CD4

  • Official Full Name

    CD4 molecule

  • Overview

    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
  • Synonyms

    CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Chromatography Reagents
  • Therapeutic Proteins
  • Others
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Hybridoma
  • Bovine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Cynomolgus Monkey
  • Feline
  • Ferret
  • Homo sapiens (Human)
  • Human
  • Macaca Fascicularis
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Macaca fuscata fuscata (Japanese macaque)
  • Macaca mulatta (Rhesus macaque)
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • Rhesus monkey
  • Sheep
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Pneumonas aeruginosa exotoxin A
  • Rabbit
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • Avi|Fc
  • C
  • hIgG
  • His
  • Avi
  • DDDDK
  • DYKDDDDK
  • Fc
  • Fc|His
  • Flag
  • GST
  • hFc
  • His (Fc)
  • His|Avi
  • His|GST
  • His|S
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD4-39H Active Recombinant human CD4 protein (26-390aa), C-hIgG/His-tagged HEK293 C-hIgG-His 26-390
Human CD4-3167H Active Recombinant Human CD4 protein, His-tagged HEK293 His Lys26-Trp390
Human CD4-016H Active Recombinant Human CD4 protein, hFc-tagged HEK293 hFc Met1-Trp390
Human CD4-102H Recombinant Human CD4 Molecule, His-tagged(203-317aa) E.coli N/A
Human CD4-27808TH Recombinant Human CD4 E.coli N/A
Human CD4-2219H Recombinant Human CD4, Fc-His tagged Human Cell Fc/His
Human CD4-104H Recombinant Human CD4 Molecule (411-459) E.coli N/A
Human CD4-234H Recombinant Human CD4, StrepII-tagged Human Cell Strep II 26-396, 371 a.a.
Human CD4-26367TH Recombinant Human CD4 Sf9 Insect Cell N/A 365 amino acids
Human CD4-10954H Recombinant Human CD4, GST-tagged E.coli GST 419-458a.a.
Human CD4-103H Recombinant Human CD4 Molecule(26-226aa) E.coli N/A
Human CD4-99H Recombinant Human Soluble CD4 Molecule Insect Cell N/A
Human CD4-101H Recombinant Human CD4 Molecule, His-tagged (125-202aa) E.coli N/A
Human CD4-3836H Active Recombinant Human CD4 protein, His-tagged HEK293 His Met1-Ser208
Human CD4-19H Recombinant Human CD4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD4-27809TH Recombinant Human CD4 E.coli N/A
Human CD4-0807H Recombinant Human CD4 Protein, GST-Tagged Wheat Germ GST
Human CD4-1559H Recombinant Human CD4 protein, His-tagged E.coli His Lys26~Trp390
Human CD4-0806H Recombinant Human CD4 Protein Wheat Germ N/A
Human CD4-1905HCL Recombinant Human CD4 cell lysate Human Cell N/A
Human CD4-2864H Recombinant Human CD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD4-5367H Recombinant Human CD4 protein, His-tagged Yeast His 26-396aa
Human CD4-4658H Active Recombinant Human CD4 Protein, His-tagged, PE-Labeled HEK293 His Lys 26 - Pro 396
Human CD4-156H Recombinant Human CD4 Protein, His-tagged HEK293 His 458
Human CD4-172H Recombinant Human CD4 Protein, C-His-tagged E.coli C-His
Human CABTT-005RH Rabbit Anti-Human CD4 Monoclonal Antibody Rabbit N/A
Human CD4-6234M CD4 protein-coupled magnetic NanoBeads(GMP)
Human CD4-23H Recombinant Human CD4 Protein, Fc & Avi-tagged HEK293 Avi/Fc
Human CD4-4064M CD4 protein-coupled magnetic MicroBeads
Human CD4-P022H Recombinant Human CD4 therapeutic protein Pneumonas aeruginosa exotoxin A N/A
Human CD4-2172H Active Recombinant Human CD4 protein, His-tagged HEK293 His Met1-Trp390
Human CD4-24H Recombinant Human CD4 Protein, His & Avi-tagged HEK293 His/Avi
Human CD4-5031M CD4 protein-coupled magnetic NanoBeads
Human CD4-475M CD4 protein-coupled magnetic MicroBeads
Human CD4-3913M Leukopak CD4 protein-coupled magnetic MicroBeads
Human CD4-313H Active Recombinant Human CD4 Protein (Lys 26 - Pro 396), His & Avi-tagged, Biotinylated HEK293 His/Avi Lys 26 - Pro 396
Human CD4-5032M CD4 protein-coupled magnetic NanoBeads
Human CD4-6235M CD4 protein-coupled magnetic NanoBeads(GMP)
Human CD4-048H Recombinant Human CD4 Protein, Lys26-Trp390, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Lys26-Trp390
Human CD4-314H Active Recombinant Human CD4 Protein (Lys 26 - Pro 396), Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc Lys 26 - Pro 396
Human CD4-8765M Whole Blood CD4 protein-coupled magnetic MicroBeads
Human CD4-151H Recombinant Human CD4 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human CDA078P Recombinant Human CD-4 E.coli N/A
Human CD4-2360H Recombinant Human CD4 protein, His-tagged E.coli His 26–396aa
Human CD4-9310M LRSC CD4 protein-coupled magnetic MicroBeads
Human CD4-052H Active Recombinant Human CD4 Protein, Fc-tagged HEK293 Fc Lys26-Gln390
Human CD4-293H Recombinant Human CD4 protein, His-Avi-tagged HEK293 His-Avi It contains Glu21-Arg193.
Human CD4-327H Active Recombinant Human CD4 protein, His-tagged HEK293 His Lys26-Gln390
Human CD4-8919HFL Recombinant Full Length Human CD4 protein, Flag-tagged Mamanlian cells Flag
Human CD4-1460H Recombinant Human CD4 Protein (Lys26-Trp390), His tagged E.coli His Lys26-Trp390
Human CD4-3182HF Recombinant Full Length Human CD4 Protein In Vitro Cell Free System 288 amino acids
Human CD4-017H Active Recombinant Human CD4 protein (Lys26-Pro396), hFc-tagged, FITC-Labeled HEK293 hFc Lys 26 - Pro 396
Human CD4-3184HF Recombinant Full Length Human CD4 Protein, GST-tagged In Vitro Cell Free System GST 458 amino acids
