CD4

  • Official Full Name

    CD4 molecule

  • Overview

    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
  • Synonyms

    CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Chromatography Reagents
  • Therapeutic Proteins
  • Others
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Hybridoma
  • Bovine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Cynomolgus Monkey
  • Feline
  • Ferret
  • Homo sapiens (Human)
  • Human
  • Macaca Fascicularis
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Macaca fuscata fuscata (Japanese macaque)
  • Macaca mulatta (Rhesus macaque)
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • Rhesus monkey
  • Sheep
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Pneumonas aeruginosa exotoxin A
  • Rabbit
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • Avi|Fc
  • C
  • hIgG
  • His
  • DDDDK
  • DYKDDDDK
  • Fc
  • Fc|His
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|Avi
  • His|GST
  • His|S
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD4-3167H Active Recombinant Human CD4 protein, His-tagged HEK293 His
Human CD4-016H Active Recombinant Human CD4 protein, hFc-tagged HEK293 hFc
Human CD4-102H Recombinant Human CD4 Molecule, His-tagged(203-317aa) E.coli N/A
Human CD4-27808TH Recombinant Human CD4 E.coli N/A
Human CD4-2219H Recombinant Human CD4, Fc-His tagged Human Cell Fc/His
Human CD4-104H Recombinant Human CD4 Molecule (411-459) E.coli N/A
Human CD4-234H Recombinant Human CD4, StrepII-tagged Human Cell Strep II
Human CD4-26367TH Recombinant Human CD4 Sf9 Insect Cell N/A
Human CD4-10954H Recombinant Human CD4, GST-tagged E.coli GST
Human CD4-103H Recombinant Human CD4 Molecule(26-226aa) E.coli N/A
Human CD4-99H Recombinant Human Soluble CD4 Molecule Insect Cell N/A
Human CD4-101H Recombinant Human CD4 Molecule, His-tagged (125-202aa) E.coli N/A
Human CD4-3836H Active Recombinant Human CD4 protein, His-tagged HEK293 His
Human CD4-19H Recombinant Human CD4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD4-27809TH Recombinant Human CD4 E.coli N/A
Human CD4-0807H Recombinant Human CD4 Protein, GST-Tagged Wheat Germ GST
Human CD4-1559H Recombinant Human CD4 protein, His-tagged E.coli His
Human CD4-0806H Recombinant Human CD4 Protein Wheat Germ N/A
Human CD4-1905HCL Recombinant Human CD4 cell lysate Human Cell N/A
Human CD4-2864H Recombinant Human CD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD4-5367H Recombinant Human CD4 protein, His-tagged Yeast His
Human CD4-4658H Active Recombinant Human CD4 Protein, His-tagged, PE-Labeled HEK293 His
Human CD4-156H Recombinant Human CD4 Protein, His-tagged HEK293 His
Human CD4-172H Recombinant Human CD4 Protein, C-His-tagged E.coli C-His
Human CABTT-005RH Rabbit Anti-Human CD4 Monoclonal Antibody Rabbit N/A
Human CD4-6234M CD4 protein-coupled magnetic NanoBeads(GMP)
Human CD4-23H Recombinant Human CD4 Protein, Fc & Avi-tagged HEK293 Avi/Fc
Human CD4-4064M CD4 protein-coupled magnetic MicroBeads
Human CD4-P022H Recombinant Human CD4 therapeutic protein Pneumonas aeruginosa exotoxin A N/A
Human CD4-2172H Active Recombinant Human CD4 protein, His-tagged HEK293 His
Human CD4-24H Recombinant Human CD4 Protein, His & Avi-tagged HEK293 His/Avi
Human CD4-5031M CD4 protein-coupled magnetic NanoBeads
Human CD4-39H Active Recombinant human CD4 protein (26-390aa), C-hIgG/His-tagged HEK293 C-hIgG-His
Human CD4-3913M Leukopak CD4 protein-coupled magnetic MicroBeads
Human CD4-313H Active Recombinant Human CD4 Protein (Lys 26 - Pro 396), His & Avi-tagged, Biotinylated HEK293 His/Avi
Human CD4-5032M CD4 protein-coupled magnetic NanoBeads
Human CD4-475M CD4 protein-coupled magnetic MicroBeads
Human CDA078P Recombinant Human CD-4 E.coli N/A
Human CD4-314H Active Recombinant Human CD4 Protein (Lys 26 - Pro 396), Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human CD4-8765M Whole Blood CD4 protein-coupled magnetic MicroBeads
Human CD4-6235M CD4 protein-coupled magnetic NanoBeads(GMP)
Human CD4-293H Recombinant Human CD4 protein, His-Avi-tagged HEK293 His-Avi
Human CD4-151H Recombinant Human CD4 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human CD4-9310M LRSC CD4 protein-coupled magnetic MicroBeads
Human CD4-2360H Recombinant Human CD4 protein, His-tagged E.coli His
Human CD4-8919HFL Recombinant Full Length Human CD4 protein, Flag-tagged Mamanlian cells Flag
Human CD4-052H Active Recombinant Human CD4 Protein, Fc-tagged HEK293 Fc
Human CD4-3182HF Recombinant Full Length Human CD4 Protein In Vitro Cell Free System
Human CD4-327H Active Recombinant Human CD4 protein, His-tagged HEK293 His
