UGT1A1 Protein

UGT1A1

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UGT1A1

Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A1
Background The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
Synonyms UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat Ugt1a1-535R Recombinant Rat Ugt1a1 Protein, His-tagged E.coli N-His
    Human UGT1A1-1019H Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UGT1A1-1118H Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human N/A
    Human UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E. coli His
    Human UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli His
    Human UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 N/A
    Human UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast His
    Human UGT1A1-97H Recombinant Human UGT1A1 Protein Insect cells
    Mouse UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cell His
    Rhesus Macaque UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cell His
    Zebrafish UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cell His

    UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions UGT2A3; RPE; Akr1b3; ALDH3A2; UGP2A; UGT1A7C; AKR1A1B; UGT1A9; UGT2B7; UGT2A1
    Ascorbate and aldarate metabolism UGT2A3; UGT1A1; ALDH2.2; UGT1A6B; UGT5G1; UGDH; UGT1A7; ALDH9A1; RGN; UGT1A6
    Steroid hormone biosynthesis UGT1A7C; H2-KE6; UGT1A1; CYP3A25; HSD17B12B; CYP2C38; STS; UGT1A6B; CYP21A1; COMTA
    Starch and sucrose metabolism PGM2; HK1; AMY2A; AMY1B; AGL; PYGM; PGM1; PYGL; UGT1A7C; G6PC
    Retinol metabolism UGT1A7; CYP3A7-CYP3AP1; CYP3A65; UGT1AB; CYP3A25; BCMO1; AOX3; RETSAT; CYP2C45; UGT2A3
    Porphyrin and chlorophyll metabolism HMOX2A; UGT1A7C; UGT2A3; COX10; UGT1A6; UGT1A6B; BLVRA; HCCS; UGT1A2; ALAD
    Metabolism of xenobiotics by cytochrome P MGST1.1; AKR7A3; GSTO1; GSTM3; GSTA4; GSTM; GSTA3; DHDHL; EPHX1; MGST3
    Drug metabolism - cytochrome P UGT5G1; UGT1A9; GSTP2; UGT1A3; MGST3; FMO3; MGST1.1; GSTM; ALDH3B1; GSTM7
    Drug metabolism - other enzymes CES1C; DPYD; Ces2c; CYP2A6; IMPDH1; UGT1A6; UGT1AB; UGT2A1; TPMT.1; CES1D
    Metabolic pathways GPIB; SQLEA; ACOX3; UGDH; MOCS2; CYP2P7; OAT; B3GALT2; HIBADH; AMACR
    Chemical carcinogenesis SULT1A3; CYP3A43; GSTT2; CBR1; SULT2A1; ADH2-2; UGT1A4; ADH7; ALDH3B1; CYP3A5

    UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding CAT; UGT1A6B; ZNHIT6; AKT1; TOP2B; Ar; PPP1R3D; RPS19BP1; CYP2C8; KDM1A
    enzyme inhibitor activity APBA3; UGT1A9; HSPBP1; CALU; PDE6H; CSN2; UGT1A1; ANGPTL4; APOV1; ANGPTL3
    glucuronosyltransferase activity UGT5A5; UGT1A6A; UGT3A2; UGT1B4; UGT5B3; UGT1B1; UGT5C1; UGT5D1; UGT2A4; B3GAT3
    NOT glucuronosyltransferase activity UGT1A6; UGT1A9; UGT1A7; UGT1A4; UGT1A1; UGT1A3
    protein heterodimerization activity HIST2H4A; TAF11; HIST1H2AF; HEXB; BTBD11A; HNF1B; PHC2B; RARA; GABPB1; HIST1H2AB
    protein homodimerization activity TIMM9; PTS; CEACAM1; CBX1; ROPN1B; ADRB2; BMP2B; ATPIF1; CER1; MTUS2
    retinoic acid binding LRAT; UGT1A3; PTGDSB; CRABP1A; LCN12; CRABP1B; UGT1A7; CRABP2B; UGT1A1; CRABP2A
    steroid binding ESR2B; ESRRA; PGRMC2; ESR1; ESRRGB; ESR2; UGT1A1; SERPINA6; PAQR8; GPR30

    UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.

    UGDH; q9wmx2-pro_0000037550

    Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
    Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).

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