Human CD4-5293H Recombinant Human CD4 Protein (Met1-Trp390), C-His tagged Mammalian cells C-His Met1-Trp390
Human CD4-2616H Active Recombinant Human CD4 protein, His-tagged HEK293 His Lys26-Trp390
Human CD4-4832M Buffy Coat CD4 protein-coupled magnetic MicroBeads
Human CD4-3921M Buffy Coat REAlease CD4 protein-coupled magnetic MicroBeads
Mouse Cd4-1560M Recombinant Mouse Cd4 protein, His-tagged E.coli His Lys27~Thr394
Mouse Cd4-2276M Active Recombinant Mouse Cd4 protein(Met1-Thr394), His-tagged HEK293 C-His Met1-Thr394
Mouse CD4-2580MCL Recombinant Mouse CD4 cell lysate Human Cell N/A
Mouse CD4-3024M Spleen CD4 protein-coupled magnetic MicroBeads
Mouse Cd4-841M Recombinant Mouse Cd4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd4-160MG GMP Recombinant Mouse Cd4 protein HEK293 DNA sequence encoding Mouse CD4(UniProtKB/Swiss-Prot: P06332) was expressed with His tag at the C-terminal.
Mouse CD4-321M Recombinant Mouse CD4 protein, Fc-tagged HEK293 Fc Thr27-Thr394
Mouse CD4-803M Recombinant Mouse CD4 Protein (Met1-Thr394), His-tagged, Biotinylated HEK293 His Met1-Thr394
Rat CD4-1075R Active Recombinant Rat CD4 protein, His-tagged HEK293 His Met1-Thr394
Rat CD4-1252R Recombinant Rat CD4 Protein Mammalian Cell His
Rat CD4-910R-B Recombinant Rat CD4 Protein Pre-coupled Magnetic Beads HEK293
Rat CD4-218M CD4 protein-coupled magnetic MicroBeads
Rat CD4-910R Recombinant Rat CD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Monkey CD4-0809M Recombinant Monkey CD4 Protein, His-Tagged HEK293 His
Rhesus monkey CD4-1562R Recombinant Rhesus monkey CD4 protein, His & S-tagged E.coli His/S Lys26~Pro396 (Accession # P16003)
Rabbit CD4-1561R Recombinant Rabbit CD4 protein, His & GST-tagged E.coli His/GST Val29~Pro396 (Accession # P46630)
Bovine CSC-H0173 Mouse Anti-Bovine CD4 Hybridoma N/A
Canis lupus familiaris (Dog) (Canis familiaris) RFL1835CF Recombinant Full Length Dog T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-463)
Cynomolgus Monkey CD4-143C Recombinant Cynomolgus CD4, His tagged Human Cell DDDDK
Cynomolgus Monkey CD4-947CCL Recombinant Cynomolgus CD4 cell lysate Human Cell N/A
Feline CD4-634F Active Recombinant Feline CD4, His-tagged Mammalian cells His
Feline CD4-3F-B Recombinant Feline CD4 Protein Pre-coupled Magnetic Beads HEK293
Feline CD4-3F Recombinant Feline CD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Ferret CD4-1023F Active Recombinant Ferret CD4 Protein, His-tagged HEK293 His
Ferret CD4-1865FCL Recombinant Ferret CD4 cell lysate Human Cell N/A
Homo sapiens (Human) RFL19470HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-458)
Macaca Fascicularis CD4-01H Recombinant Cynomolgus CD4, His tagged HEK293 His 373
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL19827MF Recombinant Full Length Macaca Fascicularis T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-458)
Macaca fuscata fuscata (Japanese macaque) RFL28296MF Recombinant Full Length Macaca Fuscata Fuscata T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-458)
Macaca mulatta (Rhesus macaque) RFL26087MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-458)
Mus musculus (Mouse) RFL27806MF Recombinant Full Length Mouse T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-457)
Oryctolagus cuniculus (Rabbit) RFL13540OF Recombinant Full Length Rabbit T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-459)
Pan troglodytes (Chimpanzee) RFL14233PF Recombinant Full Length Pan Troglodytes T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-458)
Rattus norvegicus (Rat) RFL13750RF Recombinant Full Length Rat T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-457)
Rhesus CD4-169C Active Recombinant Rhesus CD4 protein, His-tagged HEK293 His
Rhesus CD4-739R Active Recombinant Rhesus CD4 protein(Met1-Trp390), His-tagged HEK293 C-His Met1-Trp390
Rhesus macaque CD4-740R Recombinant Rhesus macaque CD4 protein, Fc-tagged HEK293 human/IgG1/Fc Lys26-Trp390
Rhesus macaque CD4-377R Active Recombinant Rhesus macaque CD4 protein, His-tagged HEK293 His Lys26-Trp390
Rhesus macaque CD4-158R Recombinant Rhesus macaque CD4 Protein, His-tagged HEK293 His 458
Rhesus Macaque CD4-565R Recombinant Rhesus Macaque CD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CD4-565R-B Recombinant Rhesus Macaque CD4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus macaque CD4-159R Recombinant Rhesus macaque CD4 Protein, Fc-tagged HEK293 Fc 458
Sheep CSC-H0008 Mouse Anti-Sheep CD4 Hybridoma N/A
Zebrafish CD4-7178Z Recombinant Zebrafish CD4 Mammalian Cell His
Chicken CD4-6217C Recombinant Chicken CD4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD4 involved in several pathways and played different roles in them. We selected most pathways CD4 participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)NADL1.2;ITGA6;HLA-DMB;CLDNB;MHC2DEB;OCLN;ITGB1B.2;SELE;CLDN10A
Antigen processing and presentationCD8B1;PDIA3;RFXAP;HSPA6;HLA-G;H2-Q10;HSPA5;CTSB;TAP1
Hematopoietic cell lineageItgam&Itgb2;CD4;FCGR1A;IL11RA2;IL1R1;CD8B1;ITGA3;CD1E, B2M;CD1D
T cell receptor signaling pathwayCD4;CD28;EVLB;KRAS;NFATC3;PTPRC;PAK6;NCK2;IKBKG
Primary iCD8A;TAP1;CD8B;IL7R;RFXAP;ORAI1;CD8B1;UNG;ZAP70
nodeficiencyCD40LG;TAP2;ICOS;TAP1;ZAP70;CD79A;RFXAP;IGLL1;CD8B1