Human CD4-3184HF Recombinant Full Length Human CD4 Protein, GST-tagged In Vitro Cell Free System GST
Human CD4-1460H Recombinant Human CD4 Protein (Lys26-Trp390), His tagged E.coli His
Human CD4-2616H Active Recombinant Human CD4 protein, His-tagged HEK293 His
Human CD4-017H Active Recombinant Human CD4 protein (Lys26-Pro396), hFc-tagged, FITC-Labeled HEK293 hFc
Human CD4-5293H Recombinant Human CD4 Protein (Met1-Trp390), C-His tagged Mammalian cells C-His
Human CD4-4832M Buffy Coat CD4 protein-coupled magnetic MicroBeads
Human CD4-3921M Buffy Coat REAlease CD4 protein-coupled magnetic MicroBeads
Mouse Cd4-1560M Recombinant Mouse Cd4 protein, His-tagged E.coli His
Mouse Cd4-2276M Active Recombinant Mouse Cd4 protein(Met1-Thr394), His-tagged HEK293 C-His
Mouse CD4-2580MCL Recombinant Mouse CD4 cell lysate Human Cell N/A
Mouse CD4-3024M Spleen CD4 protein-coupled magnetic MicroBeads
Mouse Cd4-841M Recombinant Mouse Cd4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd4-160MG GMP Recombinant Mouse Cd4 protein HEK293
Mouse CD4-321M Recombinant Mouse CD4 protein, Fc-tagged HEK293 Fc
Mouse CD4-803M Recombinant Mouse CD4 Protein (Met1-Thr394), His-tagged, Biotinylated HEK293 His
Rat CD4-1075R Active Recombinant Rat CD4 protein, His-tagged HEK293 His
Rat CD4-1252R Recombinant Rat CD4 Protein Mammalian Cell His
Rat CD4-910R-B Recombinant Rat CD4 Protein Pre-coupled Magnetic Beads HEK293
Rat CD4-218M CD4 protein-coupled magnetic MicroBeads
Rat CD4-910R Recombinant Rat CD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Monkey CD4-0809M Recombinant Monkey CD4 Protein, His-Tagged HEK293 His
Rhesus monkey CD4-1562R Recombinant Rhesus monkey CD4 protein, His & S-tagged E.coli His/S
Rabbit CD4-1561R Recombinant Rabbit CD4 protein, His & GST-tagged E.coli His/GST
Bovine CSC-H0173 Mouse Anti-Bovine CD4 Hybridoma N/A
Canis lupus familiaris (Dog) (Canis familiaris) RFL1835CF Recombinant Full Length Dog T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Cynomolgus Monkey CD4-143C Recombinant Cynomolgus CD4, His tagged Human Cell DDDDK
Cynomolgus Monkey CD4-947CCL Recombinant Cynomolgus CD4 cell lysate Human Cell N/A
Feline CD4-634F Active Recombinant Feline CD4, His-tagged Mammalian cells His
Feline CD4-3F-B Recombinant Feline CD4 Protein Pre-coupled Magnetic Beads HEK293
Feline CD4-3F Recombinant Feline CD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Ferret CD4-1023F Active Recombinant Ferret CD4 Protein, His-tagged HEK293 His
Ferret CD4-1865FCL Recombinant Ferret CD4 cell lysate Human Cell N/A
Homo sapiens (Human) RFL19470HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Macaca Fascicularis CD4-01H Recombinant Cynomolgus CD4, His tagged HEK293 His
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL19827MF Recombinant Full Length Macaca Fascicularis T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Macaca fuscata fuscata (Japanese macaque) RFL28296MF Recombinant Full Length Macaca Fuscata Fuscata T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Macaca mulatta (Rhesus macaque) RFL26087MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL27806MF Recombinant Full Length Mouse T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Oryctolagus cuniculus (Rabbit) RFL13540OF Recombinant Full Length Rabbit T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Pan troglodytes (Chimpanzee) RFL14233PF Recombinant Full Length Pan Troglodytes T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL13750RF Recombinant Full Length Rat T-Cell Surface Glycoprotein Cd4(Cd4) Protein, His-Tagged E.coli expression system His
Rhesus CD4-169C Active Recombinant Rhesus CD4 protein, His-tagged HEK293 His
Rhesus CD4-739R Active Recombinant Rhesus CD4 protein(Met1-Trp390), His-tagged HEK293 C-His
Rhesus macaque CD4-740R Recombinant Rhesus macaque CD4 protein, Fc-tagged HEK293 human/IgG1/Fc
Rhesus macaque CD4-377R Active Recombinant Rhesus macaque CD4 protein, His-tagged HEK293 His
Rhesus macaque CD4-158R Recombinant Rhesus macaque CD4 Protein, His-tagged HEK293 His
Rhesus Macaque CD4-565R Recombinant Rhesus Macaque CD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CD4-565R-B Recombinant Rhesus Macaque CD4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus macaque CD4-159R Recombinant Rhesus macaque CD4 Protein, Fc-tagged HEK293 Fc
Sheep CSC-H0008 Mouse Anti-Sheep CD4 Hybridoma N/A
Zebrafish CD4-7178Z Recombinant Zebrafish CD4 Mammalian Cell His
Chicken CD4-6217C Recombinant Chicken CD4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD4 Related Articles
  • CD4 Related Gene Family
  • CD4 Related Research Area

