| Cat.No. : |
IL12-01HG
Optional Service: Optional requirements on this protein
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| Product Overview : |
Recombinant human IL12 protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines. |
| Description : |
Interleukin-12 (IL-12) is a cytokine with a wide range of biological activities and is mainly produced by activated inflammatory cells. However, it mainly acts on lymphocytes. IL-12 is a determinant of the Th1 cellular immune response and effectively promotes the production of Th1-like cytokines such as IFN-γ, and on the other hand inhibits the production of Th2-like factors such as IL-4 and IL-13, thereby suppressing the Th2-type response. reduction or absence of IL-12 results in a Th2-dominant immune response. In addition, IL-12 induces the production of a variety of cytokines, such as IFN-γ and IL-10. IL-12 is the most potent cytokine that induces the production of IFN-γ by T lymphocytes, especially activated T cells and NK cells, and many of the in vivo effects of IL-12 are exerted through the induction of IFN-γ. The biological activity of IL-12 is exerted through the production of IFN-γ by T cells and IL-12 receptors on NK cells are mediated. |
| Source : |
CHO-K1 |
| Species : |
Human |
| Form : |
Lyophilized powder |
| Endotoxin : |
<20 EU/mg |
| Bio-activity : |
>1.0 x 10^6 IU/mg |
| Purity : |
>95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE. |
| Storage Buffer : |
10mM Phosphate-Buffered Saline (pH 7.2) |
| Storage : |
Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing. |
| Sterility : |
Sterility |
| Instructions : |
It is recommended that lyophilized GMP rhIL12 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
