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Jag1

  • Official Full Name

    jagged 1

  • Overview

    The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor Notch-1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
  • Synonyms

    Jagged1; JAG1; AGS; AHD; AWS; CD339; HJ1; JAGL1; jagged 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • C
  • 6×His
  • Fc
  • His
  • Myc
  • DDK
  • Flag
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|SUMO|Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAG1-380H Active Recombinant Human JAG1, Fc-tagged HEK293 Fc
Human JAG1-379H Active Recombinant Human JAG1 protein, Fc-tagged CHO Fc Ser32-Ser1046
Human JAG1-3226H Active Recombinant Human JAG1 protein, His-tagged HEK293 His Gln34-Ser1046
Human JAG1-3138H Active Recombinant Human JAG1, Fc tagged HEK293 Fc Met 1-Ser 1046
Human JAG1-566H Recombinant Human JAG1 Mammalian Cell His
Human JAG1-1821H Recombinant Human JAG1 protein, His-tagged E.coli His Gly33~Asp250 (Accession # P78504)
Human JAG1-2382HCL Recombinant Human JAG1 cell lysate Human Cell N/A
Human JAG1-2348H Recombinant Human JAG1 Protein, His-tagged E.coli N-His Gly33-Asp250
Human JAG1-792H Recombinant Human JAG1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human JAG1-344H Recombinant Human JAG1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human JAG1-338H Recombinant Human JAG1 Protein, His-tagged HEK293 His 1218
Human JAG1-1226H Recombinant Human JAG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human JAG1-5856H Recombinant Human JAG1 protein, hFc-Myc-tagged HEK293 hFc-Myc 185-334aa
Human JAG1-1115HFL Recombinant Full Length Human JAG1 Protein, C-Flag-tagged Mammalian cells Flag
Human JAG1-1226H-B Recombinant Human JAG1 Protein Pre-coupled Magnetic Beads HEK293
Human JAG1-4065H Recombinant Human JAG1 Protein (Met1-Ser1046), C-His tagged Mammalian cells C-His Met1-Ser1046
Human JAG1-2374H Recombinant Human JAG1 Protein (Gly33-Asp250), His tagged E.coli His Gly33-Asp250
Human JAG1-2375H Recombinant Human JAG1 Protein (Gln34-Ser1046), C-Fc tagged Mammalian cells C-Fc Gln34-Ser1046
Mouse Jag1-381M Active Recombinant Mouse Jag1, Fc-tagged HEK293 Fc
Mouse Jag1-1264M Recombinant Mouse Jag1 Protein, His-Sumo/MYC-tagged E.coli His/SUMO/Myc
Mouse Jag1-1822M Recombinant Mouse Jag1 protein, His-tagged E.coli His Ser826~Cys1084
Mouse Jag1-3625M Recombinant Mouse Jag1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Jag1-1795R Recombinant Rat Jagged 1 Mammalian cells N/A
Rat JAG1-3134R Recombinant Rat JAG1 Protein Mammalian Cell His
Rat Jag1-12R Active Recombinant Rat Jag1 Protein (Ser32-Asp1067), C-6×His-tagged NS0 C-6×His Ser32-Asp1067
Rat Jag1-1705R Recombinant Rat Jag1 Protein, His-tagged E.coli N-His Ser826-Cys1084
Rat Jag1-6386R-B Recombinant Rat Jag1 Protein Pre-coupled Magnetic Beads HEK293
Rat Jag1-6386R Recombinant Rat Jag1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey JAG1-1761R Recombinant Rhesus Monkey JAG1 Protein HEK293 N/A
Rhesus monkey JAG1-1763R Recombinant Rhesus Monkey JAG1 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey JAG1-1762R Recombinant Rhesus Monkey JAG1 Protein, hIgG1-tagged HEK293 hIgG1
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Jag1 Related Articles
  • Jag1 Related Research Area

