Active Recombinant Human IL11
Cat.No. : | IL11-325H |
Product Overview : | Human IL11 (P20809) full-elngth recombinant protein expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL11-325H |
Description : | Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene. IL-11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. It is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. Compared to other interleukins, IL-11 relatively under-characterized. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. Signal specificity is provided by the IL-11Ralpha subunit. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. |
Theoretical MW (kDa) : | 19.2 |
Form : | Lyophilized |
Preparation Method : | Escherichia coli expression system |
Purity : | μ 98% by SDS-PAGE , μ 95% by HPLC |
Endotoxin Level : | < 0.2 ng/ug |
Activity : | The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 cells was found to be < 0.2 ng/mL, corresponding to a specific activity of > 8 x 106 units/mg. |
Application : | SDS-PAGE |
Storage : | Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at 4°C for 1 week or store at -20°C for longer. Aliquot to avoid repeated freezing and thawing. |
Unitprot ID : | P20809 |
Pathways : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Gene Name : | IL11 interleukin 11 [ Homo sapiens ] |
Official Symbol : | IL11 |
Synonyms : | AGIF; IL-11; Adipogenesis inhibitory factor, Oprelvekin, Interleukin-11; IL11; interleukin 11 |
Gene ID : | 3589 |
mRNA Refseq : | NM_000641 |
Protein Refseq : | NP_000632 |
MIM : | 147681 |
Chromosome Location : | 19q13.3-q13.4 |
Function : | cytokine activity, interleukin-11 receptor binding activity |
Products Types
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◆ Lysates | ||
IL11-5249HCL | Recombinant Human IL11 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTransgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
Customer Reviews (3)
Write a reviewPotent in bone regeneration models.
Suitable for cell culture.
High yield in expression.
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