Active Recombinant Human ST2 Protein

• Cat.No.: IL1RL1-1009H
• Product Overview: Recombinant Human ST2 also known as interleukin-1receptor-like 1 antigen is produced by mammalian expression system and the target gene encoding Lys19- Phe328 is expressed with a 6His tag at the C-terminus. Predicted molecular weight: 60 kDa.

Specification

• Description: ST2 is an interleukin-1 family receptor expressed in the heart. ST2 protein has two isoforms: a soluble (sST2) and membrane- bound form. Patients with heart failure and elevated ST2 protein levels in the blood are at risk for heart failure progression.
• Source: Human cells
• Species: Human
• Tag: His
• Form: Lyophilized
• Bio-activity: Anti-h ST2 10201: + Anti-h ST2 10202: + Anti-h ST2 10203: + Anti-h ST2 10204: + Anti-h ST2 10205: + Anti-h ST2 10206: + Anti-h ST2 10207: +
• Molecular Mass: 60kDa
• AA Sequence: KFSKQSWGLENEALIVRCPRQGKPS YTVDWYYSQTNKSIPTQERNRVFAS GQLLKFLPAAVADSG IYTCIVRSPTFNRTGYANVTIYKKQ SDCNVPDYLMYSTVSGSEKNSKIYC PTIDLYNWTAPLEWF KNCQALQGSRYRAHKSFLVIDNVMT EDAGDYTCKFIHNENGANYSVTATR SFTVKDEQGFSLFPV IGAPAQNEIKEVEIGKNANLTCSAC FGKGTQFLAAVLWQLNGTKITDFGE PRIQQEEGQNQSFSN GLACLDMVLRIADVKEEDLLLQYDC LALNLHGLRRHTVRLSRKNPSKECF VDHHHHHH
• Purity: >90% by SDS-PAGE
• Storage: -20centigrade
• Concentration: 0.5 mg/ml when reconstituted with 100 µl of deionized wate
• Storage Buffer: 20 mM Na-phosphate, pH 7.4, 150 mM NaCl
• Reconstitution: Reconstitute lyophilized protein with 100 µl of deionized water

Gene Information

• Gene Name: IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
• Official Symbol: IL1RL1
• Synonyms: IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623
• Gene ID: 9173
• mRNA Refseq: NM_003856
• Protein Refseq: NP_003847
• MIM: 601203
• UniProt ID: Q01638

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.