Recombinant Human USP14

• Cat.No.: USP14-692H
• Product Overview: Recombinant Human USP14 isproduced inE. coli.

Specification

• Cat. No.: USP14-692H
• Description: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: E. coli.
• Storage: -80°C.

Gene Information

• Gene Name: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) [ Homo sapiens ]
• Synonyms: USP14; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); deubiquitinating enzyme 14; tRNA-guanine transglycosylase, 60-kD subunit; ubiquitin carboxyl-terminal hydrolase 14; ubiquitin specific protease 14 (tRNA-guanine transglycosylase); ubiquitin thioesterase 14; ubiquitin thiolesterase 14; ubiquitin-specific processing protease 14; ubiquitin-specific-processing protease 14; TGT; EC 3.1.2.15
• Gene ID: 9097
• mRNA Refseq: NM_001037334
• Protein Refseq: NP_001032411
• MIM: 607274
• UniProt ID: P54578
• Chromosome Location: 18p11.32
• Function: cysteine-type endopeptidase activity; peptidase activity; proteasome binding; proteasome inhibitor activity; tRNA guanylyltransferase activity; ubiquitin thiolesterase activity; ubiquitin-specific protease activity