FLT3LG

  • Official Full Name

    Fms-related tyrosine kinase 3 ligand

  • Overview

    Flt-3 ligand (FL) is a recently identified hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt-3. Flt-3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additional class III RTKs include the receptors from SCF, M-CSF and PDGF. Not surprisingly, Flt-3 ligand is also structurally related to M-CSF and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FL isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FL mRNA, encoding a soluble form of the human FL, has also been identified. FL is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FL are approximately 72% identical and the two proteins exhibit cross-species activity. FL has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors.
  • Synonyms

    Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; Flt3lg; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine; Flt3lg;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Feline
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Porcine
  • Rat
  • Rhesus monkey
  • Baculovirus-Insect cells
  • Barley Grain
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Hordeum Vulgare
  • Human Cell
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Nicotiana Benthamiana
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • mFc
  • 6×His
  • Fc
  • His(C
  • ter)
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FLT3LG-151H Active Recombinant Human FLT3LG Mammalian cells N/A
Human FLT3LG-246H Active Recombinant Human FLT3LG, Fc-tagged CHO Fc
Human FLT3LG-154H Active Recombinant Human FLT3LG Sf9 Insect Cell N/A
Human FLT3LG-276H Active Recombinant Human Fms-related Tyrosine Kinase 3 Ligand, HIgG1 Fc-tagged, mutant CHO Fc
Human FLT3LG-278H Active Recombinant Human Fms-related Tyrosine Kinase 3 Ligand, HIgG1 Fc-tagged CHO Fc
Human FLT3LG-935H Active Recombinant Human Fms-related Tyrosine Kinase 3 Lligand E.coli N/A
Human FLT3LG-275H Active Recombinant Human Fms-related Tyrosine Kinase 3 Ligand, MIgG2a Fc-tagged CHO Fc
Human FLT3LG-152H Active Recombinant Human FLT3LG Sf21 Insect Cell N/A
Human FLT3LG-155H Active Recombinant Human FLT3LG protein Insect Cell N/A Thr27-Pro185
Human FLT3LG-1235H Active Recombinant Human FLT3LG E.coli N/A
Human FLT3LG-25H Active Recombinant Human FLT3L protein Nicotiana Benthamiana N/A
Human FLT3LG-8901H Active Recombinant Human FLT3LG CHO N/A
Human FLT3LG-916HFL Active Recombinant Full Length Human FLT3LG Protein, C-Flag-tagged Mammalian cells Flag
Human FLT3LG-106HG Active GMP Recombinant Human FLT3LG protein E.coli N/A
Human FLT3LG-02H Recombinant Human FLT3LG protein E.coli N/A 155
Human FLT3LG-514H Recombinant Human FLT3LG protein HEK293 159
Human FLT3LG-8532H Recombinant Human FLT3LG protein(Thr27-Pro185), His-tagged Insect Cells N-His Thr27-Pro185
Human FLT3LG-5262H Recombinant Human FLT3LG Protein, GST-tagged Insect Cell GST
Human FLT3LG-28341TH Recombinant Human FLT3LG, His-tagged His
Human FLT3LG-939H Recombinant Human FLT3LG Protein, His-tagged HEK293 His
Human FLT3LG-254H Recombinant Human FLT3LG, StrepII-tagged Human Cell Strep II 27-235, 209 a.a.
Human FLT3LG-5423H Recombinant Human Fms-Related Tyrosine Kinase 3 Ligand, His-tagged Hordeum Vulgare His
Human FLT3LG-28905TH Recombinant Human FLT3LG N/A
Human FLT3LG-001HCL Recombinant Human FLT3LG cell lysate Insect Cell N/A
Human FLT3LG-284F Active Recombinant Human FLT3LG Protein CHO
Human FLT3LG-105HG Active GMP Recombinant Human FLT3LG Protein Insect Cell N/A
Human FLT3LG-4348HG GMP Recombinant Human FLT3LG protein E.coli N/A 155
Human FLT3LG-4374H Active Recombinant Human FLT3LG Protein, His-tagged Barley Grain His
Human FLT3LG-488H Recombinant Human FLT3LG Protein 235
Human FLT3LG-505HG Active GMP Recombinant Human FLT3LG protein HEK293 DNA sequence encoding Human Flt3-Ligand(NP_001450.2) was expressed with His tag at the C-terminal.
Human FLT3LG-4375H Recombinant Human FLT3LG Protein, GST-tagged Wheat Germ GST
Human FLT3LG-2339H Recombinant Human FLT3LG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FLT3LG-312H Recombinant Human FLT3LG protein, His-tagged HEK293 His 159
Human FLT3LG-2924H Recombinant Human FLT3LG protein, His-SUMO-tagged E.coli His-SUMO 27-184aa
Human FLT3LG-366H Active Recombinant Human FLT3 Ligand Protein Human Cells N/A
Human FLT3LG-16H Active Recombinant Human FLT3LG Protein, Animal Free Human cells
Human FLT3LG-764H Recombinant Human FLT3LG protein, hFc-tagged HEK293 hFc It contains Thr 27 - Pro 185.
Human FLT3LG-23H Active Recombinant Human FLT3LG Protein, Pre-aliquoted Insect Cell Thr27-Pro185
