UGT1A1

  • Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A1

  • Overview

    The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.

  • Synonyms

    UGT1A1;UDP glucuronosyltransferase 1 family, polypeptide A1;GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1;UDP-glucuronosyltransferase 1-1;UGT1A;UGT-1A;UGT1*1;UGT1.1;UGT1-01;UDP-glucuronosyltransferase 1-A;UDP-glucuronosyltransferase 1A1;bilirubin-specific UDPGT isozyme 1;bilirubin UDP-glucuronosyltransferase 1-1;bilirubin UDP-glucuronosyltransferase isozyme 1;UDP glycosyltransferase 1 family, polypeptide A1;GNT1;UGT1;UDPGT;HUG-BR1;BILIQTL1;UDPGT 1-1

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Rhesus macaque
  • Mus musculus
  • Rat
  • E.coli
  • Insect cells
  • Human
  • Mammalian Cells
  • HEK293
  • Yeast
  • His
  • Non
  • DDK
  • Myc
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli Human His 26-490 a.a.
UGT1A1-97H Active Recombinant Human UGT1A1 Protein Insect cells Human
UGT1A1-1118H Active Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human Human Non
UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cells Mouse His
UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Human DDK&Myc
UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cells Zebrafish His
UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cells Rhesus macaque His
UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 Human Non
RFL25202MF Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-1(Ugt1A1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (30-535)
RFL28186RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-1(Ugt1A1) Protein, His-Tagged E.coli Rat His Full L. Full Length of Mature Protein (30-535)
UGT1A1-1019H Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E.coli Human His 26-276 a.a.
UGT1A1-1927HFL Recombinant Full Length Human UGT1A1, Flag-tagged Mammalian Cells Human Flag Full L.
UGT1A1-4912R Recombinant Rhesus Macaque UGT1A1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
UGT1A1-4912R-B Recombinant Rhesus Macaque UGT1A1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Ugt1a1-535R Recombinant Rat Ugt1a1 Protein, His-tagged E.coli Rat His Ile62-Ala170
UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast Human His
UGT1A1-9885M Recombinant Mouse UGT1A1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
UGT1A1-9885M-B Recombinant Mouse UGT1A1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ascorbate and aldarate metabolism ALDH9A1B,UGT1A6B,ALDH7A1,UGT1A3,UGT1AB,ALDH9A1A.1,UGT1A6A,ALDH2.1,GKUP,ALDH1B1
    Chemical carcinogenesis SULT1A4,CYP1B1,CYP2E1,SULT1A1,GSTM7,SULT1A3,GSTP2,CYP3A5,NAT2,CYP2C8
    Metabolic pathways PNLIP,HPDA,ALG9,ATP5IA,BST1,PFKL,UQCRQ,ACLY,SPR,GCDH
    Drug metabolism - cytochrome P MAOB,MAOA,UGT1A7C,GSTA4,GSTT2,UGT2B15,UGT2A2,UGT1A4,GSTM7,UGT2B7
    Retinol metabolism ADH2-1,CYP3A41B,RETSAT,CYP2C54,UGT2B15,RDH8B,Aldh1a7,SDR16C5B,DHRS4L2,RDH10A
    Drug metabolism - other enzymes UGT1A2,UCK1,IMPDH1A,UCK2,UGT1A9,TK2,UGT1A7,PNAT10,CES1C,CES2
    Steroid hormone biosynthesis CYP3A7-CYP3AP1,CYP19A1A,CYP11C1,HSD17B1,COMTA,UGT1A7C,HSD17B3,HSD11B1,SRD5A3,CYP2C39
    Pentose and glucuronate interconversions AKR1B1,AKR1A1B,UGT2A1,UGT2B7,KL,AKR1B10,GKUP,UGP2A,UGT1A6B,AKR1B8
    Metabolism of xenobiotics by cytochrome P GSTA1,MGST1,GSTM,GSTM1,UGT2A2,EPHX1,HSD11B1,AKR7A3,CBR3,GSTA4

    Protein Function

    UGT1A1 has several biochemical functions, for example, enzyme binding,enzyme inhibitor activity,glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.

    Function Related Protein
    NOT glucuronosyltransferase activity UGT1A7,UGT1A9,UGT1A3,UGT1A4,UGT1A6
    protein homodimerization activity SLC24A6,DAXX,ABP1,PSMD7,UGT1A6A,STC2,PVR,CEACAM1,RENBP,CD4
    enzyme binding EGFR,MAT2B,PGR,HDHD2,MLL5,DHCR24,ANK1,DDC,MST1R,NOTCH3
    glucuronosyltransferase activity UGT2A4,UGT5D1,UGT2B1,UGT1A5,UGT2A6,UGT5E1,UGT1A3,EXT2,LARGE,UGT5G2
    protein heterodimerization activity PHC2B,LTC4S,SOX8,GTF2A2,SUPT3H,CENPW,NAE1,ZHX1,ZHX3,HIST1H4L
    enzyme inhibitor activity PRPSAP1,ARRB1,TXNIP,APBA3,SLN,OAZ2B,HSPBP1,ATPIF1,SCG5,KIAA1967
    steroid binding CYP21A1,CYP3A4,HSD3B4,PGRMC1,PAQR7,ESR2,HSD17B10,ESRRA,CYP21A2,SERPINA6
    retinoic acid binding CRABP1B,UGT1A9,RARA,UGT1A3,CRABP1,CYP26B1,UGT1A2,CRABP2,LCN12,CYP26A1

    Interacting Protein

    UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.

    UGDH;q9wmx2-pro_0000037550

    Resources

    References

    • Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
    • Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).

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