Active Recombinant Human CD4 Protein, His-tagged

• Cat.No.: CD4-58H
• Product Overview: CD4 dimer contains CD4 extracellular 4-domains with a homodimer motif and a His tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 26-396 aa
• Description: CD4 is type 1 integral membrane glycoprotein protein on a T cell surface, also known as known as T-cell surface antigen T4/Leu-3. CD4 contains an extracellular domain, a transmembrane domain and a cytoplasmic domain. The extracellular domain has 4 immunoglobulin-like (Ig-like) domains: one Ig-like V-type domain and three Ig-like C2-type domains. The CD4 extracellular domain is responsible for MHC class-II antigen/T-cell receptor interaction and T cell activation. CD4 is also known as interleukin 16 receptor (IL16R). The IL16 cytokine binds CD4 to activate a downstream signalling cascade. CD4 is also the primary receptor for the human immunodeficiency virus (HIV) envelope glycoprotein gp120 to mediate HIV infection and entry into host T cells, as the underlying cause of acquired immune deficiency syndrome (AIDS).
• Molecular Mass: 112 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: >90% dimer form as determined by SDS-PAGE non-reducing conditions
• Application: Verified Applications: ELISA for antibody binding and gp120 binding. Suggested Applications: SPR binding measurements, B cell sorting, immunogen for animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.2μm filtered PBS, pH 7.4, no preservatives
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: CD4 CD4 molecule [Homo sapiens (human)]
• Official Symbol 2: CD4
• Synonyms 2: CD4; CD4 molecule; CD4 antigen (p55), T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut
• Gene ID 2: 920
• mRNA Refseq 2: NM_000616
• Protein Refseq 2: NP_000607
• MIM 2: 186940
• UniProt ID 2: A0A4Y5UGE4