Active Recombinant Human FLT3LG

Cat.No. : FLT3LG-8901H
Product Overview : Recombinant Human FLT3LG was expressed in CHO Cells.
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Description : Fms-related tyrosine kinase 3 ligand (Flt3L) is growth fator stimulates the proliferation and differentiation of hematopoietic multipotent progenitors and promotes proliferation of NK cells and dendritic cell subgroups by combination with other growth factors. Flt3L is produced by T cells and stromal fibroblasts, and targeted various cells including hematopoietic stem cells, B cells, T cells, dendritic cells, and NK cells. Flt3L binds to it cognate tyrosine kinase receptor Flt3 and activates JAK/STAT signaling pathway[3].Flt3L is a hematopoietic four helical bundle cytokine with structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1) demonstrated four conserved cysteines and two glycosylation sites. Flt3L naturally as a non-disulfide-linked homodimer with multiple isoforms. The extracellular portion is approximately 160 amino acid residues in length and the cytoplasmic segment is approximately 20-30 amino acid residues in length.
Source : CHO Cells
Species : Human
Form : Lyophilized after extensive dialysis against PBS.
Bio-activity : ED50< 1 ng/ml, measured in a cell proliferation assay of human aml5 cells, corresponding to a specific activity of>1 x 106 units/mg
Molecular Mass : Multiple bands between 18~22 kDa, observed by reducing SDS-PAGE.
AA Sequence : Thr27-Pro185
Endotoxin : <0.2 eu/μg, determined by lal>
Purity : >95% as analyzed by SDS-PAGE and HPLC.
Storage : Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFlt-3L should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Reconstitution : Reconstituted in ddH2O or PBS at 100 μg/ml.
Gene Name : FLT3LG fms-related tyrosine kinase 3 ligand [ Homo sapiens ]
Official Symbol : FLT3LG
Synonyms : FLT3LG; fms-related tyrosine kinase 3 ligand; flt3 ligand; FL; FLT3L;
Gene ID : 2323
mRNA Refseq : NM_001204502
Protein Refseq : NP_001191431
MIM : 600007
UniProt ID : P49771
Chromosome Location : 19q13.3
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Pathways in cancer, organism-specific biosystem;
Function : cytokine activity; protein homodimerization activity; receptor binding; receptor tyrosine kinase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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