Active Recombinant human CD4 protein (26-390aa), C-hIgG/His-tagged

Cat.No. : CD4-39H
Product Overview : Recombinant human CD4 protein (26-390aa), fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
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Description : This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Source : HEK293
Species : Human
Tag : C-hIgG-His
Form : Liquid
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of HeLa human cervical epithelial carcinoma cells. When cells are added to human CD4 coated plates. The ED50 range ≤ 10 μg/mL.
Molecular Mass : 67.7kDa (604aa)
Protein Length : 26-390
AA Sequence : KKVVLGKKGDTVELTCTASQKKSIQ FHWKNSNQIKILGNQGSFLTKGPSK LNDRADSRRSLWDQGNFPLIIKNLK IEDSDTYICEVEDQKEEVQLLVFGL TANSDTHLLQGQSLTLTLESPPGSS PSVQCRSPRGKNIQGGKTLSVSQLE LQDSGTWTCTVLQNQKKVEFKIDIV VLAFQKASSIVYKKEGEQVEFSFPL AFTVEKLTGSGELWWQAERASSSKS WITFDLKNKEVSVKRVTQDPKLQMG KKLPLHLTLPQALPQYAGSGNLTLA LEAKTGKLHQEVNLVVMRATQLQKN LTCEVWGPTSPKLMLSLKLENKEAK VSKREKAVWVLNPEAGMWQCLLSDS GQVLLESNIKVLPTW
Endotoxin : <1.0 EU/μg of the protein by the LAL method.
Purity : 90% by SDS-PAGE
Applications : SDS-PAGE, Bioactivity
Storage : Can be stored at +2 o +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL (determined by Absorbance at 280nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 40% glycerol
SDS-PAGE:
Gene Name : CD4 CD4 molecule [ Homo sapiens (human) ]
Official Symbol : CD4
Synonyms : CD4; CD4 molecule; CD4 antigen (p55) , T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut
Gene ID : 920
mRNA Refseq : NM_000616
Protein Refseq : NP_000607
MIM : 186940
UniProt ID : P01730

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (3)

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What is the connection between CD4 and glycoprotein GP120? 11/09/2022

CD4 binds to glycoprotein GP120.

Where is CD4 primarily expressed? 02/26/2022

CD4 is mainly expressed in T cells and thymocytes.

Where is CD4 localized? 03/14/2021

CD4 is localized in the cell membrane.

Customer Reviews (3)

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Reviews
01/08/2031

    The CD4 proteins purchased from your company is suitable for ELISA.

    02/06/2023

      Protein products are put into experiments with good effect and reliable experimental results.

      01/22/2022

        The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

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