLELLGRVL RDMDLLGCLEDIEEALCGPAALPPA PSLLR
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : TNFRSF1A tumor necrosis factor receptor superfamily, member 1A [ Homo sapiens (human) ]
Official Symbol : TNFRSF1A
Synonyms : TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; TNFR1; tumor necrosis factor receptor superfamily member 1A; CD120a; TNF R; TNF R I; TNF R55; TNFAR; TNFR60; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; FPF; p55; p60; TBP1; TNF-R; p55-R; TNFR55; TNF-R-I; TNF-R55; MGC19588;
Gene ID : 7132
mRNA Refseq : NM_001065
Protein Refseq : NP_001056
MIM : 191190
UniProt ID : P19438

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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