CD4 involved in several pathways and played different roles in them. We selected most pathways CD4 participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)H2-Q10;PVR;HLA-DRB3;F11R;CLDNG;CLDN17;CLDNK;H2-AB1;ITGB1A
Antigen processing and presentationPSME2;RFXANK;KLRC3;CD8B1;HLA-DMA;CD8A;NFYC;CANX;HLA-DPA1
Hematopoietic cell lineageFCGR1;ITGA3;GYPA;CD1E, B2M;GP1BA;HLA-DRA;KIT;EPOR;IL11RA2
T cell receptor signaling pathwayNFKBIA;RHOA;GRAP2;CABIN1;KRAS;PAK1;TNF;NFATC1;MAPK12
Primary iTNFRSF13B;TAP1;CD4;TAP2;AIRE;CD8B1;CD8A;CD19;PTPRC
nodeficiencyRFXAP;CD8B1;BLNK;CD4;CD3D;CD19;ORAI1;TAP1;CD40LG

CD4 has several biochemical functions, for example, MHC class II protein binding, coreceptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD4 itself. We selected most functions CD4 had, and list some proteins which have the same functions with CD4. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein bindingCD74A;MARCH8;KRT17;CD74;CD74B;CD4;LAG3
coreceptor activityCXCR4;CCR5;CD4;RGMA;RGMB;IGSF1;PVRL1;TGFBR3;ACKR3B
enzyme bindingDAOA;PPP1R3B;PICK1;ATP2A2;PTPLAD2;PARP4;CDK19;SLC12A3;HSPA1A
extracellular matrix structural constituentCOL27A1A;IMPG1;COL3A1;PRELP;FBN1;LUM;CHI3L1;MATN1;OPTC
glycoprotein bindingFOXRED2;ITGB2;BMPR1B;Shh;FYN;LRRK2;LGALS1;AZGP1;LACRT
protein bindingNXT2;MME;MIEF1;CCDC47;STX19;CD22;DAZL;PCSK5;DAO
protein homodimerization activityPVR;YARS2;UGT1A2;BARD1;CHMP3;SPPL2B;PLEKHB1;CHMP1A;DMRT1
protein kinase bindingAKAP7;IRS2;TEX14;SYN1;DUSP3;CAMK2N1A;RPTOR;SQSTM1;CCNL2
receptor activityNLGN4X;NOTCH1A;ATP6AP2;GABRA5;ABP1;CSF3R;CADM1B;NRXN1;ADIPOR1A
transmembrane signaling receptor activityLILRB3;CD69;GABRQ;PTH1RB;ERBB3;Cd79a, Cd79b;DCC;OR4F29;EBP
virus receptor activityLDLR;ANPEP;CD209A;DPP4;EFNB2;GYPA;ITGB1;ITGB3;CLEC5A
zinc ion bindingSPG7;PHC2B;SIAH1;CAR7;ZDHHC24;PHF20B;TRIM13;ZDHHC3A;APOBEC1

CD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD4.

LCK; CCR5; vpu; vpu; vpu; H2-Aa; trfe_chick; NR3C1; H2-Ab1; tip_shv2c; ACTB; vpu; HRD3; INPPL1

Chang, B; Sheng, R; et al. Prevalence of Howell-Jolly Body-Like Inclusions in HIV Patients and Their Correlation with CD4 Counts and HIV RNA Viral Load. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:23-26(2015).
Nkala, B; Khunwane, M; et al. Kganya Motsha Adolescent Centre: a model for adolescent friendly HIV management and reproductive health for adolescents in Soweto, South Africa. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 27:697-702(2015).
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