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Recombinant Human TTR protein, His-tagged

Cat.No. : TTR-3880H
Product Overview : Recombinant Human TTR protein (Gly21-Glu147), fused to His-tag at the N-terminus, was expressed in HEK293 Cells.
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Description : Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : His
Form : Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass : The recombinant human TTR consists of 142 amino acids and predicts a molecular mass of 15.7 kDa.
Protein length : Gly21-Glu147
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : >(10.9+84.3)% as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : TTR
Official Symbol : TTR
Synonyms : CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
Gene ID : 7276
mRNA Refseq : NM_000371.4
Protein Refseq : NP_000362.1
MIM : 176300
UniProt ID : P02766

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the main physiologic functions of TTR? 07/14/2022

TTR is involved in the transport of thyroxine and retinol and plays a role in processes such as protein degradation.

How are RAGE proteins related to TTR proteins? 11/23/2021

RAGE proteins interact with TTR proteins and are involved in the regulation of TRR expression.

In which animals is TTR expressed? 06/07/2021

TTR proteins are highly conserved and are found in several vertebrates, such as humans, rats, sheep, and chickens.

Where is TTR primarily synthesized? 03/05/2021

TTR is mainly synthesized in the liver.

TTR is closely linked to research on what diseases 10/22/2020

TTR is associated with a variety of diseases including amyloidosis TTR (ATTR), dementia (AD) and neurological damage.

Customer Reviews (3)

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Reviews
07/14/2022

    Timely delivery, so I got the desired experimental results in the shortest possible time.

    11/26/2021

      I have a dedicated staff member who contacts me and keeps me informed on the progress of custom protein production.

      01/02/2021

        The purchased product information is in line with the advertising campaign and is conducive to obtaining accurate experimental results.

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