UGT1A1
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A1
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Overview
The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin. -
Synonyms
UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Insect cells
- Mamanlian cells
- Mammalian Cell
- Yeast
- Flag
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose and glucuronate interconversions | UGT1A2;UGP2;UGT1A1;UGT2A1;ALDH3A2;ALDH2;ALDH3A2A;UGP2A;UGT1AB |
| Ascorbate and aldarate metabolism | UGT1A2;UGT2A2;RGN;UGT1A7;ALDH1B1;UGT1A6;ALDH3A2A;ALDH2.2;UGT2B7 |
| Steroid hormone biosynthesis | HSD3B2;HSD3B4;COMTB;UGT1A7C;CYP3A7-CYP3AP1;CYP19A1B;UGT1A2;UGT1A6B;CYP3A7 |
| Starch and sucrose metabolism | PYGB;GANC;UGT2A2;KL;GPIA;UGT1A9;UGDH;PGM2L1;AMY1A |
| Retinol metabolism | UGT1A6A;DHRS4L2;DHRS3B;ADH1;CYP2C18;PNPLA4;UGT1A6B;AOX3L1;CYP3A41A |
| Porphyrin and chlorophyll metabolism | GUSB;UGT2B15;UGT2A2;UGT1A7;HMOX2;HMBSB;CP;MMAB;HMBSA |
| Metabolism of xenobiotics by cytochrome P | GSTA5;AKR7A5;GSTT1B;UGT1A4;MGST3;UGT2B7;GSTM7;GSTM3;CYP1A |
| Drug metabolism - cytochrome P | MAOB;UGT1A3;ALDH3B1;UGT1A6A;MGST1.2;ALDH3B2;GSTM;UGT2A2;FMO2 |
| Drug metabolism - other enzymes | Nat3;IMPDH1A;TPMT.1;CES2;UGT1A7C;TYMP;NAT1;CDA;CES1C |
| Metabolic pathways | MTMR14;GPIA;CKMT2B;ATP5J2;PRPS1B;CYP4F3;POLR2C;COX5AA;COX5B |
| Chemical carcinogenesis | GSTP2;ALDH3B1;MGST2;GSTA3;GSTM3;UGT2B15;GSTA1;GSTA2;CBR1 |
UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | CBX3;MTA1;BACE1;HDAC6;NOTCH1;LYN;HMGA1;HSPA6;STUB1 |
| enzyme inhibitor activity | UGT1A7;ATPIF1B;OAZ2B;CSN2;UGT1A9;OAZ1A;PLN;NOTCH1;CALU |
| glucuronosyltransferase activity | UGT1B1;UGT1B2;UGT1A4;LARGE;EXT1;UGT1A1;UGT5A1;UGT2B6;UGT1A6B |
| NOT glucuronosyltransferase activity | UGT1A6;UGT1A9;UGT1A7;UGT1A1;UGT1A3;UGT1A4 |
| protein heterodimerization activity | TPD52;CEBPA;HIST1H2BP;NFKB1;NKX2-5;GTF2A1;ADIPOR2;SFRP5;GUCY1A3 |
| protein homodimerization activity | PVRL2;VPS25;NUDT21;VWF;ATIC;MAP3K13;NTRK2;GCA;ATG7 |
| retinoic acid binding | UGT1A3;CRABP2;UGT1A7;SERPINA5;CRABP1A;CRABP1;CRABP2B;UGT1A2;CRABP1B |
| steroid binding | PAQR8;CYP21A1;CYP21A2;HSD3B5;HSD11B2;ESRRGB;PGRMC2;SERPINA6;PAQR7B |
UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.
UGDH; q9wmx2-pro_0000037550
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Q&As (5)
Ask a questionUGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.
Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.
UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.
UGT1A1 is mainly expressed in the liver.
Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.
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