Active Recombinant Human CCL21 Protein

Cat.No. : CCL21-0625H
Product Overview : Human CCL21 (O00585, 1 a.a. - 134 a.a.) full-length recombinant protein. expressed in Escherichia coli.
  • Specification
  • Gene Information
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Description : This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
Source : E. coli
Species : Human
Form : Lyophlized
Bio-activity : Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/mL.
Molecular Mass : 12 kDa
AA Sequence : MAQSLALSLLILVLAFGIPRTQGSD GGAQDCCLKYSQRKIPAKVVRSYRK QEPSLGCSIPAILFLPRKRSQAELC ADPKELWVQQLMQHLDKTPSPQKPA QGCRKDRGASKTGKKGKGSKGCKRT ERSQTPKGP
Endotoxin : < 0.1 ng/μg (1 EU/μg)
Purity : > 90% by SDS-PAGE and HPLC
Applications : Functional Study
SDS-PAGE
Storage : Store at -20 centigrade on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4 centigrade for 1 month or store at -20 centigrade for 6 months. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : Lyophlized from 2.5% glycine, 0.5% sucrose, 0.01% Tween 80, 5 mM Glutamic acid, pH 4.5
Gene Name : CCL21 chemokine (C-C motif) ligand 21 [ Homo sapiens ]
Official Symbol : CCL21
Synonyms : CCL21; chemokine (C-C motif) ligand 21; SCYA21, small inducible cytokine subfamily A (Cys Cys), member 21; C-C motif chemokine 21; 6Ckine; beta chemokine exodus 2; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; exodus 2; secondary lymphoid tissue chemokine; SLC; TCA4; exodus-2; beta chemokine exodus-2; beta-chemokine exodus-2; small-inducible cytokine A21; secondary lymphoid-tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21; SCYA21; MGC34555;
Gene ID : 6366
mRNA Refseq : NM_002989
Protein Refseq : NP_002980
MIM : 602737
UniProt ID : O00585

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does CCL21 have relationships with other genes or proteins? 02/18/2022

This has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.

What are the applications of CCL21 in medical treatment? 02/27/2021

It can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting CCL21, such as targeted therapies or modulating its expression, are also being investigated.

What diseases can CCL21 deficiency or aberrant expression cause? 02/02/2021

CCL21 deficiency or aberrant expression may be associated with some autoimmune diseases, cancer, and neurodegenerative diseases.

Might abnormal CCL21 levels be indicative of disease? 12/26/2020

Abnormal levels of CCL21 may suggest autoimmune diseases, cancer, and neurodegenerative diseases, but they may also be associated with other diseases.

How to study the regulatory mechanism of CCL21? 10/01/2020

Studying the regulatory mechanism of CCL21 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

How are mutations in CCL21 detected and analyzed? 03/06/2020

Mutations in CCL21 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

Customer Reviews (3)

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Reviews
11/21/2022

    CCL21 products are reliable and stable, and are widely used in scientific research, industrial production and medical fields.

    04/10/2022

      CCL21 has a long half-life and can maintain stability and reliability during the experiment.

      06/28/2021

        When using CCL21 protein for experiments, it can meet specific experimental requirements and research purposes.

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