IL12

  • Official Full Name

    Interleukin 12

  • Overview

    Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.
  • Synonyms

    Il12a; interleukin 12a; p35; Ll12a; Il-12a; IL-12p35; MGC151228; MGC151232; interleukin 12a p35 subunit; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); P35; CLMF; NFSK; NKSF1; IL-12A; natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation factor 1, p35; interleukin;

  • Recombinant Proteins
  • GMP Proteins
  • Transfected Stable Cell Lines
  • Human
  • Mouse
  • Rat
  • CHO
  • CHO-K1
  • HEK293
  • HEK293 cells
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Strep
  • Fc
  • Fc|His
  • Avi
  • HlgG1 Fc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL12-002H Active Recombinant Human IL12, HIgG1 Fc-tagged, mutant CHO Fc
Human IL12-001H Active Recombinant Human IL12, HIgG1 Fc-tagged CHO Fc
Human IL12-160HG Active GMP Recombinant Human IL12 Protein HEK293
Human IL12-01HG Active GMP Recombinant Human IL12 Protein CHO-K1
Human IL12-4327H Recombinant Human IL12A&IL12B heterodimer protein CHO N/A
Human p40-P1008H Recombinant Human IL-12/23 p40, Fc/His-tagged CHO Fc/His
Human IL12-159HB Recombinant Human IL12 protein, His-tagged, Biotinylated HEK293 His
Human IL12-158HG Active GMP Recombinant Human IL12 Protein HEK293 N/A
Human IL12-3720H Recombinant Human IL12 Protein (Arg23-Ser219, Ile23-Ser328), C-His and Strep tagged Mammalian cells C-His and Strep Arg23-Ser219, Ile23-Ser328
Human IL12-146H Human Interleukin-12 (rDNA derived) Reference standard N/A
Human IL12-159H Active Recombinant Human IL12 protein, His-tagged HEK293 His IL12A: Met 1-Ser 219 <br />IL12B: Met 1-Ser 328
Human IL12-158H Recombinant Human IL12 Protein HEK293 N/A Arg23-Ser219&Ile23-Ser328
Human IL12-47H Recombinant Human IL12 p40 (Ile23-Ser328) and p35 (Arg23-Ser219) Protein Insect cells p40 (Ile23-Ser328) and p35 (Arg23-Ser219)
Human IL12-159HG Active GMP Recombinant Human IL12 protein HEK293 DNA sequence encoding Human p35 Subunit(UniProtKB/Swiss-Prot: P29459.2),p40 Subunit (NP_002178.2) was expressed with His tag at the C-terminal.
Human IL12-433H Recombinant Human IL12 Protein, His-Avi-tagged HEK293 His-Avi Ile23-Ser328 (IL12B/P40)/Arg23-Ser219(P35/IL12A)
Human IL12-22H Active Recombinant Cynomolgus Monkey IL-12p40 (Ile23-Ser328) and IL-12p35 (Arg57-Ser253) Protein HEK293 IL-12p40 (Ile23-Ser328) and IL-12p35 (Arg57-Ser253)
Human IL12-0097H Recombinant Human IL12 Protein HEK293 cells
Human IL12-12H Recombinant Human IL12 Protein, His-tagged HEK293 His
Mouse IL12B&IL12A-004H Active Recombinant Human IL12B&IL12A, HIgG1 Fc-tagged CHO Fc
Mouse IL12-28M Active Recombinant Mouse IL12 protein, His-tagged Mammalian Cell His
Mouse IL12-002M Active Recombinant Mouse IL12, HIgG1 Fc-tagged CHO Fc
Mouse IL12-001M Active Recombinant Mouse IL12, HIgG1 Fc-tagged, mutant CHO Fc
Mouse Il12-329M Recombinant Mouse Il12, Fc-tagged CHO Fc
Mouse IL12-1031M Active Recombinant Mouse IL12A & IL12B Heterotrimer Protein (Met1-Ala215 & Met1-Ser335), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Ala215 & Met1-Ser335
Mouse Il12-3765M Recombinant Mouse Il12 Protein (Arg23-Ala215, Met23-Ser335), C-His and Strep tagged Mammalian cells C-His and Strep Arg23-Ala215, Met23-Ser335
Rat IL12-27R Active Recombinant Rat IL12 protein, His-tagged Mammalian Cell His
Rat IL12-26R Recombinant Rat IL12 protein, His-tagged Mammalian Cell His
Rat Il12-258I Active Recombinant Rat Il12 Protein, His-tagged CHO His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL12 Related Signal Pathway

IL12 involved in several pathways and played different roles in them. We selected most pathways IL12 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionCHRM5A;VIPR1B;NPY7R;PRLHR;CALCRL;CNR2;TAAR12G;S1PR5;GALR1

IL12 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by IL12 itself. We selected most functions IL12 had, and list some proteins which have the same functions with IL12. You can find most of the proteins on our site.

Function Related Protein

IL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12.

Gene Family

IL

Research Area

Related articles

Shanmugam, A; Wang, J; et al. Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1 gamma, MIP2, MIP3 alpha, and IL12 (p40/p70) by retinal Muller glial cells. JOURNAL OF NEUROCHEMISTRY 132:546-558(2015).
Braun, J; Kiltz, U; et al. Emerging drugs for the treatment of axial and peripheral spondyloarthritis. EXPERT OPINION ON EMERGING DRUGS 20:1-14(2015).
  • Q&As
  • Reviews

Q&As (10)

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How does fluorescence microscopy track IL12 internalization and intracellular trafficking? 11/21/2022

Fluorescence microscopy tracks IL12 internalization and trafficking.

What techniques dissect IL12's signaling cascades and crosstalk with other cytokines? 11/13/2022

Phosphoproteomics and flow cytometry dissect IL12's signaling and crosstalk.

What strategies assess IL12's polarization of T cell subsets and cytokine profiles? 01/30/2022

Flow cytometry and ELISA assess IL12's T cell subset polarization and cytokine profiles.

How are reporter gene assays tailored to study IL12's promoter activity and response elements? 01/27/2022

Reporter gene assays analyze IL12's promoter activity and response elements.

What insights into IL12's cellular distribution and dynamics do super-resolution imaging methods provide? 09/02/2021

Super-resolution imaging details IL12's cellular distribution and dynamics.

What are the benefits of using 3D cell culture models to investigate IL12's effects on tissue microenvironments? 03/31/2021

3D cell culture models reveal IL12's effects on tissue microenvironments.

How do protein-protein interaction assays decipher IL12's binding partners in cellular context? 02/22/2021

Co-localization studies and co-IP assays identify IL12's binding partners.

What methods elucidate IL12's receptor complex formation and stoichiometry? 12/18/2020

Techniques like co-immunoprecipitation reveal IL12 receptor complex assembly.

Can you elaborate on the utility of ChIP-seq in understanding IL12-regulated gene expression networks? 10/10/2020

ChIP-seq helps map IL12-induced gene expression patterns and regulatory regions.

Could you explain how transgenic models help dissect IL12's roles in immune response modulation? 03/19/2020

Transgenic models elucidate IL12's roles in immune response regulation.

Customer Reviews (3)

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Reviews
01/07/2022

    Effective in Th1 cell differentiation.

    04/09/2020

      High specificity in ELISA.

      08/02/2018

        Stable under storage.

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