wt1
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  • Official Full Name
  • Wilms tumor 1
  • Background
  • Wilm’s Tumor (WT), a sporadic and familial childhood kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelioma.
  • Synonyms
  • WT1; Wilms tumor 1; GUD; Wilms tumor protein; AWT1; WAGR; WIT 2; amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1; WT33; NPHS4; WIT-2; EWS-WT1
Cat.#:WT1-1199HTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human WT1, Flag-tagged
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Cat.#:WT1-1210HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Wilms Tumor 1
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Cat.#:WT1-1402HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WT1 protein, His & GST-tagged
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Cat.#:WT1-17HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WT1 protein, His-tagged
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Cat.#:WT1-625HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WT1 Protein, His-tagged
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Cat.#:WT1-626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WT1 Protein, His-tagged
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Cat.#:Wt1-15MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Wt1 protein
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Cat.#:WT1-18590MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WT1 Protein
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Cat.#:WT1-6605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat WT1 Protein
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Cat.#:WT1-6769CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WT1
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Cat.#:WT1-278HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WT1 293 Cell Lysate
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Involved Pathway

WT1 involved in several pathways and played different roles in them. We selected most pathways WT1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with WT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
MEF2C; RUNX2; ELK4; MEN1; IGF1; SIN3A; NGFR; NR4A3; HHEX; CD14

Protein Function

WT1 has several biochemical functions, for example, C2H2 zinc finger domain binding, RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WT1 itself. We selected most functions WT1 had, and list some proteins which have the same functions with WT1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein EHMT2; HMGA2; THAP7; ZXDC; EHMT1; WT1; LEF1; U2AF2; EBF1; TAF9
Function RNA binding
Related Protein SETD1BA; IREB2; DIMT1; QKI2; UPF1; MOV10B.1; SNRPF; EXOSC3; EIF4H; PCBP4
Function protein binding
Related Protein CCNE1; AUNIP; KHDRBS3; RAI2; CNOT2; FAM108A1; LASP1; SYCE2; C16orf5; HMGB1
Function sequence-specific DNA binding
Related Protein NR1D4A; PRRX1B; MSXA; HOXA11A; NKX6.1; FOXK2; NR2F1; DMBX1B; NKX2.5; HOXA1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZKSCAN4; ZNF187; HOXA4A; SIM2; FOXG1C; FBXW7; PHTF1; ZNF711; GRHL2; TBX5B
Function transcription regulatory region DNA binding
Related Protein HOXA13; RFX6; OVOL2; ZFP161; NKX3; TAL1; ZFP746; FOXM1; H2AFY2; WNT11
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein RAX; ELK1; EPAS1; SOX2; NKX2-5; BCL11B; PAX5; CAMTA1; MYBL2; FOXK2
Function zinc ion binding
Related Protein CPSF4; ADAM15; ZGLP1; AMZ2; TRIM32; MMP13A; CPB1; LMO4A; NPSN; SEC24D

Interacting Protein

WT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WT1.
KRTAP10-8; KRT40; DVL3; NPM3; ZNF205; DIRAS3; NAT2; CCL5; KLK7; MDM2; TAOK1; CASZ1; THRSP

WT1 Related Articles

Qi, XW; Zhang, F; et al. Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis. SCIENTIFIC REPORTS 5:-(2015).
Sasine, JP; Schiller, GJ; et al. Emerging strategies for high-risk and relapsed/refractory acute myeloid leukemia: Novel agents and approaches currently in clinical trials. BLOOD REVIEWS 29:1-9(2015).