Active Recombinant Human IL21 Protein

• Cat.No.: IL21-866H
• Product Overview: Recombinant Human IL21(Gln32-Ser162), transcript variant 1, was expressed in E. coli.

Specification

• Description: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: E. coli
• Form: 1 x PBS
• Bio-activity: The ED50 is 0.3-0.5 ng/ml, corresponding to a specific activity 2.0-3.3 x 10^6 units/mg determined by a dose-dependent induction of IFNγ secretion by NK-92 cells.
• Molecular Mass: 15.5 kDa
• Purity: >98%, as determined by Coomassie stained SDS-PAGE.
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer

Gene Information

• Gene Name: IL21 interleukin 21 [ Homo sapiens ]
• Official Symbol: IL21
• Synonyms: IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21
• Gene ID: 59067
• mRNA Refseq: NM_001207006
• Protein Refseq: NP_001193935
• MIM: 605384
• UniProt ID: Q9HBE4