Human FLT3LG-001H Recombinant Human FLT3LG Protein, GST-tagged Insect Cell GST
Human FLT3LG-489H Recombinant Human FLT3LG Protein 235
Human FLT3LG-100H Active Recombinant Human FLT3LG Protein E.coli
Human FLT3LG-4965HF Recombinant Full Length Human FLT3LG Protein, GST-tagged In Vitro Cell Free System GST 235 amino acids
Human FLT3LG-156H Recombinant Human FLT3LG protein, C-His-tagged Baculovirus-Insect cells His Thr27-Pro185
Human FLT3LG-925H-B Recombinant Human FLT3LG Protein Pre-coupled Magnetic Beads HEK293
Human FLT3LG-157H Recombinant Human FLT3LG protein, N-His-tagged Baculovirus-Insect cells His Thr27-Pro185
Human FLT3LG-98H Recombinant Active Human FLT3LG Protein, His-tagged(C-ter) E.coli His(C-ter)
Human FLT3LG-3369H Recombinant Human FLT3LG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FLT3LG-719H Active Recombinant Human FLT3LG Protein E.coli Tag Free
Human FLT3LG-1507H Recombinant Human FLT3LG Protein, His&GST-tagged E.coli N-His&GST Met83-Gln183
Human FLT3LG-95H Recombinant Human FLT3LG Protein, His-tagged Human Cell His
Human FLT3LG-597H Recombinant Human FLT3LG Protein (Thr27-Pro185), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His Thr27-Pro185
Human FLT3LG-2914H Recombinant Human FLT3LG Protein (Thr27-Pro184), C-His tagged Mammalian cells C-His Thr27-Pro184
Human FLT3LG-32HG Active Recombinant Human FLT3LG Protein (Thr27-Ala181), GMP Grade, Animal-Free E.coli Thr27-Ala181
Human FLT3LG-4138H Recombinant Human FLT3LG Protein (Ser25-Pro184), C-His tagged Insect Cells C-His Ser25-Pro184
Human FLT3LG-925H Recombinant Human FLT3LG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FLT3LG-110H Active Recombinant Human FLT3LG Protein (Thr27-Ala181), C-His tagged, Animal-free, Carrier-free E.coli C-His Thr27-Ala181
Human FLT3LG-0363H Recombinant Human FLT3LG Protein (Ser25-Pro184), N-His-tagged Baculovirus-Insect cells N-His Ser25-Pro184
Mouse Flt3l-97M Recombinant Mouse FLT3LG Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Met1-Arg188
Mouse Flt3l-96M Recombinant Active Mouse FLT3LG Protein, His-tagged(C-ter) E.coli His(C-ter)
Rat Flt3lg-2189R Recombinant Rat Flt3lg Protein, His-tagged E.coli N-His Thr28-Val218
Rat FLT3LG-973R Recombinant Rat FLT3LG Protein (Thr28-Gln189), His-tagged Insect Cell His Thr28-Gln189
Rhesus monkey FLT3LG-1235R Active Recombinant Rhesus monkey FLT3LG Protein E.coli N/A
Feline FLT3LG-636F Active Recombinant Feline FLT3LG, His-tagged Mammalian cells His
Feline FLT3LG-4F-B Recombinant Feline FLT3LG Protein Pre-coupled Magnetic Beads HEK293
Feline FLT3LG-4F Recombinant Feline FLT3LG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL7140HF Recombinant Full Length Human Fms-Related Tyrosine Kinase 3 Ligand(Flt3Lg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-235)
Mus musculus (Mouse) RFL35157MF Recombinant Full Length Mouse Fms-Related Tyrosine Kinase 3 Ligand(Flt3Lg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-232)
Porcine FLT3LG-01P Active GMP Recombinant Porcine FLT3LG Protein, His-Tagged E.coli His
Pig FLT3LG-04P Active Recombinant Pig FLT3LG Protein (Ser30-Leu205), C-His tagged, Animal-free, Carrier-free E.coli C-His Ser30-Leu205
Pig FLT3LG-100P Recombinant Active Pig FLT3LG Protein, His-tagged(C-ter) E.coli His(C-ter)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FLT3LG involved in several pathways and played different roles in them. We selected most pathways FLT3LG participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3LG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCR1L1;IFNAR2;PF4;LEP;IL10;CCL20B;CSF1RA;GM2002;IL3RA
Hematopoietic cell lineageITGAM;GP1BA;CSF1R;CD9;HLA-DRB1;GM-CSF;GM13305;IL1A;CD59A
Pathways in cancerMSH6;CDH1;PIK3CB;PIK3R5;APC2;CTNNA3;GSTP1;AKT2;ARHGEF12

FLT3LG has several biochemical functions, for example, cytokine activity, protein homodimerization activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3LG itself. We selected most functions FLT3LG had, and list some proteins which have the same functions with FLT3LG. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTGFB1A;IL1A;MSTNB;GDF6;IFNG1-2;GDF2;TNFB;GDF1;CMTM2
protein homodimerization activityCUBN;BLOC1S6;CAMK2B;WRN;BCL2A1A;CD2;PML;VAPB;HARS2
receptor bindingGRIN2A;PPY;FGF6A;SNX17;FGF10A;WNT4A;TGFB2;MCHR1;MAP7
receptor tyrosine kinase bindingDNAJA3;ZNF259;ANGPT2;PTPN1;PITPNM3;Flt3l;MYOC;TP53;FNTA

FLT3LG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3LG here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3LG.

KITLG; PFN2

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