Recombinant Human TTR protein(Met1-Glu147), His-tagged

• Cat.No.: TTR-1284H
• Product Overview: Recombinant Human TTR (NP_000362.1) (Met 1-Glu 147) with a C-terminal polyhistidine tag was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Met1-Glu147
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bio-activity: Measured by its binding ability in a functional ELISA.Immobilized recombinant human TTR-His at 10 μg/ml (100 μl/well) can bind recombinant Canine RBP4-Fc with a linear range of 0.3-10.0 μg/ml.
• Molecular Mass: The secreted recombinant human TTR comprises 138 amino acids with a predicted molecular mass of 15.2 kDa.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 97 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: TTR transthyretin [ Homo sapiens ]
• Official Symbol: TTR
• Synonyms: TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin, amyloidosis type I; CTS; CTS1; PALB; TBPA
• Gene ID: 7276
• mRNA Refseq: NM_000371
• Protein Refseq: NP_000362
• MIM: 176300
• UniProt ID: P02766

Reviews

07/14/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

11/26/2021

I have a dedicated staff member who contacts me and keeps me informed on the progress of custom protein production.

01/02/2021

The purchased product information is in line with the advertising campaign and is conducive to obtaining accurate experimental results.

Q&As

What are the main physiologic functions of TTR?

TTR is involved in the transport of thyroxine and retinol and plays a role in processes such as protein degradation.

How are RAGE proteins related to TTR proteins?

RAGE proteins interact with TTR proteins and are involved in the regulation of TRR expression.

In which animals is TTR expressed?

TTR proteins are highly conserved and are found in several vertebrates, such as humans, rats, sheep, and chickens.

Where is TTR primarily synthesized?

TTR is mainly synthesized in the liver.

TTR is closely linked to research on what diseases

TTR is associated with a variety of diseases including amyloidosis TTR (ATTR), dementia (AD) and neurological damage.