Jag1 involved in several pathways and played different roles in them. We selected most pathways Jag1 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, which may be useful for your reference. Also, other proteins which involved in the same pathway with Jag1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated NOTCH1 Transmits Signal to the NucleusJAG1;ADAM10;JAG2;DTX2;MIB1;CNTN1;DLK1;DNER
Constitutive Signaling by NOTCH1 HD Domain MutantsJAG1;ADAM10;MIB1;JAG2
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsHDAC6;MIB1;HEY1;HEY2;JAG1;HDAC5;JAG2;ADAM10;CCNC
Constitutive Signaling by NOTCH1 PEST Domain MutantsCCNC;ADAM10;MIB1;JAG2;JAG1;CDK8;HDAC6;HEYL;HEY1
Constitutive Signaling by NOTCH1 t(7JAG2;JAG1
9)(NOTCH1:M1580_K2555) Translocation MutantJAG2;JAG1
Delta-Notch Signaling PathwayYY1;ASCL1A;ZFPM1;JAG1;RING1;WDR12;MAGEA1;NOV;CNTFR
DiseaseCCDC167;KPNA5;MMADHC;NUPL2;AP2A1;PSIP1;CTDP1;FDXR;KERA
Diseases of signal transductionCTBP2;TNKS;TRIM24;FKBP1A;DERL2;HEY2;MYO18A;HEY1;TNKS2

Jag1 has several biochemical functions, for example, Notch binding, calcium ion binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Jag1 itself. We selected most functions Jag1 had, and list some proteins which have the same functions with Jag1. You can find most of the proteins on our site.

Function Related Protein
Notch bindingNOTCH1;NOV;NOTCH4;GALNT11;JAG1;DLL4;AAK1;C8orf4;DLL1
calcium ion bindingSLC25A23;PCDHB11;CABP1;AKR1C1;ITSN2A;BGLAP;C1R;PCDHGC4;C2CD4A
growth factor activityINHA;MANF;BMP7A;NUDT6;REG1A;FGF6A;GFER;GDF10;BMP1
protein bindingCHN2;DNMT3L;MYO6;PRKD1;EHD3;STAP2;DPP3;GABPA;KRTAP23-1
structural molecule activityCLDN15;CLDN18;COPB2;COPE;INAB;SPRR2A;CLDN7A;LMNL3;CLDN19

Jag1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Jag1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Jag1.

CD46; NOTCH1; ADAM17; NOTCH3; mdtB; argS; CALR; CANX

Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
Lin, YY; Chen, WL; et al. Overexpression of Jagged-1 combined with blockade of CD40 pathway prolongs allograft survival. IMMUNOLOGY AND CELL BIOLOGY 93:213-217(2015).
  • Q&As
  • Reviews

Q&As (5)

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How might knowledge of JAG1 protein be applied in the field of regenerative medicine? 12/26/2020

Understanding the role of JAG1 in tissue regeneration and repair may lead to advances in regenerative medicine by promoting controlled cell differentiation.

Are there any clinical tests available for detecting JAG1 mutations in patients? 09/10/2019

Yes, genetic testing can be performed to identify JAG1 mutations in individuals suspected of having Alagille syndrome or related conditions.

Are there any targeted therapies or treatments related to the JAG1 protein for Alagille syndrome? 11/06/2017

Currently, there are no specific targeted therapies for JAG1-related conditions. Treatment typically focuses on managing symptoms and complications.

Are there any clinical trials currently investigating JAG1-related therapies or treatments? 09/05/2017

Some clinical trials may be exploring therapies or treatments related to JAG1 in the context of specific medical conditions, but it's essential to check for the most up-to-date information.

Can JAG1 be a target for cancer therapy? 05/09/2016

Yes, JAG1 is being investigated as a potential target for cancer therapy, as its role in the Notch pathway can influence cell proliferation and tumor growth.

Customer Reviews (3)

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Reviews
06/24/2021

    When used in Western blotting experiments, the JAG1 protein produces distinct protein bands, allowing for easy visualization and interpretation.

    08/29/2020

      Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.

      04/04/2016

        JAG1 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

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