UGT1A1

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UGT1A1

Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A1
Background The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
Synonyms UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A1-1019H Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UGT1A1-1118H Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human N/A
    Human UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E. coli His
    Human UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli His
    Human UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 N/A
    Human UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast His
    Human UGT1A1-97H Recombinant Human UGT1A1 Protein Insect cells
    Mouse UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cell His
    Rhesus Macaque UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cell His
    Zebrafish UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cell His

    UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions AKR1B7; UGT1AB; UGT2B15; GKUP; UGT1A1; OXSR1; UGT1A4; AKR1B10; XYLB; RPE
    Ascorbate and aldarate metabolism ALDH7A1; ALDH3A2A; ALDH1B1; UGT1A6B; ALDH2.2; ALDH2.1; UGT1A9; UGT2A1; UGT1A4; UGT1A6
    Steroid hormone biosynthesis HSD3B2; HSD3B4; HSD17B3; UGT1A7; PPP1R2; CYP2C70; SRD5A1; UGT2A1; CYP7A1A; HSD17B12
    Starch and sucrose metabolism UGT2A3; UGT1A7; Amy1; UGT2A2; HK3; UGT1A9; AMY2A; ENPP3; GBE1; HK2
    Retinol metabolism AOX3L1; RDH10A; CYP2C55; HSD17B6; AOX2P; UGT2B7; RDH10; DHRS3; BCMO1; RDH8
    Porphyrin and chlorophyll metabolism HMOX2A; FECH; HMBSB; UGT2A3; HMOX2; UGT1A6; HCCS; CPOX; UGT5G1; CP
    Metabolism of xenobiotics by cytochrome P CYP2F2; UGT1A7; DHDH; CBR1; CBR2; AKR7A5; MGST1.1; GSTA5; GSTM2; CYP1A
    Drug metabolism - cytochrome P FMO5; GSTT1B; UGT2A2; GSTM4; UGT5G1; AOX1; GSTA2; ALDH3B2; FMO3; GSTAL
    Drug metabolism - other enzymes IMPDH2; NAT; UGT2B15; Nat3; UGT2B7; UMPS; IMPDH1A; TPMT; GMPS; UPP1
    Metabolic pathways GPAA1; CMPK2; ST3GAL4; KL; ACY1; IPMKB; MAT2AL; ATP5O; PLA2G4F; HDC
    Chemical carcinogenesis UGT2B7; GSTM3; CYP2A6; CYP2C9; AHA-1; CHRNA7; CYP2C8; UGT2A2; CYP2C19; CYP3A4

    UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding UGT1A6; BCL10; ERN1; A2M; NOTCH1; AXIN1; PTPLAD2; KDM4C; HDAC2; SELS
    enzyme inhibitor activity PLN; SLN; CALU; ARRB1; UGT1A1; PDE6G; ANGPTL3; APOV1; SCG5; FRY
    glucuronosyltransferase activity UGT1A6B; UGT1A6; UGT5A5; UGT2B15; UGT2A5; UGT5C2; UGT5A2; GYLTL1B; CSGALNACT1; UGT1A1
    NOT glucuronosyltransferase activity UGT1A4; UGT1A3; UGT1A7; UGT1A9; UGT1A1; UGT1A6
    protein heterodimerization activity FZD1; PVALB; RARA; TWIST1; HIST1H2BK; JAM2; HIST1H2AF; ROPN1B; CD3E; TOP2B
    protein homodimerization activity NPR3; NETO2; GRPEL1; CD2; PRPS1L1; FLT3LG; SPPL3; UBE4A; FAM109B; GSTM3
    retinoic acid binding SERPINA5; CRABP1B; CRABP2A; UGT1A9; CRABP2B; CYP26B1; UGT1A2; LRAT; LCN12; UGT1A3
    steroid binding PDIA2; ESRRA; SULT1E1; CYP3A4; PAQR7A; ESR2; SERPINA6; HSD3B4; ESR1; PGR

    UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.

    UGDH; q9wmx2-pro_0000037550

    Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
    Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).

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