Recombinant Mouse Jag1 Protein, Myc/DDK-tagged

• Cat.No.: Jag1-3625M
• Product Overview: Purified recombinant protein of mouse full-length jagged 1 (Jag1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 134.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Jag1 jagged 1 [ Mus musculus (house mouse) ]
• Official Symbol: Jag1
• Synonyms: JAG1; jagged 1; protein jagged-1; Serrate-1; Htu; Ozz; ABE2; Ser-1; Gsfabe2
• Gene ID: 16449
• mRNA Refseq: NM_013822
• Protein Refseq: NP_038850
• UniProt ID: Q9QXX0

Reviews

06/24/2021

When used in Western blotting experiments, the JAG1 protein produces distinct protein bands, allowing for easy visualization and interpretation.

08/29/2020

Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.

04/04/2016

JAG1 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

Q&As

How might knowledge of JAG1 protein be applied in the field of regenerative medicine?

Understanding the role of JAG1 in tissue regeneration and repair may lead to advances in regenerative medicine by promoting controlled cell differentiation.

Are there any clinical tests available for detecting JAG1 mutations in patients?

Yes, genetic testing can be performed to identify JAG1 mutations in individuals suspected of having Alagille syndrome or related conditions.

Are there any targeted therapies or treatments related to the JAG1 protein for Alagille syndrome?

Currently, there are no specific targeted therapies for JAG1-related conditions. Treatment typically focuses on managing symptoms and complications.

Are there any clinical trials currently investigating JAG1-related therapies or treatments?

Some clinical trials may be exploring therapies or treatments related to JAG1 in the context of specific medical conditions, but it's essential to check for the most up-to-date information.

Can JAG1 be a target for cancer therapy?

Yes, JAG1 is being investigated as a potential target for cancer therapy, as its role in the Notch pathway can influence cell proliferation and tumor growth.