| Species : |
Human |
| Source : |
CHO |
| Description : |
Interleukin-12 (IL-12) is a cytokine with a wide range of biological activities and is mainly produced by activated inflammatory cells. However, it mainly acts on lymphocytes. IL-12 is a determinant of the Th1 cellular immune response and effectively promotes the production of Th1-like cytokines such as IFN-γ, and on the other hand inhibits the production of Th2-like factors such as IL-4 and IL-13, thereby suppressing the Th2-type response. reduction or absence of IL-12 results in a Th2-dominant immune response. In addition, IL-12 induces the production of a variety of cytokines, such as IFN-γ and IL-10. IL-12 is the most potent cytokine that induces the production of IFN-γ by T lymphocytes, especially activated T cells and NK cells, and many of the in vivo effects of IL-12 are exerted through the induction of IFN-γ. The biological activity of IL-12 is exerted through the production of IFN-γ by T cells and IL-12 receptors on NK cells are mediated. |
| Form : |
Lyophilized powder |
| Endotoxin : |
<20 EU/mg |
| Bio-activity : |
>1.0 x 10^6 IU/mg |
| Purity : |
>95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE. |
| Storage Buffer : |
10mM Phosphate-Buffered Saline (pH 7.2) |
| Storage : |
Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing. |
| Sterility : |
Sterility |
| Instructions : |
It is recommended that lyophilized GMP rhIL12 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration. |
