UGT1A1 Protein


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Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A1
Background The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
Synonyms UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
    • Species :
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Rat
    • Rattus norvegicus (Rat)
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human
    • Insect cells
    • Mamanlian cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • Flag
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A1-1118H Active Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human N/A Inquiry
    Human UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Mouse UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cell His Inquiry
    Rhesus Macaque UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cell His Inquiry
    Zebrafish UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cell His Inquiry
    Human UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 N/A Inquiry
    Mus musculus (Mouse) RFL25202MF Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-1(Ugt1A1) Protein, His-Tagged E.coli expression system His Inquiry
    Rattus norvegicus (Rat) RFL28186RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-1(Ugt1A1) Protein, His-Tagged E.coli expression system His Inquiry
    Human UGT1A1-1927HFL Recombinant Full Length Human UGT1A1, Flag-tagged Mamanlian cells Flag Inquiry
    Rat Ugt1a1-535R Recombinant Rat Ugt1a1 Protein, His-tagged E.coli N-His Inquiry
    Human UGT1A1-1019H Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E. coli His Inquiry
    Human UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli His Inquiry
    Human UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast His Inquiry
    Human UGT1A1-97H Recombinant Human UGT1A1 Protein Insect cells Inquiry

    UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions ALDH1B1; UGDH; DCXR; SORD; UGT1AB; UGT1A6A; AKR1B7; UGP2; AKR1B10; UGT1A6
    Ascorbate and aldarate metabolism ALDH7A1; ALDH2.1; UGT1A7C; UGT1AB; UGT1A4; UGT1A6A; UGT1A2; UGT1A7; ALDH2.2; UGT2A3
    Steroid hormone biosynthesis UGT2A1; UGT1A9; CYP2C54; STS; SRD5A3; HSD17B1; SULT2ST3; UGT2A3; UGT1A6A; UGT1A6B
    Starch and sucrose metabolism UGT5G1; AMY2A5; PGM2L1; UGT2B7; GANC; GBA3; AMY2A; UGT1A6; G6PC2; AMY2A4
    Retinol metabolism BCO1L; UGT1A9; CYP2C70; RETSATL; ALDH1A1; AOX3; LRATA; DHRS3B; CYP2C37; CYP3A7
    Porphyrin and chlorophyll metabolism CP; MMAB; HMOX2; ALAS1; BLVRA; UGT1A6; PPOX; UROD; EARS2; CPOX
    Metabolism of xenobiotics by cytochrome P GSTA4; UGT2A1; GSTA3; DHDHL; MGST1.1; UGT1A6; CYP1A; CBR3; GSTA5; GSTA1
    Drug metabolism - cytochrome P MGST1.1; GSTA3; AOX3; UGT2A1; GSTA1; UGT1A7; FMO6P; UGT1A6A; UGT2A3; FMO2
    Drug metabolism - other enzymes DPYS; UCK2; UGT2A2; UGT1A1; UGT2A3; XDH; UGT1A4; NAT2; CES2; UGT1A3
    Metabolic pathways QPRT; DHRS3; PIGL; ALDH3A2A; B3GALNT1; PIGF; UGT1A9; RDH8B; ITPKB; ATP5L
    Chemical carcinogenesis ADH1A; GSTA3; CYP2A13; CYP3A7; GSTT1; GSTM3; GSTA5; SULT1A3; UGT1A6; CYP2A6

    UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding SCNM1; ARRB2; PTPLAD2; RAC1; RAD9; SLPI; IQCB1; APOA1; HDAC1; THRB
    enzyme inhibitor activity KIAA1967; UGT1A1; ANGPTL4; HSPBP1; SCG5; WFIKKN1; CALU; OAZ2B; CD46; ANGPTL3
    glucuronosyltransferase activity EXT1; UGT1A9; UGT1A6B; GYLTL1B; UGT1B3; UGT1A4; UGT5G2; UGT1A7C; UGT2A3; UGT5C1
    NOT glucuronosyltransferase activity UGT1A7; UGT1A6; UGT1A4; UGT1A9; UGT1A1; UGT1A3
    protein heterodimerization activity PDSS1; DRAP1; BCL2A1A; GAD2; MAFG; SOX4; BAD; BCL2L1; TPD52L1; SRY
    protein homodimerization activity SYT14; PARK7; ZNF174; CACYBP; DMRT3; UGT1A9; CALCOCO2; ACHE; ZFP365; BAXB
    retinoic acid binding CRABP1A; SERPINA5; UGT1A2; RARA; NR2F2; CRABP1; LRAT; CYP26A1; UGT1A3; LCN12
    steroid binding HSD17B10; CYP21A1; ESR2; SERPINA6; ESR1; NR3C2; ESRRB; HSD3B5; PGRMC1; NR3C1

    UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.

    UGDH; q9wmx2-pro_0000037550

    Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
    Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).

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