UGT1A1

  • Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A1

  • Overview

    The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
  • Synonyms

    UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Insect cells
  • Mamanlian cells
  • Mammalian Cell
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UGT1A1-1118H Active Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human N/A
Human UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Myc/DDK
Human UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 N/A
Human UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E. coli His
Human UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast His
Human UGT1A1-97H Active Recombinant Human UGT1A1 Protein Insect cells
Human UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli His
Human UGT1A1-1019H Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UGT1A1-1927HFL Recombinant Full Length Human UGT1A1, Flag-tagged Mamanlian cells Flag
Mouse UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cell His
Mouse UGT1A1-9885M-B Recombinant Mouse UGT1A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse UGT1A1-9885M Recombinant Mouse UGT1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ugt1a1-535R Recombinant Rat Ugt1a1 Protein, His-tagged E.coli N-His Ile62-Ala170
Mus musculus (Mouse) RFL25202MF Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-1(Ugt1A1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-535)
Rattus norvegicus (Rat) RFL28186RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-1(Ugt1A1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-535)
Rhesus Macaque UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque UGT1A1-4912R-B Recombinant Rhesus Macaque UGT1A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque UGT1A1-4912R Recombinant Rhesus Macaque UGT1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UGT1A1 Related Articles

UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsALDH1B1;SORD;AKR1A1B;UGDH;UGT5G1;ALDH3A2A;UGT2A3;AKR1B10;AKR1B1L
Ascorbate and aldarate metabolismGULO;UGDH;UGT1A9;UGT2A1;ALDH2;GKUP;MIOX;UGT2A2;UGT1A6B
Steroid hormone biosynthesisCYP2C45;UGT1A3;CYP19A1B;AKR1C3;CYP2C54;CYP3A25;UGT1A7C;CYP11C1;HSD17B12B
Starch and sucrose metabolismHK3;UGT1A9;GBA3;TREH;UGP2A;KL;UGT1A2;UXS1;AMY2B
Retinol metabolismADH2-2;CYP2C50;CYP3A65;CYP26C1;RPE65;CYP2C54;UGT1A7;RDH11;ADH2-1
Porphyrin and chlorophyll metabolismALAS2;CPOX;HMOX1A;UGT1A7C;UGT2A1;UGT1A4;FXN;COX10;HMOX2A
Metabolism of xenobiotics by cytochrome PGSTP2;GSTA5;ALDH3A1;GSTM2;UGT1A9;MGST1;CYP1A;MGST3;CBR1
Drug metabolism - cytochrome PGSTM4;GSTAL;MAOB;GSTM7;GSTT2;MGST1.1;ALDH1A3;FMO4;UGT1A7C
Drug metabolism - other enzymesUGT1A1;UPP2;DPYS;UGT1A4;GMPS;UGT2A1;UGT1A2;UMPS;UGT1A3
Metabolic pathwaysCCBL1;HMBSB;TYRP1B;H6PD;PCCA;COX6B2;PKLR;PYGM;COX17
Chemical carcinogenesisADH1B;CYP2C50;SULT1A1;CYP3A5;SULT1A3;CYP2C38;CYP2C70;GSTM5;Nat3

UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingNCOA1;APOA5;BCHE;RYR2;AKIRIN2;ADORA2A;BCL10;CASP2;RPA2
enzyme inhibitor activityCD46;FRY;OAZ2B;SCG5;ATPIF1;TXNIP;PDE6H;KIAA1967;PLN
glucuronosyltransferase activityUGT1B5;UGT5A3;UGT2B15;B3GAT3;EXT2;UGT5G1;GYLTL1B;UGT1A2;UGT1B1
NOT glucuronosyltransferase activityUGT1A6;UGT1A4;UGT1A1;UGT1A3;UGT1A9;UGT1A7
protein heterodimerization activityTLR2;TAF6L;ARNT;SCUBE1;TP53;PIK3R2;BCL2L2;DRD2;KATNB1
protein homodimerization activityBCL2;ADRA2A;LRRC41;DAPK3;TPR;ATPIF1;RBM11;NUDT16;PAFAH1B1
retinoic acid bindingUGT1A2;UGT1A1;LCN12;UGT1A7;SERPINA5;NR2F2;CRABP1A;CRABP1B;LRAT
steroid bindingESR2B;PAQR8;UGT1A1;CYP21A1;NR3C2;PGR;PAQR5;CYP21A2;PAQR7

UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.

UGDH; q9wmx2-pro_0000037550

Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What is the function of UGT1A1? 07/14/2022

UGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.

What is the relationship between bilirubin and UGT1A1? 01/24/2022

Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.

What diseases is UGT1A1 involved in? 11/23/2021

UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.

Where is UGT1A1 mainly expressed? 03/11/2021

UGT1A1 is mainly expressed in the liver.

What are the effects of mutations in the UGT1A1 gene? 02/09/2021

Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.

Customer Reviews (2)

Write a review
Reviews
08/12/2022

    The product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.

    05/14/2022

      Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.

      Ask a Question for All UGT1A1 Products

      Required fields are marked with *

      My Review for All UGT1A1 Products

      Required fields are marked with *

      logo

      FOLLOW US

      Terms and Conditions        Privacy Policy

      Copyright © 2024 Creative BioMart. All Rights Reserved.

      Contact Us

      • /

      Stay Updated on the Latest Bioscience Trends