CD4
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Official Full Name
CD4 molecule
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Overview
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] -
Synonyms
CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3;
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- Involved Pathway
- Protein Function
- Interacting Protein
- CD4 Related Articles
- CD4 Related Gene Family
- CD4 Related Research Area
CD4 involved in several pathways and played different roles in them. We selected most pathways CD4 participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell adhesion molecules (CAMs) | BLB2;CLDN8;SDC1;CNTN2;CLDN5;CLDN20;CNTN1;BMA2;ALCAM |
Antigen processing and presentation | HLA-DRB1;B2M;HSPA8;HLA-DPB1;CD4;IFNG;H2-AB1;HLA-B;PSME2 |
Hematopoietic cell lineage | IL11RA;CD36;MME;GM2002;CD1D2;IL3RA;HLA-DRA;FCGR1;IL4 |
T cell receptor signaling pathway | VAV1;MAP2K7;CD3G;IFNG;RHOA;ICOS;HRAS;CARD11;DBNLB |
Primary i | IGLL1;ZAP70;CD40LG;CD40;RAG2;IL7R;Cd79a, Cd79b;CD3D;DCLRE1C |
nodeficiency | TAP2;DCLRE1C;BLNK;IL7R;IL2RG;RFXAP;TNFRSF13B;CD8B1;IKBKG |
CD4 has several biochemical functions, for example, MHC class II protein binding, coreceptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD4 itself. We selected most functions CD4 had, and list some proteins which have the same functions with CD4. You can find most of the proteins on our site.
Function | Related Protein |
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MHC class II protein binding | CD74;CD74A;CD74B;LAG3;KRT17;MARCH8;CD4 |
coreceptor activity | CXCR4;CXCR7B;RAMP1;CCR8;CD86;RGMB;CD4;PVRL2;HFE2 |
enzyme binding | EGLN1;EGFR;PLCB1;CFTR;TAL1;CRB2;TSPAN33;ZNF346;MAPK8 |
extracellular matrix structural constituent | IMPG1;COL11A1B;ACAN;COL24A1;COL4A5;COL27A1B;FBN1;COL1A1B;IMPG2 |
glycoprotein binding | Serpina1c;Itgam&Itgb2;CD4;CDH1;PIP;BBC3;FBXO17;LMAN2;AZGP1 |
protein binding | PGM2;LIPE;ZNF821;MAGEA2;TFAP4;ATP6V1E1;MLLT3;GMDS;ZBTB44 |
protein homodimerization activity | PSMD7;TESCA;DMRTC2;VIL1;MID2;NRF1;BIRC5;PVRL1B;ABP1 |
protein kinase binding | IKBKB;TRIM6;NIPAL1;WAS;H2AFY;NME2;BCL10;TNNI3;AURKA |
receptor activity | NR2C2;VMN1R50;PAQR4;CD33;Siglece;LRRN2;VMN1R41;SEC63;RNF139 |
transmembrane signaling receptor activity | CD300C;FZD1;Cd79a, Cd79b;CALCRLA;MRC1;NRXN3;OR12D2;GPR133;LGR4 |
virus receptor activity | HLA-DRB1;ITGB7;NPC1;F11R;ITGB5;ITGB6;HSPA1B;IDE;CD80 |
zinc ion binding | CXXC5;PGR;TRIM28;BTR06;PIAS4;PPARG;ZNRD1;RNF14;ERI2 |
CD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD4.
LCK; CCR5; vpu; vpu; vpu; H2-Aa; trfe_chick; NR3C1; H2-Ab1; tip_shv2c; ACTB; vpu; HRD3; INPPL1
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Q&As (3)
Ask a questionCD4 binds to glycoprotein GP120.
CD4 is mainly expressed in T cells and thymocytes.
CD4 is localized in the cell membrane.
Customer Reviews (3)
Write a reviewThe CD4 proteins purchased from your company is suitable for ELISA.
Protein products are put into experiments with good effect and reliable experimental results.
The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.
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