Active Recombinant Human JAG1, Fc tagged

Cat.No. : JAG1-3138H
Product Overview : Recombinant Human JAG1 (NP_000205.1) extracellular domain (Met 1-Ser 1046), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cell.
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Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from sterile PBS, pH 7.4
Bio-activity : Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells.
The ED50 for this effect is typically 5-30 μg/mL.
Molecular Mass : The recombinant human JAG1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 1254 amino acids and has a predicted molecular mass of 137 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of human JAG1/Fc monomer is approximately 185.5 kDa due to glycosylation.
Protein Length : Met 1-Ser 1046
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 85 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Publication :
A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells (2019)
Controlled JAGGED1 delivery induces human embryonic palate mesenchymal cells to form osteoblasts (2017)
JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling (2021)
Osteoinductive effect of soluble transforming growth factor beta receptor 3 on human osteoblast lineage (2021)
The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis (2023)
Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects (2023)
Gene Name : JAG1 jagged 1 [ Homo sapiens ]
Official Symbol : JAG1
Synonyms : JAG1; jagged 1; AGS, Alagille syndrome , JAGL1; protein jagged-1; AHD; AWS; CD339; HJ1; AGS; JAGL1; MGC104644;
Gene ID : 182
mRNA Refseq : NM_000214
Protein Refseq : NP_000205
UniProt ID : P78504

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (5)

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How might knowledge of JAG1 protein be applied in the field of regenerative medicine? 12/26/2020

Understanding the role of JAG1 in tissue regeneration and repair may lead to advances in regenerative medicine by promoting controlled cell differentiation.

Are there any clinical tests available for detecting JAG1 mutations in patients? 09/10/2019

Yes, genetic testing can be performed to identify JAG1 mutations in individuals suspected of having Alagille syndrome or related conditions.

Are there any targeted therapies or treatments related to the JAG1 protein for Alagille syndrome? 11/06/2017

Currently, there are no specific targeted therapies for JAG1-related conditions. Treatment typically focuses on managing symptoms and complications.

Are there any clinical trials currently investigating JAG1-related therapies or treatments? 09/05/2017

Some clinical trials may be exploring therapies or treatments related to JAG1 in the context of specific medical conditions, but it's essential to check for the most up-to-date information.

Can JAG1 be a target for cancer therapy? 05/09/2016

Yes, JAG1 is being investigated as a potential target for cancer therapy, as its role in the Notch pathway can influence cell proliferation and tumor growth.

Customer Reviews (3)

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    When used in Western blotting experiments, the JAG1 protein produces distinct protein bands, allowing for easy visualization and interpretation.


      Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.


        JAG1 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

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