USP14
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Official Full Name
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
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Background
Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD, and JAMM enzymes. In humans, there are three prot -
Synonyms
USP14; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); ubiquitin specific protease 14 (tRNA guanine transglycosylase); ubiquitin carboxyl-terminal hydrolase 14; TGT; ubiquitin thioesterase 14; deubiquitinating enzyme 14; ubiquitin thioles;
- Involved Pathway
- Protein Function
- Interacting Protein
- USP14 Related Research Area
USP14 involved in several pathways and played different roles in them. We selected most pathways USP14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
USP14 has several biochemical functions, for example, cysteine-type endopeptidase activity, endopeptidase inhibitor activity, proteasome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP14 itself. We selected most functions USP14 had, and list some proteins which have the same functions with USP14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | CTSSB.1;MALT1A;CFLARA;USP43A;USP9X;FMNL3;USP33;CASP8;CTSM |
| endopeptidase inhibitor activity | SERPINF2;MUG1;RECK;Cstb;C3B.2;C3A.6;C3A.3;A2ML;C5 |
| proteasome binding | USP14;ID1;PSMF1;UCHL5;UBD;DNAJB2;USP13;PSMG1;BAG6 |
| protein binding | PIK3IP1;HDAC7;SKAP1;NAPG;LDB1;SEMA7A;PDE2A;GABARAPL2;MEX3C |
| tRNA guanylyltransferase activity | CTU1;UAP1L1;PRIM2;USP14;CCDC111;THG1L |
| ubiquitin-specific protease activity | OTUB1;USP45;UCHL5;USP40;STAMBP;OTUD5;ATXN3L;USP5;DUB1 |
USP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP14.
PSMC1; UCHL5; PPP3CA; PSMD11; PSMD12; PSMD14; PSMD3; TXNL1; PSMD10; PSMC3; PSMB5; HLA-B; PSMC2; PSMC4; PSMD8
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