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Official Full Name Fms-related tyrosine kinase 3 ligand
Background Flt-3 ligand (FL) is a recently identified hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt-3. Flt-3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additional class III RTKs include the receptors from SCF, M-CSF and PDGF. Not surprisingly, Flt-3 ligand is also structurally related to M-CSF and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FL isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FL mRNA, encoding a soluble form of the human FL, has also been identified. FL is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FL are approximately 72% identical and the two proteins exhibit cross-species activity. FL has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors.
Synonyms Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; Flt3lg; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine; Flt3lg
    • Species :
    • Feline
    • Human
    • Rat
    • Rhesus monkey
    • Source :
    • Baculovirus-Insect cells
    • Barley Grain
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Hordeum Vulgare
    • Human Cell
    • Human Cells
    • Insect Cell
    • InsectCells-HI5
    • Nicotiana Benthamiana
    • NS0
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • hFc
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FLT3LG-001H Recombinant Human FLT3LG Protein, GST-tagged Insect Cell GST
    Human FLT3LG-001HCL Recombinant Human FLT3LG cell lysate Insect Cell N/A
    Human FLT3LG-02H Recombinant Human FLT3LG protein E.coli N/A
    Human FLT3LG-105HG GMP Recombinant Human FLT3LG Protein Insect Cell N/A
    Human FLT3LG-1235H Recombinant Human FLT3LG E.coli N/A
    Human FLT3LG-151H Recombinant Human FLT3LG NS0 N/A
    Human FLT3LG-152H Recombinant Human FLT3LG Sf21 Insect Cell N/A
    Human FLT3LG-154H Recombinant Human FLT3LG Sf9 Insect Cell N/A
    Human FLT3LG-155H Recombinant Human FLT3LG protein Insect Cell N/A
    Human FLT3LG-156H Recombinant Human FLT3LG protein, C-His-tagged Baculovirus-Insect cells His
    Human FLT3LG-157H Recombinant Human FLT3LG protein, N-His-tagged Baculovirus-Insect cells His
    Human FLT3LG-2339H Recombinant Human FLT3LG Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human FLT3LG-246H Recombinant Human FLT3LG, Fc-tagged CHO Fc
    Human FLT3LG-254H Recombinant Human FLT3LG, StrepII-tagged Human Cell Strep II
    Human FLT3LG-25H Recombinant Human FLT3L protein Nicotiana Benthamiana N/A
    Human FLT3LG-275H Recombinant Human Fms-related Tyrosine Kinase 3 Ligand, MIgG2a Fc-tagged CHO Fc
    Human FLT3LG-276H Recombinant Human Fms-related Tyrosine Kinase 3 Ligand, HIgG1 Fc-tagged, mutant CHO Fc
    Human FLT3LG-278H Recombinant Human Fms-related Tyrosine Kinase 3 Ligand, HIgG1 Fc-tagged CHO Fc
    Human FLT3LG-28341TH Recombinant Human FLT3LG, His-tagged His
    Human FLT3LG-28905TH Recombinant Human FLT3LG N/A
    Human FLT3LG-312H Recombinant Human FLT3LG protein, His-tagged HEK293 His
    Human FLT3LG-3369H Recombinant Human FLT3LG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FLT3LG-366H Recombinant Human FLT3 Ligand Protein Human Cells N/A
    Human FLT3LG-4348HG GMP Recombinant Human FLT3LG protein E.coli N/A
    Human FLT3LG-4374H Recombinant Human FLT3LG Protein, His-tagged Barley Grain His
    Human FLT3LG-4375H Recombinant Human FLT3LG Protein, GST-tagged Wheat Germ GST
    Human FLT3LG-505HG GMP Recombinant Human FLT3LG protein, His-tagged HEK293 His
    Human FLT3LG-514H Recombinant Human FLT3LG protein HEK293
    Human FLT3LG-5262H Recombinant Human FLT3LG Protein, GST-tagged Insect Cell GST
    Human FLT3LG-5423H Recombinant Human Fms-Related Tyrosine Kinase 3 Ligand, His-tagged Hordeum Vulgare His
    Human FLT3LG-764H Recombinant Human FLT3LG protein, hFc-tagged HEK293 hFc
    Human FLT3LG-8532H Recombinant Human FLT3LG protein, His-tagged InsectCells-HI5 His
    Human FLT3LG-8901H Recombinant Human FLT3LG CHO N/A
    Human FLT3LG-935H Recombinant Human Fms-related Tyrosine Kinase 3 Lligand E.coli N/A
    Human FLT3LG-939H Recombinant Human FLT3LG Protein, His-tagged HEK293 His
    Rat FLT3LG-973R Recombinant Rat FLT3LG Protein (Thr28-Gln189), His-tagged Insect Cell His
    Rhesus monkey FLT3LG-1235R Recombinant Rhesus monkey FLT3LG Protein E.coli N/A
    Feline FLT3LG-636F Recombinant Feline FLT3LG, His-tagged NS0 His

    flt3lg involved in several pathways and played different roles in them. We selected most pathways flt3lg participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with flt3lg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CNTF; TNFRSF11A; TNFRSF12A; M17; RNF207B; PLEKHO2; IFNA21; TNFSF13; CXCL12A; IL17RA
    Hematopoietic cell lineage CD1d1; HLA-DRB4; CD1A; CR2; CSF3; Il6ra; TFRC; CD8B; IL9R; Itgam&Itgb2
    Pathways in cancer LAMC2; AGTR1A; AHA-1; SUFU; PRKCG; CCNE2; FGF20; FZD9; ERBB2; FGF8

    flt3lg has several biochemical functions, for example, cytokine activity, protein homodimerization activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by flt3lg itself. We selected most functions flt3lg had, and list some proteins which have the same functions with flt3lg. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity LTB; BMP7; TNFRSF11B; TNFSF11; BMP2B; TNFSF15; GM13285; GDF6B; WNT7A; Ifnz
    protein homodimerization activity SRM; LRRK2; FLNA; SRR; SLC51A; IZUMO1; TFAP4; NTRK2; CRTAM; TRIM37
    receptor binding SLC39A1; TENC1; CAV1; P2RX7; HSPA1B; PVRL2L; SRMS; NRG2; TNFSF14; GLA
    receptor tyrosine kinase binding ZNF259; TP53; NCK1; PIK3R2; ARHGEF16; ANGPT2A; FNTA; PTPN11; ANGPT1; FIZ1

    flt3lg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with flt3lg here. Most of them are supplied by our site. Hope this information will be useful for your research of flt3lg.


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