Active Recombinant Human IL11

Cat.No. : IL11-325H
Product Overview : Human IL11 (P20809) full-elngth recombinant protein expressed in Escherichia coli.
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Cat. No. : IL11-325H
Description : Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene. IL-11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. It is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. Compared to other interleukins, IL-11 relatively under-characterized. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. Signal specificity is provided by the IL-11Ralpha subunit. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis.
Theoretical MW (kDa) : 19.2
Form : Lyophilized
Preparation Method : Escherichia coli expression system
Purity : μ 98% by SDS-PAGE , μ 95% by HPLC
Endotoxin Level : < 0.2 ng/ug
Activity : The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 cells was found to be < 0.2 ng/mL, corresponding to a specific activity of > 8 x 106 units/mg.
Application : SDS-PAGE
Storage : Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at 4°C for 1 week or store at -20°C for longer. Aliquot to avoid repeated freezing and thawing.
Unitprot ID : P20809
Pathways : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
Gene Name : IL11 interleukin 11 [ Homo sapiens ]
Official Symbol : IL11
Synonyms : AGIF; IL-11; Adipogenesis inhibitory factor, Oprelvekin, Interleukin-11; IL11; interleukin 11
Gene ID : 3589
mRNA Refseq : NM_000641
Protein Refseq : NP_000632
MIM : 147681
Chromosome Location : 19q13.3-q13.4
Function : cytokine activity, interleukin-11 receptor binding activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How are in vivo models, including transgenic mice and knockdown strategies, utilized to study IL11's effects on tissue regeneration and homeostasis? 11/05/2022

Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.

Could you explain the experimental approaches, such as site-directed mutagenesis, employed to identify key residues in IL11's interaction with IL11RA? 07/14/2021

Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.

What techniques like chromatin immunoprecipitation and DNA methylation analysis contribute to deciphering IL11's regulatory mechanisms? 05/27/2021

Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.

Can you elaborate on the role of proteomics in identifying IL11-interacting proteins and potential cross-talk with other signaling pathways? 09/28/2020

Proteomics identifies IL11-interacting proteins and potential cross-talk partners.

How do cell-based assays and luciferase reporter assays help investigate IL11's downstream signaling pathways through JAK-STAT activation? 05/19/2020

Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.

What role does RNA sequencing play in understanding IL11-induced gene expression changes in various cell types? 02/24/2019

RNA sequencing uncovers IL11-induced gene expression changes across different cell types.

What structural insights have X-ray crystallography and nuclear magnetic resonance spectroscopy provided about the IL11-IL11RA complex? 01/13/2019

X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.

How do advanced imaging techniques like confocal microscopy and super-resolution microscopy visualize IL11 localization and distribution in tissues? 11/08/2018

Confocal and super-resolution microscopy visualize IL11 localization in tissues.

How are techniques like surface plasmon resonance used to study IL11's binding kinetics to its receptor IL11RA? 04/17/2017

Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.

What insights have CRISPR screening approaches provided regarding genes and pathways influenced by IL11 signaling? 02/06/2017

CRISPR screening unveils genes and pathways influenced by IL11 signaling.

Customer Reviews (3)

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Reviews
10/28/2019

    Potent in bone regeneration models.

    11/26/2017

      Suitable for cell culture.

      01/10/2017

        High yield in expression.

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