CD4 has several biochemical functions, for example, MHC class II protein binding, coreceptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD4 itself. We selected most functions CD4 had, and list some proteins which have the same functions with CD4. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein bindingCD74B;CD4;CD74;KRT17;LAG3;CD74A;MARCH8
coreceptor activityCXCR7B;RAMP3;ACVR2A;NRP1;TGFBR3;CD8A;PVRL2;CXCR4;LY96
enzyme bindingHIST1H2AD;UGT1A4;RFC5;PUS7;PRTN3;HLCS;ATP2A2;PHKG1;TSPAN10
extracellular matrix structural constituentLAMA4;MFAP5;BGN;COL4A5;COL5A2;LAMA1;FBLN2;COL1A1B;IMPG1
glycoprotein bindingHSPA5;TFR2;SERPINA1;RGMA;LCK;SDC1;PLAT;VLDLR;SERPINA1A
protein bindingMYL7;MAP4K3;HPRT1;DPYD;MRAP2;PRKAB1;USP28;EYA2;ZCCHC8
protein homodimerization activityACAT1;CCBL1;ERCC5;LRRC41;NR2F2;PLDN;GPD1B;CCDC88A;STUB1
protein kinase bindingMLKL;MAML1;DLG1;RELA;GDF3;GSTP2;TMEM173;CDC25C;PPP1CB
receptor activityMED1;MED12;VMN1R46;RAMP3;CD160;CD1D;CD200R4;IL18RAP;THBD
transmembrane signaling receptor activityGLP1R;OR2A4;THBD;TLR5;EMR4;TLR6;MRC1;CLEC1B;CLEC2H
virus receptor activityCR2;CD80;CLDN1;SCARB2;LDLR;TFRC;HAVCR1;CD46;CLEC5A
zinc ion bindingALPP;PGGT1B;PDZRN3B;NEURL3;NRD1B;ZNF184;IFIH1;ADAMTS3;RPH3A

