ugt1a1

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ugt1a1

Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A1
Background The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
Synonyms UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A1-1019H Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UGT1A1-1118H Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human N/A
    Human UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E. coli His
    Human UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli His
    Human UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 N/A
    Human UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast His
    Human UGT1A1-97H Recombinant Human UGT1A1 Protein Insect cells
    Mouse UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cell His
    Rhesus Macaque UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cell His
    Zebrafish UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cell His

    ugt1a1 involved in several pathways and played different roles in them. We selected most pathways ugt1a1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ugt1a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions GKUP; UGT2B15; UGT1A3; ALDH2.1; ALDH2; UGT2A1; CRYL1; ALDH2.2; UGT1A1; DHDHL
    Ascorbate and aldarate metabolism UGT1A6A; ALDH9A1A.1; UGT1A6B; ALDH2.1; UGT1A7C; GULO; RGN; ALDH3A2A; UGT2B15; UGT2A2
    Steroid hormone biosynthesis CYP2C37; CYP2C39; HSD17B2; HSD3B2; UGT1A2; UGT2B15; CYP2D10; HSD3B4; CYP19A1B; HSD17B1
    Starch and sucrose metabolism GPIB; PYGB; UGT1A7C; UXS1; HK2; UGP2; UGT2B15; AMY2A3; UGT1AB; GBA3
    Retinol metabolism DHRS9; DHRS4L2; UGT2B15; RDH5; CYP26C1; CYP2C18; CYP2C50; SDR16C5B; CYP3A65; CYP3A7
    Porphyrin and chlorophyll metabolism COX15; GUSB; COX10; HMOX1; UGT1A6B; UROD; UGT1A6A; UGT2B15; EPRS; HEPH
    Metabolism of xenobiotics by cytochrome P CBR1L; DHDHL; GSTA4; DHDH; AKR7A2; CBR2; UGT1A7C; AKR7A3; MGST1.2; ALDH1A3
    Drug metabolism - cytochrome P GSTM1; UGT1A6B; FMO2; UGT1A9; UGT5G1; UGT2B7; UGT2A2; ALDH3B1; MAOA; UGT1A2
    Drug metabolism - other enzymes UGT2A3; UPP1; UPB1; UGT2A2; UGT2B15; UCK2A; ITPA; UGT1A6A; CES2; HPRT1
    Metabolic pathways PIP5K1AA; MMAB; EPRS; IMPA2; PPOX; PRPS1L1; NDUFS3; FBP1B; PLA2G10; PCK2
    Chemical carcinogenesis CYP2C39; CYP2A6; AHA-1; ARNT; GSTT2B; UGT1A9; UGT1A2; GSTP2; UGT1A6A; UGT2A2

    ugt1a1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ugt1a1 itself. We selected most functions ugt1a1 had, and list some proteins which have the same functions with ugt1a1. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding H2AFX; KIAA1967; ESR2; NCOA1; PRKCD; ATXN10; UBE4B; PHKG2; MARCH6; CD4
    enzyme inhibitor activity PDE6H; KIAA1967; OAZ2A; TAE1; PPP1R12A; APBA3; UGT1A9; OAZ2B; ATPIF1B; GCHFR
    glucuronosyltransferase activity UGT3A2; UGT5A2; LARGE; UGT5G2; UGT2A4; UGT2A3; UGT3A1; UGT1B4; UGT1AB; UGT5D1
    NOT glucuronosyltransferase activity UGT1A1; UGT1A3; UGT1A6; UGT1A9; UGT1A4; UGT1A7
    protein heterodimerization activity BCL2A1A; PDGFB; PVALB; HIST1H3D; BAD; GCLM; IRAK1; KCNA3; H2AFV; TOP2A
    protein homodimerization activity SNX1; PLCB1; GGCT; C6orf108; TBX18; HIF1AN; NR4A3; OXCT1; Defa-rs7; HLCS
    retinoic acid binding CRABP2B; LCN12; CRABP1; CRABP1B; UGT1A2; PTGDSB; NR2F2; CRABP2; UGT1A3; RARA
    steroid binding ESRRGB; NR3C1; SERPINA6; PGR; ESRRG; PAQR7; PAQR5; HSD3B5; PAQR5A; HSD17B10

    ugt1a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ugt1a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ugt1a1.

    UGDH; q9wmx2-pro_0000037550

    Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
    Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).

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