IL12

  • Official Full Name

    Interleukin 12

  • Overview

    Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.

  • Synonyms

    Il12a;interleukin 12a;p35;Ll12a;Il-12a;IL-12p35;MGC151228;MGC151232;interleukin 12a p35 subunit;interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35);P35;CLMF;NFSK;NKSF1;IL-12A;natural killer cell stimulatory factor 1, 35 kD subunit;cytotoxic lymphocyte maturation factor 1, p35;interleukin

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • CHO
  • HEK293
  • Mammalian Cells
  • Baculovirus
  • Yeast
  • Non
  • His
  • Fc
  • Flag
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL12-4327H Recombinant Human IL12A&IL12B heterodimer protein CHO Human Non
IL12-12H Recombinant Human IL12 Protein, His-tagged HEK293 Human His
IL12-158HG Active GMP Recombinant Human IL12 Protein HEK293 Human Non 23-219;23-328 a.a.
IL12-001H Active Recombinant Human IL12, HIgG1 Fc-tagged CHO Human Fc 23-328;57-253 a.a.
IL12-001M Active Recombinant Mouse IL12, HIgG1 Fc-tagged, mutant CHO Mouse Fc 23-328;57-253 a.a.
IL12-002H Active Recombinant Human IL12, HIgG1 Fc-tagged, mutant CHO Human Fc 23-328;57-253 a.a.
IL12-002M Active Recombinant Mouse IL12, HIgG1 Fc-tagged CHO Mouse Fc 1-335;23-215 a.a.
IL12-27R Active Recombinant Rat IL12 protein, His-tagged Mammalian Cells Rat His 23-335;23-215 a.a.
IL12-28M Active Recombinant Mouse IL12 protein, His-tagged Mammalian Cells Mouse His 1-215;1-335 a.a.
IL12B&IL12A-004H Active Recombinant Human IL12B&IL12A, HIgG1 Fc-tagged CHO Mouse Fc 23-328;57-253 a.a.
IL12-01HG Active GMP Recombinant Human IL12 Protein CHO Human
IL12-160HG Active GMP Recombinant Human IL12 Protein HEK293 Human
IL12-21M Recombinant Mouse Interleukin 12 Protein, His tagged Baculovirus Mouse His 23-335aa(p40)/23-215aa(p35)
IL12-417H Active Recombinant Human IL12 protein Yeast Human Non
Il12b-175M Active Recombinant Mouse interleukin 12 Protein, Flag tagged HEK293 Mouse Flag IL-12B: 23-335aa<br />IL-12A: 23-215aa
IL12-26R Recombinant Rat IL12 protein, His-tagged Mammalian Cells Rat His 23-335;23-215 a.a.
Il12-329M Recombinant Mouse Il12, Fc-tagged CHO Mouse Fc 1-335;23-215 a.a.
IL12-0097H Recombinant Human IL12 Protein HEK293 Human
IL12-1031M Active Recombinant Mouse IL12A & IL12B Heterotrimer Protein (Met1-Ala215 & Met1-Ser335), HlgG1 Fc-tagged HEK293 Mouse Fc Met1-Ala215 & Met1-Ser335
IL12-146H Human Interleukin-12 (rDNA derived) Reference standard Human Non
IL12-158H Recombinant Human IL12 Protein HEK293 Human Non Arg23-Ser219&Ile23-Ser328
IL12-159H Active Recombinant Human IL12 protein, His-tagged HEK293 Human His IL12A: Met 1-Ser 219 <br />IL12B: Met 1-Ser 328
IL12-159HB Recombinant Human IL12 protein, His-tagged, Biotinylated HEK293 Human His 1-219;1-328 a.a.
IL12-159HG Active GMP Recombinant Human IL12 protein HEK293 Human DNA sequence encoding Human p35 Subunit(UniProtKB/Swiss-Prot: P29459.2),p40 Subunit (NP_002178.2) was expressed with His tag at the C-terminal.
IL12-22H Recombinant Human Interleukin 12 Protein, His tagged Baculovirus Human His 23-328aa(p40)/23-219aa(p35)
IL12-249H Recombinant Human interleukin 12 Protein, His tagged HEK293 Human His IL-12B: 23-328aa<br />IL-12A: 23-219aa
Il12-258I Active Recombinant Rat Il12 Protein, His-tagged CHO Rat His
IL12-433H Recombinant Human IL12 Protein, His-Avi-tagged HEK293 Human Avi&His Ile23-Ser328 (IL12B/P40)/Arg23-Ser219(P35/IL12A)

    Involved Pathway

    IL12 involved in several pathways and played different roles in them. We selected most pathways IL12 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction SSTR2,GCGR,P2RY2,CGNRH-R,MTNR1BB,CALCR,NPY6R,LPAR3,GRIA3B,TAAR12H

    Protein Function

    IL12 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by IL12 itself. We selected most functions IL12 had, and list some proteins which have the same functions with IL12. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    IL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12.

    IL12 Related Signal Pathway

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    IL-12 Family Ligands
    MDSC Cytokines and Growth Factors

    References

    • Shanmugam, A; Wang, J; et al. Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1 gamma, MIP2, MIP3 alpha, and IL12 (p40/p70) by retinal Muller glial cells. JOURNAL OF NEUROCHEMISTRY 132:546-558(2015).
    • Braun, J; Kiltz, U; et al. Emerging drugs for the treatment of axial and peripheral spondyloarthritis. EXPERT OPINION ON EMERGING DRUGS 20:1-14(2015).

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