CD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD4.

LCK; CCR5; vpu; vpu; vpu; H2-Aa; trfe_chick; NR3C1; H2-Ab1; tip_shv2c; ACTB; vpu; HRD3; INPPL1

Gene Family

Immunoglobulins

Research Area

Related articles

Chang, B; Sheng, R; et al. Prevalence of Howell-Jolly Body-Like Inclusions in HIV Patients and Their Correlation with CD4 Counts and HIV RNA Viral Load. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:23-26(2015).
Nkala, B; Khunwane, M; et al. Kganya Motsha Adolescent Centre: a model for adolescent friendly HIV management and reproductive health for adolescents in Soweto, South Africa. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 27:697-702(2015).
  • Q&As
  • Reviews

Q&As (3)

Ask a question
What is the connection between CD4 and glycoprotein GP120? 11/09/2022

CD4 binds to glycoprotein GP120.

Where is CD4 primarily expressed? 02/26/2022

CD4 is mainly expressed in T cells and thymocytes.

Where is CD4 localized? 03/14/2021

CD4 is localized in the cell membrane.

Customer Reviews (3)

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Reviews
01/08/2031

    The CD4 proteins purchased from your company is suitable for ELISA.

    02/06/2023

      Protein products are put into experiments with good effect and reliable experimental results.

      01/22/2022

        The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

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